small drug antagonists for canonical Wnt signalling
- Prosjektnummer
- 2010031
- Ansvarlig person
- Stefan Krauss
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.
Cancer Res 2012 Jun;72(11):2822-32. Epub 2012 mar 22
PMID: 22440753
Mouse Tcf3 represses canonical Wnt signaling by either competing for ß-catenin binding or through occupation of DNA-binding sites.
Mol Cell Biochem 2012 Jun;365(1-2):53-63. Epub 2012 jan 22
PMID: 22270545
In vitro differentiation of mouse embryonic stem cells into neurons of the dorsal forebrain.
Cell Mol Neurobiol 2011 Jul;31(5):715-27. Epub 2011 mar 20
PMID: 21424551
A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model.
PLoS One 2011;6(6):e19904. Epub 2011 jun 15
PMID: 21698280
Insulin receptor substrate 2 is a negative regulator of memory formation.
Learn Mem 2011 Jun;18(6):375-83. Epub 2011 mai 19
PMID: 21597043
Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.
Cancer Res 2011 Jan;71(1):197-205.
PMID: 21199802
Dachshund homologues play a conserved role in islet cell development.
Dev Biol 2010 Dec;348(2):143-52. Epub 2010 sep 30
PMID: 20869363
Hedgehog antagonists cyclopamine and dihydroveratramine can be mistaken for each other in Veratrum album.
J Pharm Biomed Anal 2010 Nov;53(3):497-502.
PMID: 20646889
Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction.
BMC Mol Biol 2010;11():35. Epub 2010 mai 10
PMID: 20459736
Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified.
J Pharm Biomed Anal 2010 Sep;52(5):707-13. Epub 2010 feb 23
PMID: 20236786
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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