Genomic medicine of colorectal cancer
- Prosjektnummer
- 2011024
- Ansvarlig person
- Ragnhild A. Lothe
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Helse Sør-Øst forskningsgruppe
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis
Portrait of the PI3K/AKT pathway in colorectal cancer.
Biochim Biophys Acta 2015 Jan;1855(1):104-21. Epub 2014 nov 22
PMID: 25450577
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.
Clin Cancer Res 2015 Aug 15;21(16):3759-70. Epub 2015 apr 24
PMID: 25910952
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes.
Oncogene 2015 Aug 24. Epub 2015 aug 24
PMID: 26300000
Novel RNA variants in colorectal cancers.
Oncotarget 2015 Nov 3;6(34):36587-602.
PMID: 26474385
MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer.
Oncotarget 2015 Nov 25. Epub 2015 nov 25
PMID: 26623728
The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer.
Epigenetics 2014 Mar;9(3):346-50. Epub 2014 jan 2
PMID: 24384857
A novel transcript, VNN1-AB, as a biomarker for colorectal cancer.
Int J Cancer 2014 Nov 1;135(9):2077-84. Epub 2014 mar 29
PMID: 24687856
Connexins in colorectal cancer pathogenesis.
Int J Cancer 2014 Apr 18. Epub 2014 apr 18
PMID: 24752574
Prognostic Significance of ß-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series.
Front Oncol 2014;4():118. Epub 2014 mai 21
PMID: 24904831
Transcriptome instability as a molecular pan-cancer characteristic of carcinomas.
BMC Genomics 2014;15():672. Epub 2014 aug 10
PMID: 25109687
High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants.
PLoS One 2014;9(3):e91264. Epub 2014 mar 7
PMID: 24608966
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
Cell Signal 2013 Jan;25(1):12-8. Epub 2012 sep 5
PMID: 22974840
Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series.
Ann Oncol 2013 May;24(5):1274-82. Epub 2012 des 12
PMID: 23235802
Epigenetic and genetic features of 24 colon cancer cell lines.
Oncogenesis 2013;2():e71. Epub 2013 sep 16
PMID: 24042735
Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing.
Transl Oncol 2013;6(5):546-53. Epub 2013 okt 1
PMID: 24151535
Anticipating the clinical use of prognostic gene expression-based tests for colon cancer stage II and III: is Godot finally arriving?
Clin Cancer Res 2013 Dec 15;19(24):6669-77. Epub 2013 okt 28
PMID: 24166914
ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis.
Gut 2012 Nov;61(11):1560-7. Epub 2012 jan 2
PMID: 22213796
Vimentin in upper gastrointestinal pathologies--letter.
Cancer Epidemiol Biomarkers Prev 2012 Oct;21(10):1889; author reply 1890. Epub 2012 aug 28
PMID: 22929079
MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer.
Neoplasia 2012 Sep;14(9):868-79.
PMID: 23019418
A tissue-based comparative effectiveness analysis of biomarkers for early detection of colorectal tumors.
Clin Transl Gastroenterol 2012;3():e27. Epub 2012 des 6
PMID: 23324654
ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients.
Clin Cancer Res 2012 Nov;18(21):6001-10. Epub 2012 sep 18
PMID: 22991413
The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer.
Int J Cancer 2012 Sep;131(6):1479-85. Epub 2012 jan 11
PMID: 22173985
Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome.
PLoS One 2011;6(9):e24419. Epub 2011 sep 1
PMID: 21909432
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome.
Int J Cancer 2012 Aug;131(3):570-81. Epub 2011 okt 20
PMID: 21866551
CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer.
Genes Immun 2011 Dec;12(8):653-62. Epub 2011 jun 30
PMID: 21716316
Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival.
Genome Med 2011;3(5):32. Epub 2011 mai 27
PMID: 21619627
Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors.
J Surg Oncol 2011 Dec;104(7):792-7. Epub 2011 mai 5
PMID: 21547915
SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis.
Oncogene 2011 Sep;30(37):3967-78. Epub 2011 apr 18
PMID: 21499309
Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas.
Mol Cancer 2011;10():85. Epub 2011 jul 21
PMID: 21777459
Identification of novel fusion genes and transcript variants in cancer
- Disputert:
- november 2015
- Hovedveileder:
- Rolf Inge Skotheim
Biomarkers with functional and clinical impact on colorectal cancer
- Disputert:
- april 2014
- Hovedveileder:
- Ragnhild A Lothe
Genetic and clinical prognostic markers for colorectal cancer
- Disputert:
- mai 2014
- Hovedveileder:
- Arild Nesbakken
Genetics of colorectal cancer: new insights to early onset and to prognostication of disease
- Disputert:
- mars 2012
- Hovedveileder:
- Ragnhild A. Lothe
The transcriptome and prognosis in stgeII and III colorectal cancer
- Disputert:
- mars 2012
- Hovedveileder:
- Rolf I Skotheim
Post doc
- Disputert:
- november 2011
- Hovedveileder:
- Ragnhild A. Lothe
- Anita Sveen Postdoktorstipendiat
- Rolf Inge Skotheim Forskningsgruppeleder
- Ragnhild A Lothe Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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