Injury of newborn infants. Basic mechanisms related to hyperoxia
- Prosjektnummer
- 2010052
- Ansvarlig person
- Ola Didrik Saugstad
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Reproductive Health and Childbirth
- Forskningsaktivitet
- 5. Treatment Developement
Transcriptome profiling of the newborn mouse brain after hypoxia-reoxygenation: hyperoxic reoxygenation induces inflammatory and energy failure responsive genes.
Pediatr Res 2014 Apr;75(4):517-26. Epub 2013 des 27
PMID: 24375083 - Inngår i doktorgradsavhandlingen
Transcriptome profiling of the newborn mouse lung after hypoxia and reoxygenation: hyperoxic reoxygenation affects mTOR signaling pathway, DNA repair, and JNK-pathway regulation.
Pediatr Res 2013 Nov;74(5):536-44. Epub 2013 sep 2
PMID: 23999071 - Inngår i doktorgradsavhandlingen
Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress.
Biochim Biophys Acta 2013 May;1833(5):1157-64. Epub 2013 jan 7
PMID: 23305905
Gene expression profiling in preterm infants: new aspects of bronchopulmonary dysplasia development.
PLoS One 2013;8(10):e78585. Epub 2013 okt 23
PMID: 24194948 - Inngår i doktorgradsavhandlingen
Impact of antenatal glucocorticosteroids on whole-genome expression in preterm babies.
Acta Paediatr 2013 Apr;102(4):349-55. Epub 2013 feb 11
PMID: 23347050
New insight into the pathogenesis of retinopathy of prematurity: assessment of whole-genome expression.
Pediatr Res 2013 Apr;73(4 Pt 1):476-83. Epub 2012 des 26
PMID: 23269122 - Inngår i doktorgradsavhandlingen
Hyperoxic resuscitation after hypoxia-ischemia induces cerebral inflammation that is attenuated by tempol in a reporter mouse model with very young mice.
J Perinat Med 2013 May;41(3):251-7.
PMID: 23241583 - Inngår i doktorgradsavhandlingen
Brain inflammation induced by severe asphyxia in newborn pigs and the impact of alternative resuscitation strategies on the newborn central nervous system.
Pediatr Res 2013 Feb;73(2):163-70. Epub 2012 nov 20
PMID: 23168577
Lung Injury in Asphyxiated Newborn Pigs Resuscitated from Cardiac Arrest - The Impact of Supplementary Oxygen, Longer Ventilation Intervals and Chest Compressions at Different Compression-to-Ventilation Ratios.
Open Respir Med J 2012;6():89-96. Epub 2012 sep 20
PMID: 23115599
Oxygenation of the newborn: a molecular approach.
Neonatology 2012;101(4):315-25. Epub 2012 jun 1
PMID: 22940621
Antioxidant protects against increases in low molecular weight hyaluronan and inflammation in asphyxiated newborn pigs resuscitated with 100% oxygen.
PLoS One 2012;7(6):e38839. Epub 2012 jun 11
PMID: 22701723
Nicotine does not influence NF-?B activity in neonatal mice reoxygenated with room-air or 100% oxygen.
J Matern Fetal Neonatal Med 2012 Oct;25(10):2102-5. Epub 2012 apr 20
PMID: 22489644
The impact of hyaluronan on monocyte Toll-like receptor expression in term infant cord blood.
Acta Paediatr 2012 Jul;101(7):706-13. Epub 2012 apr 7
PMID: 22372604
Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigs.
Eur J Nucl Med Mol Imaging 2012 May;39(5):792-9.
PMID: 22297457 - Inngår i doktorgradsavhandlingen
Resuscitation with 100% oxygen increases injury and counteracts the neuroprotective effect of therapeutic hypothermia in the neonatal rat.
Pediatr Res 2012 Mar;71(3):247-52. Epub 2012 jan 11
PMID: 22337259 - Inngår i doktorgradsavhandlingen
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia.
Proc Natl Acad Sci U S A 2011 Nov;108(46):18802-7. Epub 2011 nov 7
PMID: 22065741 - Inngår i doktorgradsavhandlingen
Hypoxia-reoxygenation affects whole-genome expression in the newborn eye.
nvest Ophthalmol Vis Sci. 2014 Mar 10;55(3):1393-401
Transcriptome profiling of the newborn mouse brain after hypoxia-reoxygenation
Pediatr Res. 2014 Apr;75(4):517-26
Gene expression profiling in preterm infants: new aspects of bronchopulmonary dysplasia development.
LoS One. 2013 Oct 23;8(10):e78585
Basic Newborn Resuscitation
2012, Geneva
Hypoxia and Reoxygenation Induces Alterations in Gene Expression in Eye Tissue of the Newborn Mouse
abstract # 754196, Pediatric Academic societies, Denver 2011
Whole Genome Expression in Newborn Mouse Brain Tissue after Hypoxia and Reoxygenation
European Society for Pediatric Research, Newcastle, 2011
Hypoxia and reoxygenation of newborn mice activate p53
European Society of Paediatric Research, Hamburg October 2009
Global gene expression in newborn mouse lung tissue after hypoxia and reoxygenation - A microarray study
25th International Workshop on Surfactant Replacement, Moscow June 2010
Hypoxia and reoxygenation induces alterations in whole genome expression in lung tissue of the newbon mice
European Academy of Paediatric Societies, Copenhagen October 2010
Short- and long term effects of supplemental oxygen on transcriptome profiles of the newborn
- Disputert:
- januar 2014
- Hovedveileder:
- Ola Didrik Saugstad
Hyalorunan in the neonatal period
- Disputert:
- januar 2014
- Hovedveileder:
- Ola Didrik Saugstad og Britt Nakstad
cand med, PhD
- Disputert:
- desember 2012
- Hovedveileder:
- Ola Didrik Saugstad
cand med, PhD
- Disputert:
- desember 2012
- Hovedveileder:
- Ola Didrik Saugstad
cand med, PhD
- Disputert:
- desember 2012
- Hovedveileder:
- Berit Munkeby
cand med PhD
- Disputert:
- oktober 2012
- Hovedveileder:
- Babill Stray-Pedersen og Ola Didrik Saugstad
- Ola Didrik Saugstad Prosjektleder
- Helene Dale Østerholt Doktorgradsstipendiat
- Torkil Benterud Doktorgradsstipendiat
- Embjørg Julianne Wollen Doktorgradsstipendiat
- Torkild Benterud Doktorgradsstipendiat
- Gaute Døhlen Doktorgradsstipendiat
- Yngve Sejersted Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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