New insights into the molecular basis of colorectal cancer
- Prosjektnummer
- 2010017
- Ansvarlig person
- Edward Leithe
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Forskerstilling
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
Cell Signal 2013 Jan;25(1):12-8. Epub 2012 sep 5
PMID: 22974840
Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43.
J Cell Sci 2012 Sep;125(Pt 17):3966-76. Epub 2012 mai 23
PMID: 22623726
The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation.
J Biol Chem 2012 May;287(19):15851-61. Epub 2012 mar 12
PMID: 22411987
Endocytosis and post-endocytic sorting of connexins.
Biochim Biophys Acta 2012 Aug;1818(8):1870-9. Epub 2011 okt 4
PMID: 21996040
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome.
Int J Cancer 2012 Aug;131(3):570-81. Epub 2011 okt 20
PMID: 21866551
Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil.
Toxicol Appl Pharmacol 2010 Aug;247(1):10-7. Epub 2010 mai 25
PMID: 20510257
Regulation of gap junction intercellular communication by the ubiquitin system.
Cell Signal 2010 Sep;22(9):1267-73. Epub 2010 mar 4
PMID: 20206687
- Edward Leithe Prosjektleder
- Edgar Rivedal Forskningsgruppeleder
- Ane Hansen Kjenseth Doktorgradsstipendiat
- Solveig Sirnes Doktorgradsstipendiat
- Tone Aase Fykerud Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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