Role of AlkB homologs 1 and 7 (ABH1 and 7) in epigenetic reprogramming.
- Prosjektnummer
- 2008136
- Ansvarlig person
- Arne Klungland
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Nytt flerårig forskningsprosjekt
- Helsekategori
- Generic Health Relevance
- Forskningsaktivitet
- 1. Underpinning
Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes.
Nucleic Acids Res 2012 Nov;40(21):10950-63. Epub 2012 sep 10
PMID: 22965116
DNA repair is indispensable for survival after acute inflammation.
J Clin Invest 2012 Jul;122(7):2680-9. Epub 2012 jun 11
PMID: 22684101
Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads.
Nat Protoc 2012 Feb;7(2):340-50. Epub 2012 jan 26
PMID: 22281869
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Res 2011 Apr;39(8):e55. Epub 2011 feb 7
PMID: 21300643
The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression.
Biochem Biophys Res Commun 2011 Jul;411(1):40-3. Epub 2011 jun 15
PMID: 21703242
Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects.
PLoS One 2010;5(11):e13827. Epub 2010 nov 3
PMID: 21072209
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.
Mol Cell Biol 2010 Apr;30(7):1814-27. Epub 2010 feb 1
PMID: 20123966
Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria.
Nucleic Acids Res 2009 Nov;37(21):7124-36.
PMID: 19786499
AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.
Cancer Res 2008 Jun;68(11):4142-9.
PMID: 18519673
Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.
Cancer Res 2008 Jun;68(12):4571-9.
PMID: 18559501
8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells.
Proc Natl Acad Sci U S A 2008 Dec;105(48):18877-82. Epub 2008 nov 19
PMID: 19020090
Base excision repair: the long and short of it.
Cell Mol Life Sci 2009 Jan. Epub 2009 jan 21
PMID: 19153658
Role of the mammalian A1kB homologs 1 and 3 in RNA repair and epigenetic regulation of stem cell differentiation and development
- Disputert:
- mars 2012
- Hovedveileder:
- Arne Klungland
Genetic and epigenetic regulation in spermatogenesis in mice; lessons from Alkbh1 and Tzfp mutants
- Disputert:
- november 2012
- Hovedveileder:
- Arne Klungland
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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