Miljøstøtte for Inst. for eksperimentell med. forskning
- Prosjektnummer
- 2004186
- Ansvarlig person
- Ole M. Sejersted
- Institusjon
- Oslo universitetssykehus HF - Ullevål sykehus
- Prosjektkategori
- Forskningsgruppe
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 1. Underpinning
Tamoxifen administration routes and dosage for inducible Cre-mediated gene disruption in mouse hearts.
Transgenic Res 2010 Aug;19(4):715-25. Epub 2009 nov 6
PMID: 19894134
Release of tissue-type plasminogen activator (t-PA) in the splanchnic circulation of the anaesthetised pig during high sympathetic tone.
Thromb Res 2010 Mar;125(3):e106-9. Epub 2009 nov 20
PMID: 19931890
Reference gene alternatives to Gapdh in rodent and human heart failure gene expression studies.
BMC Mol Biol 2010;11():22. Epub 2010 mar 23
PMID: 20331858
High-intensity exercise training in mice with cardiomyocyte-specific disruption of Serca2.
J Appl Physiol 2010 May;108(5):1311-20. Epub 2010 feb 18
PMID: 20167673
Cell treatment after acute myocardial infarction prevents early decline in circulating IGF-1.
Scand Cardiovasc J 2010 Oct;44(5):267-72.
PMID: 21080844
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice.
Am J Physiol Heart Circ Physiol 2010 Nov;299(5):H1671-8. Epub 2010 aug 27
PMID: 20802136
Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure.
Am J Physiol Regul Integr Comp Physiol 2010 Mar;298(3):R808-14. Epub 2009 des 23
PMID: 20032264
Cardiac structural and functional changes in competitive amateur cyclists.
Echocardiography 2010 Jan;27(1):11-6. Epub 2009 sep 18
PMID: 19765071
Herpes simplex virus-induced cardiomyopathy successfully treated with acyclovir.
Wien Klin Wochenschr 2010 Oct;122(19-20):592-5. Epub 2010 sep 28
PMID: 20865454
Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis.
Cell Calcium 2011 Apr;49(4):201-7. Epub 2010 okt 20
PMID: 20965565
Control of Ca2+ release by action potential configuration in normal and failing murine cardiomyocytes.
Biophys J 2010 Sep;99(5):1377-86.
PMID: 20816049
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout.
J Physiol 2010 Feb;588(Pt 3):465-78. Epub 2009 des 14
PMID: 20008467
There goes the neighborhood: pathological alterations in T-tubule morphology and consequences for cardiomyocyte Ca2+ handling.
J Biomed Biotechnol 2010;2010():503906. Epub 2010 apr 8
PMID: 20396394
Plasma IL-18 and IL-18BP are altered differently in reverse remodeling following aortic valve replacement.
Scand Cardiovasc J 2010 Apr;44(2):113-8.
PMID: 19961286
Revisited and revised: is RhoA always a villain in cardiac pathophysiology?
J Cardiovasc Transl Res 2010 Aug;3(4):330-43. Epub 2010 mai 27
PMID: 20559774
Training effects on skeletal muscle calcium handling in human chronic heart failure.
Med Sci Sports Exerc 2010 May;42(5):847-55.
PMID: 19996998
Presence of Borrelia burgdorferi in endomyocardial biopsies in patients with new-onset unexplained dilated cardiomyopathy.
Med Microbiol Immunol 2010 May;199(2):139-43. Epub 2010 jan 6
PMID: 20052487
Natriuretic peptides increase beta1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition.
Cardiovasc Res 2010 Mar;85(4):763-72. Epub 2009 nov 9
PMID: 19900965
Chromogranin B in heart failure: a putative cardiac biomarker expressed in the failing myocardium.
Circ Heart Fail 2010 Jul;3(4):503-11. Epub 2010 jun 2
PMID: 20519641
Preserved metabolic reserve capacity in skeletal muscle of post-infarction heart failure patients.
Scand J Med Sci Sports 2012 Apr;22(2):199-206. Epub 2010 sep 28
PMID: 20874858
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes.
Cardiovasc Res 2010 Apr;86(1):63-71. Epub 2009 des 17
PMID: 20019150
Functional coupling of alpha(2)-isoform Na(+)/K(+)-ATPase and Ca(2+) extrusion through the Na(+)/Ca(2+)-exchanger in cardiomyocytes.
Cell Calcium 2010 Jul;48(1):54-60. Epub 2010 jul 25
PMID: 20667414
Circulating cytokine levels in mice with heart failure are etiology dependent.
J Appl Physiol 2010 May;108(5):1357-64. Epub 2010 mar 11
PMID: 20224000
Multiple cytokine biomarkers in heart failure.
Expert Rev Mol Diagn 2010 Mar;10(2):147-57.
PMID: 20214534
Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling.
Circ Heart Fail 2009 Nov;2(6):624-32. Epub 2009 sep 22
PMID: 19919988
Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models.
Cell Calcium 2009 Sep;46(3):219-25. Epub 2009 aug 18
PMID: 19692123
Causes of fatigue in slow-twitch rat skeletal muscle during dynamic activity.
Am J Physiol Regul Integr Comp Physiol 2009 Sep;297(3):R900-10. Epub 2009 jul 22
PMID: 19625691
Cardiac troponin I degradation in serum of patients with hypertrophic obstructive cardiomyopathy undergoing percutaneous septal ablation.
Cardiology 2009;114(3):167-73. Epub 2009 jul 2
PMID: 19571537
Effect of piboserod, a 5-HT4 serotonin receptor antagonist, on left ventricular function in patients with symptomatic heart failure.
Eur J Heart Fail 2009 Aug;11(8):771-8. Epub 2009 jun 30
PMID: 19567409
Effects of bilirubin ditaurate overload on canalicular membrane function and ultrastructure of the pig liver.
Injury 2009 Aug;40(8):868-72. Epub 2009 apr 18
PMID: 19376516
Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats.
Am J Physiol Regul Integr Comp Physiol 2009 Jul;297(1):R26-33. Epub 2009 apr 1
PMID: 19339678
Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure.
Eur Heart J 2009 May;30(10):1229-36. Epub 2009 mar 26
PMID: 19329498
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.
J Mol Cell Cardiol 2009 Aug;47(2):180-7. Epub 2009 mar 26
PMID: 19328205
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice.
Am J Physiol Heart Circ Physiol 2009 Apr;296(4):H1069-79. Epub 2009 feb 6
PMID: 19201998
Elevated levels of activin A in clinical and experimental pulmonary hypertension.
J Appl Physiol 2009 Apr;106(4):1356-64. Epub 2009 feb 5
PMID: 19196915
ABCB4 sequence variations in young adults with cholesterol gallstone disease.
Liver Int 2009 May;29(5):743-7. Epub 2008 okt 24
PMID: 19018976
Gene expression profiles reflect sclerosing cholangitis activity in abcb4 (-/-) mice.
Scand J Gastroenterol 2009;44(2):211-8.
PMID: 18785065
Anterior myocardial infarction with acute percutaneous coronary intervention and intracoronary injection of autologous mononuclear bone marrow cells: safety, clinical outcome, and serial changes in left ventricular function during 12-months' follow-up.
J Am Coll Cardiol 2008 Feb;51(6):674-6.
PMID: 18261689
Slow contractions characterize failing rat hearts.
Basic Res Cardiol 2008 Jul;103(4):328-44. Epub 2008 mar 17
PMID: 18347833
Altered Na+/Ca2+-exchanger activity due to downregulation of Na+/K+-ATPase alpha2-isoform in heart failure.
Cardiovasc Res 2008 Apr;78(1):71-8. Epub 2008 jan 17
PMID: 18203708
Cardiomyocytes from postinfarction failing rat hearts have improved ischemia tolerance.
Am J Physiol Heart Circ Physiol 2009 Mar;296(3):H787-95. Epub 2009 jan 9
PMID: 19136604
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation.
Br J Pharmacol 2009 Feb;156(4):575-86. Epub 2009 jan 21
PMID: 19159405
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles.
Br J Pharmacol 2008 Dec;155(7):1005-14. Epub 2008 sep 1
PMID: 18846035
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A.
Cardiovasc Res 2008 Oct;80(1):47-54. Epub 2008 jul 3
PMID: 18599478
Alterations in circulating activin A, GDF-15, TGF-beta3 and MMP-2, -3, and -9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis.
Eur J Heart Fail 2008 Dec;10(12):1201-7. Epub 2008 nov 7
PMID: 18996047
Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure.
J Mol Cell Cardiol 2008 Aug;45(2):261-9. Epub 2008 mai 28
PMID: 18585734
Regulation of neuronal type genes in congestive heart failure rats.
Acta Physiol (Oxf) 2006 Jan;186(1):17-27.
PMID: 16497176
Cardiac fibrinolytic capacity is markedly increased after brief periods of local myocardial ischemia, but declines following successive periods in anesthetized pigs.
J Thromb Haemost 2005 Sep;3(9):1947-54.
PMID: 16102101
Cross-reinnervation changes the expression patterns of the monocarboxylate transporters 1 and 4: An experimental study in slow and fast rat skeletal muscle.
Neuroscience 2006;138(4):1105-13. Epub 2006 jan 30
PMID: 16446038
EC-coupling in normal and failing hearts.
Scand Cardiovasc J 2005 Apr;39(1-2):13-23.
PMID: 16097409
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes.
Am J Physiol Heart Circ Physiol 2007 Oct;293(4):H2367-76. Epub 2007 jul 27
PMID: 17660386
Effects of treatment with a 5-HT4 receptor antagonist in heart failure.
Br J Pharmacol 2007 Jan;150(2):143-52. Epub 2006 des 11
PMID: 17160012
Expression of mRNA encoding G protein-coupled receptors involved in congestive heart failure--a quantitative RT-PCR study and the question of normalisation.
Basic Res Cardiol 2007 May;102(3):198-208. Epub 2007 mar 19
PMID: 17370034
Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle.
J Mol Cell Cardiol 2007 Dec;43(6):767-79. Epub 2007 sep 5
PMID: 17936780
Artifactual contractions triggered by field stimulation of cardiomyocytes.
J Appl Physiol 2005 May;98(5):1712-9. Epub 2005 jan 7
PMID: 15640393
pH dependent uptake of porphyrin-type photosensitizers by solid tumor cells in vitro is not induced by modification of transmembrane potential.
Cancer Lett 2005 May;222(1):39-47.
PMID: 15837539
Comparison of nonviral transfection and adeno-associated viral transduction on cardiomyocytes.
Mol Biotechnol 2004 Sep;28(1):21-32.
PMID: 15456960
Frequency-dependent and proarrhythmogenic effects of FK-506 in rat ventricular cells.
Am J Physiol Heart Circ Physiol 2005 Feb;288(2):H778-86. Epub 2004 okt 7
PMID: 15471978
Increased syndecan expression following myocardial infarction indicates a role in cardiac remodeling.
Physiol Genomics 2004 Feb;16(3):301-8. Epub 2004 feb 13
PMID: 14625378
Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse.
J Appl Physiol 2005 Feb;98(2):680-9. Epub 2004 okt 8
PMID: 15475595
Leukaemia inhibitory factor alters expression of genes involved in rat cardiomyocyte energy metabolism.
Acta Physiol Scand 2004 Feb;180(2):133-42.
PMID: 14738472
Leukemia inhibitory factor reduces contractile function and induces alterations in energy metabolism in isolated cardiomyocytes.
J Mol Cell Cardiol 2004 Dec;37(6):1183-93.
PMID: 15572048
Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure.
Diabetologia 2006 Apr;49(4):724-31. Epub 2006 feb 18
PMID: 16489447
Activin A inhibits organization of sarcomeric proteins in cardiomyocytes induced by leukemia inhibitory factor.
J Mol Cell Cardiol 2006 Oct;41(4):689-97. Epub 2006 aug 22
PMID: 16926021
Pentobarbital versus medetomidine-ketamine-fentanyl anaesthesia: effects on haemodynamics and the incidence of ischaemia-induced ventricular fibrillation in swine.
Lab Anim 2004 Jan;38(1):70-8.
PMID: 14979991
How to discriminate between hibernating and stunned myocardium.
J Cardiovasc Surg (Torino) 2006 Jun;47(3):323-8.
PMID: 16760869
MRI of slow flow in artificial duct in swine.
Eur Radiol 2004 Sep;14(9):1692-7. Epub 2004 feb 7
PMID: 14767600
Reduced release of vasoconstrictors from the porcine heart after repeated periods of ischemia.
Scand Cardiovasc J 2005 Apr;39(1-2):60-6.
PMID: 16097416
Influence of endogenous neuropeptide Y (NPY) on the sympathetic-parasympathetic interaction in the canine heart.
J Cardiovasc Pharmacol 2005 Oct;46(4):474-80.
PMID: 16160600
Ventricular fibrillation induced by ischemia-reperfusion is not prevented by the NPY Y2 receptor antagonist BIIE0246.
J Cardiovasc Pharmacol Ther 2006 Sep;11(3):177-83.
PMID: 17056830
Reduced immune responses to an aseptic inflammation in mice with congestive heart failure.
Eur J Haematol 2005 Aug;75(2):156-63.
PMID: 16000132
[Nobel Prize for genetic modification]
Tidsskr Nor Laegeforen 2007 Nov;127(23):3054.
PMID: 18049491
[Research and research education are important]
Tidsskr Nor Laegeforen 2006 May;126(11):1495-6.
PMID: 16732347
Diagnostic approach to the patient with jaundice following trauma.
Scand J Surg 2004;93(3):176-83.
PMID: 15544071
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice.
Am J Physiol Heart Circ Physiol 2006 Aug;291(2):H507-16. Epub 2006 mar 31
PMID: 16582020
Contribution of the Na+/Ca2+ exchanger to rapid Ca2+ release in cardiomyocytes.
Biophys J 2006 Aug;91(3):779-92. Epub 2006 mai 5
PMID: 16679359
T-tubule disorganization and reduced synchrony of Ca2+ release in murine cardiomyocytes following myocardial infarction.
J Physiol 2006 Jul;574(Pt 2):519-33. Epub 2006 mai 18
PMID: 16709642
Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction.
N Engl J Med 2006 Sep;355(12):1199-209.
PMID: 16990383
Exercise capacity and quality of life after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: results from the Autologous Stem cell Transplantation in Acute Myocardial Infarction (ASTAMI) randomized controlled trial.
Am Heart J 2007 Oct;154(4):710.e1-8.
PMID: 17892996
Effects of congestive heart failure on Ca2+ handling in skeletal muscle during fatigue.
Circ Res 2006 Jun;98(12):1514-9. Epub 2006 mai 11
PMID: 16690878
Time course of degradation of cardiac troponin I in patients with acute ST-elevation myocardial infarction: the ASSENT-2 troponin substudy.
Circ Res 2006 Nov;99(10):1141-7. Epub 2006 okt 12
PMID: 17038641
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure.
J Mol Cell Cardiol 2007 Aug;43(2):177-86. Epub 2007 mai 17
PMID: 17574269
Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/ - ) mice harbouring chronic cholangitis.
Scand J Gastroenterol 2007 Oct;42(10):1245-55.
PMID: 17852852
Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart.
Circ Res 2005 Aug;97(3):268-76. Epub 2005 jul 7
PMID: 16002744
Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure.
Cardiovasc Res 2005 Mar;65(4):869-78.
PMID: 15721867
Carvedilol blockade of alpha1- and beta-adrenoceptor induced inotropic responses in rats with congestive heart failure.
Eur J Pharmacol 2005 May;516(1):51-9.
PMID: 15916756
Differential regulation of vacuolar H+ -ATPase and Na+/H+ exchanger 3 in rat cholangiocytes after bile duct ligation.
Histochem Cell Biol 2006 Apr;125(4):419-28. Epub 2005 nov 3
PMID: 16267653
Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration.
Glia 2004 May;46(3):225-51.
PMID: 15048847
Defective excitation-contraction coupling in hearts of rats with congestive heart failure.
Acta Physiol Scand 2005 May;184(1):45-58.
PMID: 15847643
Slow diffusion of K+ in the T tubules of rat cardiomyocytes.
J Appl Physiol 2006 Oct;101(4):1170-6. Epub 2006 jun 8
PMID: 16763106
The Na+/K+-ATPase alpha2-isoform regulates cardiac contractility in rat cardiomyocytes.
Cardiovasc Res 2007 Jul;75(1):109-17. Epub 2007 mar 24
PMID: 17442282
Muscle dysfunction during exercise of a single skeletal muscle in rats with congestive heart failure is not associated with reduced muscle blood supply.
Acta Physiol Scand 2004 Jun;181(2):173-81.
PMID: 15180789
Temperature-dependent skeletal muscle dysfunction in rats with congestive heart failure.
J Appl Physiol 2005 Oct;99(4):1500-7. Epub 2005 jun 2
PMID: 15932960
Enhanced matrix metalloproteinase activity in skeletal muscles of rats with congestive heart failure.
Am J Physiol Regul Integr Comp Physiol 2005 Aug;289(2):R389-R394. Epub 2005 mar 31
PMID: 15802562
Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats.
J Magn Reson Imaging 2005 Oct;22(4):492-500.
PMID: 16161073
Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure.
Circulation 2005 May;111(19):2461-8. Epub 2005 mai 9
PMID: 15883214
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice.
Am J Physiol Heart Circ Physiol 2005 Aug;289(2):H708-14. Epub 2005 apr 8
PMID: 15821032
Elevated levels of activin A in heart failure: potential role in myocardial remodeling.
Circulation 2004 Mar;109(11):1379-85. Epub 2004 mar 1
PMID: 14993131
Grunnbok i kirurgisk patofysiologi og intensivmedisin
2004. ISBN: 8292354034
Grunnbok i kirurgisk patofysiologi og intensivmedisin
2005. ISBN: 9788292354056
Grunnbok i kirurgisk patofysiologi og intensivmedisin
2006. ISBN: 9788292354063
Grunnbok i kirurgisk patofysiologi og intensivmedisin
2007. ISBN: 9788292354070
Stamcelletransplantasjon: Fremtidig håp ved behandling av myokardskade?
Hjerteforum 178, ss. 69-72. 2005.
Nyrefunksjon og elektrolyttbalanse.
In: Stokke O, Hagve T-A (eds.), Klinisk biokjemi og fysiologi. Gyldendal Norsk Forlag AS. 2006: 277-302. ISBN 9788205351769.
Hjertets patofysiologi.
In: Stokke O, Hagve T-A (eds.), Klinisk biokjemi og fysiologi. Gyldendal Norsk Forlag AS. 2006:217-239. ISBN 9788205351769.
Hjertets elektrofysiologi.
In: Stokke O, Hagve T-A (eds.), Klinisk biokjemi og fysiologi. Gyldendal Norsk Forlag AS. 2006: 240-270. ISBN: 9788205351769.
Mouse models of human cardiovascular disease.
In: Chien KR (ed.), Molecular Basis of Cardiovascular Disease. A Companion to Braunwald's Heart Disease. Elsevier. 2006: 72-106. ISBN 0721694284.
Pulmonary hypertension and cardiac dysfunction; the role of hypoxia and cytokines
- Disputert:
- desember 2010
- Hovedveileder:
- Christensen Geir og Ole Henning Skjønsberg
Fatigue mechanisms and skeletal muscle function in experimental and human heart failure
- Disputert:
- mars 2010
- Hovedveileder:
- Per Kristian Lunde
Causes of altered skeletal muscle function in the post-infarction heart failure condition
- Disputert:
- oktober 2010
- Hovedveileder:
- Ole M. Sejersted
Cellular mechanisms of heart failure progression
- Disputert:
- desember 2009
- Hovedveileder:
- William E Louch
ABCB4 dysfunction and biliary disease
- Disputert:
- juni 2009
- Hovedveileder:
- Morten G Ræder
Molecular mechanisms in heart failure. The role of Syndecan-4 in development of myocardial hypertrophy and heart failure
- Disputert:
- desember 2009
- Hovedveileder:
- Geir Christensen
Causes of altered contractility of the failing heart
- Disputert:
- januar 2009
- Hovedveileder:
- Ole M. Sejersted
Dysfunctional signalling in congestive heart failure
- Disputert:
- juni 2007
- Hovedveileder:
- Ole M. Sejersted
Restricted diffusion of ions regulates cardiac function
- Disputert:
- desember 2007
- Hovedveileder:
- Ole M. Sejersted
Cytokines and heart failure. New roles for leukemia inhibitory factor in cardiomyocyte energy metabolism
- Disputert:
- mai 2006
- Hovedveileder:
- Geir Christensen
Skeletal muscle abnormalities in congestive heart failure
- Disputert:
- mars 2005
- Hovedveileder:
- Ole M. Sejersted
Cytokines and cardiac dysfunction. Experimental studies in mice after myocardial infarction
- Disputert:
- juni 2005
- Hovedveileder:
- Geir Christensen
Features of bile formation and hepatocellular ultrastructure during hyperbilirubinemia
- Disputert:
- februar 2004
- Hovedveileder:
- Morten G. Ræder
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