Mechanisms of CCN2 in Cardioprotection and Myocardial Repair
- Prosjektnummer
- 2011006
- Ansvarlig person
- Håvard Attramadal
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 1. Underpinning
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Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure.
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Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice.
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Connective tissue growth factor induces tube formation and IL-8 production in first trimester human placental trophoblast cells.
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The matricellular "cysteine-rich protein 61" is released from activated platelets and increased in the circulation during experimentally induced sepsis.
Shock 2014 Mar;41(3):233-40.
PMID: 24430538
CCN2 exerts direct cytoprotective actions in adult cardiac myocytes by activation of the PI3-kinase/Akt/GSK-3ß signaling pathway.
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PMID: 23208610
CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload.
Int J Cardiol 2013 Oct 3;168(3):2049-56. Epub 2013 feb 26
PMID: 23452880
Myocardial Connective Tissue Growth Factor (CCN2/CTGF) Attenuates Left Ventricular Remodeling after Myocardial Infarction.
PLoS One 2012;7(12):e52120. Epub 2012 des 20
PMID: 23284892
Protecting the heart through delivering DNA encoding for heme oxygenase-1 into skeletal muscle.
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PMID: 22917518
The matri-cellular proteins 'cysteine-rich, angiogenic-inducer, 61' and 'connective tissue growth factor' are regulated in experimentally-induced sepsis with multiple organ dysfunction.
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PMID: 22334618
Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury.
Am J Physiol Heart Circ Physiol 2011 Apr;300(4):H1291-302. Epub 2010 des 24
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Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload.
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PMID: 21533157
Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo.
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Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload.
Eur Heart J 2011 Jan;32(2):236-45. Epub 2010 jun 5
PMID: 20525982
The Matricellular Protein CCN2/CTGF Alters Remodeling and Fibrotic Response Following Myocardial Infarction in Mice
Circulation. 2012;126:A14287 (Abstract, AHA Scientific Sessions 2012)
Investigations on Signaling Pathways and Functions of CCN2 in The Heart.
- Disputert:
- februar 2015
- Hovedveileder:
- Håvard Attramadal
Cardioprotective Mechanisms in Ischemia-Reperfusion Injury and Heart Failure
- Disputert:
- mai 2013
- Hovedveileder:
- Håvard Attramadal
- Vladimir Nikolaev Martinov Forsker (annen finansiering)
- Liv Kvistad Klemetsaune Doktorgradsstipendiat
- Ingvild Tronstad Moe Doktorgradsstipendiat
- Ole Jørgen Kaasbøll Doktorgradsstipendiat
- Jørgen A. Gravning Forsker (annen finansiering)
- Geir Florholmen Postdoktorstipendiat
- Muhammad Shakil Ahmed Forsker (annen finansiering)
- Håvard Attramadal Prosjektleder
- Else Marie Hagelin Prosjektdeltaker
- Else Marie Valbjørn Hagelin Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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