RNA-interference-based genomic screening for regulators of radiation sensitivity
- Prosjektnummer
- 2008081
- Ansvarlig person
- Randi Gussgard Syljuåsen
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Nytt flerårig forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.
Mol Cell Biol 2012 Oct;32(20):4226-36. Epub 2012 aug 20
PMID: 22907750
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.
Nucleic Acids Res 2012 Jan;40(2):477-86. Epub 2011 sep 21
PMID: 21937510
A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance.
EMBO Rep 2011 Jul;12(7):705-12. Epub 2011 jul 1
PMID: 21637299
The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells.
Radiother Oncol 2011 Oct;101(1):24-7. Epub 2011 jun 30
PMID: 21722983
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.
J Cell Biol 2010 Mar;188(5):629-38. Epub 2010 mar 1
PMID: 20194642
High-throughput siRNA screens using gammaH2AX as marker uncover key regulators of genome integrity in mammalian cells.
Cell Cycle 2010 Jun;9(12). Epub 2010 jun 7
PMID: 20699633
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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