The relative role of complement and LPS in sepsis/SIRS: a rational for combined treatment with complement- and CD14/TLRs inhibitors.
- Prosjektnummer
- 2008061
- Ansvarlig person
- Tom Eirik Mollnes
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Inflammatory and Immune System
- Forskningsaktivitet
- 5. Treatment Developement
Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood.
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CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs.
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Mol Immunol 46:2838. 2009.
Genetic complement deficiencies dissociate the roles of human complement in the inflammatory responses: Lessons from nature
Mol Immunol 45:4145-4146. 2008.
Cyanobacterial LPS antagonist (CyP) - A novel and efficient inhibitor of Escherichia coli LPS-induced cytokine response in the p
Mol Immunol 45:4166. 2008.
Complement and CD14: Roles in E. coli-induced inflammation in the pig
- Disputert:
- desember 2009
- Hovedveileder:
- Tom Eirik Mollnes
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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