The AlkB family of hydroxylases; roles in embryonic stem cell identity and epigenetic reprogramming of the germ line.
- Prosjektnummer
- 2010012
- Ansvarlig person
- Arne klungland
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Disputed aetiology and other
- Forskningsaktivitet
- 1. Underpinning
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Res 2012 Aug;40(14):6620-31. Epub 2012 apr 24
PMID: 22532610 - Inngår i doktorgradsavhandlingen
ALKBH1 is a histone H2A dioxygenase involved in neural differentiation.
Stem Cells 2012 Dec;30(12):2672-82.
PMID: 22961808 - Inngår i doktorgradsavhandlingen
Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads.
Nat Protoc 2012 Feb;7(2):340-50. Epub 2012 jan 26
PMID: 22281869
The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression.
Biochem Biophys Res Commun 2011 Jul;411(1):40-3. Epub 2011 jun 15
PMID: 21703242 - Inngår i doktorgradsavhandlingen
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Res 2011 Apr;39(8):e55. Epub 2011 feb 7
PMID: 21300643
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nat Commun 2011;2():172. Epub 2011 feb 1
PMID: 21285950 - Inngår i doktorgradsavhandlingen
Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects.
PLoS One 2010;5(11):e13827. Epub 2010 nov 3
PMID: 21072209 - Inngår i doktorgradsavhandlingen
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.
Mol Cell Biol 2010 Apr;30(7):1814-27. Epub 2010 feb 1
PMID: 20123966 - Inngår i doktorgradsavhandlingen
Continuous and periodic expansion of CAG repeats in Huntington's disease R6/1 mice.
PLoS Genet 2010;6(12):e1001242. Epub 2010 des 9
PMID: 21170307
Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos.
PLoS One 2010;5(2):e9150. Epub 2010 feb 10
PMID: 20161773 - Inngår i doktorgradsavhandlingen
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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