Ways to attenuate ErbB2-induced oncogenesis
- Prosjektnummer
- 2010040
- Ansvarlig person
- Espen Stang
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3.
Carcinogenesis 2013 Sep;34(9):2031-8. Epub 2013 mai 22
PMID: 23698633
Preubiquitinated chimeric ErbB2 is constitutively endocytosed and subsequently degraded in lysosomes.
Exp Cell Res 2013 Feb 1;319(3):32-45. Epub 2012 nov 2
PMID: 23127513 - Inngår i doktorgradsavhandlingen
Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis.
Exp Cell Res 2012 Dec;318(20):2578-91. Epub 2012 sep 11
PMID: 22975728 - Inngår i doktorgradsavhandlingen
Differential roles of Grb2 and AP-2 in p38 MAPK- and EGF-induced EGFR internalization.
Traffic 2011 Dec. Epub 2011 des 22
PMID: 22192528
CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor.
Exp Cell Res 2011 Aug;317(13):1804-16. Epub 2011 mai 20
PMID: 21635887
A chimeric pre-ubiquitinated EGF receptor is constitutively endocytosed in a clathrin-dependent, but kinase-independent manner.
Traffic 2011 Apr;12(4):507-20. Epub 2011 feb 8
PMID: 21226813
Nimotuzumab and cetuximab block ligand-independent EGF receptor signaling efficiently at different concentrations.
J Immunother 2011 Sep;34(7):550-5.
PMID: 21760527 - Inngår i doktorgradsavhandlingen
Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Tras
Pharamaceuticals, 5(7), 674-689
Effects of therapeutic antibodies and ubiquitination on dimerization and down-regulation of EGF receptor and ErbB2
- Disputert:
- januar 2013
- Hovedveileder:
- Inger Helene Madshus
Molecular Mechansims Controlling Endocytic Downregulation of EGFR and ErbB3
- Disputert:
- mars 2013
- Hovedveileder:
- Inger Helene Madshus
Mechanisms underlying the downregulation of receptor tyrosin kinases EGFR and ErbB2
- Disputert:
- november 2012
- Hovedveileder:
- Inger Helene Madshus
- Ute Krengel Prosjektdeltaker
- Monika Szymanska Prosjektdeltaker
- Inger Helene Madshus Prosjektleder
- Juliana Bentes Hughes Prosjektdeltaker
- Tram Thu Vuong Prosjektdeltaker
- Vibeke Bertelsen Prosjektdeltaker
- Malgorzata Magdalena Sak Prosjektdeltaker
- Christian Berger Doktorgradsstipendiat
- Espen Stang Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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