Muscarinic receptors and heart failure
- Prosjektnummer
- 2008075
- Ansvarlig person
- Finn Olav Levy
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 1. Underpinning
Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle.
J Pharmacol Exp Ther 2014 Sep;350(3):681-90. Epub 2014 jul 14
PMID: 25022512
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium.
Naunyn Schmiedebergs Arch Pharmacol 2014 May;387(5):407-17. Epub 2014 jan 15
PMID: 24424715 - Inngår i doktorgradsavhandlingen
Non-classical regulation of ß1- and ß 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi.
Naunyn Schmiedebergs Arch Pharmacol 2014 Dec;387(12):1177-86. Epub 2014 sep 13
PMID: 25216690
Gi proteins regulate adenylyl cyclase activity independent of receptor activation.
PLoS One 2014;9(9):e106608. Epub 2014 sep 9
PMID: 25203113
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart.
Br J Pharmacol 2014 Dec;171(23):5169-81.
PMID: 24547784
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.
J Mol Cell Cardiol 2013 Mar;56():129-38. Epub 2012 des 7
PMID: 23220156
PDE3, but not PDE4, reduces ß1 - and ß2 -adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients.
Br J Pharmacol 2013 Jun;169(3):528-38.
PMID: 23489141
Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility.
Naunyn Schmiedebergs Arch Pharmacol 2013 Aug;386(8):665-70. Epub 2013 mai 7
PMID: 23649864
NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors.
J Pharmacol Exp Ther 2013 Oct;347(1):69-79. Epub 2013 jul 25
PMID: 23887096
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium.
Br J Pharmacol 2013 Sep;170(2):366-79.
PMID: 23808942 - Inngår i doktorgradsavhandlingen
Enhancement of ß1-AR signalling by CNP through cGMP-mediated PDE3 inhibition in both non-failing and failing hearts
Manuscript in preparation - vil inngå i avhandlingen
Involvement of PDE2 in CNP enhancement of cAMP-mediated inotropic responses differs between normal and failing hearts
Manuscript in preparation - vil inngå i avhandlingen
CNP through NPR-B potentiates ß1-andrenoceptor signaling in normal and failing hearts
Talk at NSFT Winter Meeting 2015, Beito
Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts
Poster and poster award talk at the 7th International Conference on cGMP 2015, Trier, Germany
Cardiac tissue hypothyroidism and receptor functions in heart failure
Konferanse: NSFT vintermøte
C-type natriuretic peptide signalling through NPR-B enhances the ß1-AR signalling both in non-failing and failing rat hearts
Konferanse: CHFR symposium
- Finn Olav Levy Prosjektleder
- Lise Roman Moltzau Medveileder
- Silja Meier Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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