B7-H3 a novel prognostic marker and therapeutic target
- Prosjektnummer
- 2010030
- Ansvarlig person
- Øystein Fodstad
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c.
Br J Cancer 2014 Apr 15;110(8):2072-80. Epub 2014 feb 27
PMID: 24577056 - Inngår i doktorgradsavhandlingen
B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome.
BMC Cancer 2014;14():602. Epub 2014 aug 20
PMID: 25139714
B7-H3 expression in colorectal cancer: nuclear localization strongly predicts poor outcome in colon cancer.
Int J Cancer 2012 Dec;131(11):2528-36. Epub 2012 apr 24
PMID: 22473715
Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism.
Nat Commun 2012;3():1271.
PMID: 23232401
B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-associated genes.
Int J Cancer 2012 May;130(10):2282-90. Epub 2011 aug 8
PMID: 21671471 - Inngår i doktorgradsavhandlingen
B7-H3 and its relevance in cancer; immunological and non-immunological perspectives.
Front Biosci (Elite Ed) 2011;3():989-93. Epub 2011 jun 1
PMID: 21622107
B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation.
Mol Cancer Ther 2011 Jun;10(6):960-71. Epub 2011 apr 25
PMID: 21518725 - Inngår i doktorgradsavhandlingen
B7-H3 induces paclitaxel resistance by activatingJak2/Stat3-mediated prosurvival pathways in human breast cancer
Submitted
The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion
Curr Cancer Drug Targets 2008 Aug;8(5):404-13.
The role of the B7-H3 protein in cancer metastasis and resistance to chemotherapy
- Disputert:
- september 2011
- Hovedveileder:
- Øystein Fodstad
- Caroline Elisabeth Nunes-Xavier Postdoktorstipendiat
- Christina Tekle Doktorgradsstipendiat
- Marit Kveine Nygren Postdoktorstipendiat
- Vibeke Anett Ingebrigtsen Doktorgradsstipendiat
- Øystein Fodstad Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport