Breast Cancer Genomics; Molecular profiles, tumor development and aggressiveness in unselected cases from Akershus University Hospital
- Prosjektnummer
- 2008119
- Ansvarlig person
- Vessela N. Kristensen
- Institusjon
- Akershus universitetssykehus HF
- Prosjektkategori
- Nytt flerårig forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 7. Disease Management
Allele-specific disparity in breast cancer.
BMC Med Genomics 2011 Dec;4(1):85. Epub 2011 des 21
PMID: 22188678
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival.
Breast Cancer Res Treat 2012 Jun;133(3):865-80. Epub 2011 nov 3
PMID: 22048815
Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features.
BMC Med Genomics 2011;4():77. Epub 2011 nov 1
PMID: 22044755
Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas.
BMC Cancer 2011;11():332. Epub 2011 aug 3
PMID: 21812955
Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling.
Proc Natl Acad Sci U S A 2012 Feb;109(8):2802-7. Epub 2011 sep 9
PMID: 21908711
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer.
BMC Bioinformatics 2011;12():197. Epub 2011 mai 24
PMID: 21609452
Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer.
Mol Oncol 2011 Feb;5(1):61-76. Epub 2010 nov 25
PMID: 21212030
miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors.
PLoS One 2011;6(2):e16915. Epub 2011 feb 22
PMID: 21364938
Divide and conquer: the genetic basis of molecular subclassification of breast cancer.
EMBO Mol Med 2011 Apr;3(4):183-5. Epub 2011 mar 10
PMID: 21394915
Combining gene signatures improves prediction of breast cancer survival.
PLoS One 2011;6(3):e17845. Epub 2011 mar 10
PMID: 21423775
Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway.
Brain Behav Immun 2011 Oct;25(7):1376-83. Epub 2011 apr 7
PMID: 21496483
Expression of BMI-1 and Mel-18 in breast tissue--a diagnostic marker in patients with breast cancer.
BMC Cancer 2010;10():686. Epub 2010 des 16
PMID: 21162745
Allele-specific copy number analysis of tumors.
Proc Natl Acad Sci U S A 2010 Sep;107(39):16910-5. Epub 2010 sep 13
PMID: 20837533
Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density.
Breast Cancer Res 2010;12(4):R65. Epub 2010 aug 27
PMID: 20799965
Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations.
Eur J Clin Pharmacol 2010 Dec;66(12):1199-205. Epub 2010 jul 28
PMID: 20665013
The genetics and epigenetics of fatigue.
PM R 2010 May;2(5):456-65.
PMID: 20656628
The epigenetics of breast cancer.
Mol Oncol 2010 Jun;4(3):242-54. Epub 2010 apr 29
PMID: 20627830
On the molecular biology of breast cancer.
Mol Oncol 2010 Jun;4(3):171-3. Epub 2010 apr 24
PMID: 20483673
NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations.
Mol Cancer 2010;9():113. Epub 2010 mai 19
PMID: 20482849
Mutations for the people.
EMBO Mol Med 2010 May;2(5):143-5.
PMID: 20461736
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.
Mol Cancer 2010;9():68. Epub 2010 mar 25
PMID: 20338046
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density.
BMC Med Genomics 2010;3():9. Epub 2010 mar 19
PMID: 20302654
SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance.
Pharmacogenomics J 2010 Dec;10(6):513-23. Epub 2010 feb 16
PMID: 20157331
Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression.
Mol Oncol 2010 Apr;4(2):98-118. Epub 2009 des 11
PMID: 20060370
Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer.
Breast Cancer Res 2010;12(1):R3. Epub 2010 jan 7
PMID: 20056007
Functional glutathione S-transferase genotypes among testicular germ cell tumor survivors: associations with primary and post-chemotherapy tumor histology.
Pharmacogenet Genomics 2009 Oct;19(10):751-9.
PMID: 19741569
Integrated study of copy number states and genotype calls using high-density SNP arrays.
Nucleic Acids Res 2009 Sep;37(16):5365-77. Epub 2009 jul 6
PMID: 19581427
A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide.
Clin Cancer Res 2009 Jun;15(12):4165-73. Epub 2009 jun 9
PMID: 19509150
Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines.
Oncogene 2009 Nov;28(44):3926-36. Epub 2009 aug 17
PMID: 19684618
GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas.
Cancer Res 2008 Jul;68(14):5562-71.
PMID: 18632608
Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival.
Int J Cancer 2008 Aug;123(3):577-85.
PMID: 18498133
Expression profiles of pre- and postoperative breast cancer tumours reveal genes that may be deregulated as result of surgical t
Breast cancer research and treatment, under review
Gene Expression Profile Analysis Comparing T1 and T2 Breast Cancer Reveals Different Activation Pathways
Breast Cancer Res and Treatment, under review
OncomiRs like let 7 and miR 21 are also deregulated in benign breast tumors
Neoplasia, under review
Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes
BMC Genomics, revised
Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway
British Journal of Cancer, under revision
A women’s genetic makeup is important for risk, type, and fate of breast cancer
Swiss Bridge Magazine
MSc, PhD
- Disputert:
- juni 2010
- Hovedveileder:
- Vessela Kristensen
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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