The ‘Gutfeeling Group’: Coeliac Disease Research between Bench and Bedside.
- Prosjektnummer
- 2011050
- Ansvarlig person
- Ludvig M. Sollid
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Helse Sør-Øst Forskningsgruppe
- Helsekategori
- Inflammatory and Immune System
- Forskningsaktivitet
- 1. Underpinning
T Cells in Celiac Disease.
J Immunol 2017 Apr 15;198(8):3005-3014.
PMID: 28373482
Similar Responses of Intestinal T Cells From Untreated Children and Adults With Celiac Disease to Deamidated Gluten Epitopes.
Gastroenterology 2017 Sep;153(3):787-798.e4. Epub 2017 mai 20
PMID: 28535873
The roles of MHC class II genes and post-translational modification in celiac disease.
Immunogenetics 2017 08;69(8-9):605-616. Epub 2017 jul 10
PMID: 28695286
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions.
JCI Insight 2017 Sep 07;2(17). Epub 2017 sep 7
PMID: 28878121
HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge.
Gut 2018 09;67(9):1606-1613. Epub 2017 aug 4
PMID: 28779027
HLA-DQ-Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption.
Gastroenterology 2018 03;154(4):886-896.e6. Epub 2017 nov 14
PMID: 29146521
Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease.
J Immunol 2016 Mar 15;196(6):2819-26. Epub 2016 feb 19
PMID: 26895834
TCR sequencing of single cells reactive to DQ2.5-glia-a2 and DQ2.5-glia-?2 reveals clonal expansion and epitope-specific V-gene usage.
Mucosal Immunol 2016 May;9(3):587-96. Epub 2016 feb 3
PMID: 26838051
Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes.
Sci Rep 2016 May 05;6():25565. Epub 2016 mai 5
PMID: 27146306
The human intestinal B-cell response.
Mucosal Immunol 2016 Sep;9(5):1113-24. Epub 2016 jul 27
PMID: 27461177
Coeliac disease - from genetic and immunological studies to clinical applications.
Scand J Gastroenterol 2015 Jun;50(6):708-17. Epub 2015 apr 7
PMID: 25846940
Small bowel, celiac disease and adaptive immunity.
Dig Dis 2015;33(2):115-21. Epub 2015 apr 22
PMID: 25925911
Serologic Assay for Diagnosis of Celiac Disease Based on a Patient-Derived Monoclonal Antigliadin Antibody.
Gastroenterology 2015 Nov;149(6):1530-1540.e3. Epub 2015 jul 21
PMID: 26208894
Celiac disease: Autoimmunity in response to food antigen.
Semin Immunol 2015 Sep;27(5):343-52. Epub 2015 nov 18
PMID: 26603490
Biased usage and preferred pairing of a- and ß-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease.
Int Immunol 2014 Jan;26(1):13-9. Epub 2013 sep 13
PMID: 24038601
Advances in coeliac disease.
Curr Opin Gastroenterol 2014 Mar;30(2):154-62.
PMID: 24457347
How T cells taste gluten in celiac disease.
Nat Struct Mol Biol 2014 May;21(5):429-31. Epub 2014 apr 28
PMID: 24777059
Treatment of both native and deamidated gluten peptides with an endo-peptidase from Aspergillus niger prevents stimulation of gut-derived gluten-reactive T cells from either children or adults with celiac disease.
Clin Immunol 2014 Aug;153(2):323-31. Epub 2014 jun 3
PMID: 24905137
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells.
Nat Commun 2014;5():4041. Epub 2014 jun 9
PMID: 24909383
Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge.
United European Gastroenterol J 2014 Aug;2(4):268-78.
PMID: 25083284
Molecular mechanisms for contribution of MHC molecules to autoimmune diseases.
Curr Opin Immunol 2014 Dec;31C():24-30. Epub 2014 sep 15
PMID: 25216261
HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes.
J Immunol 2014 Nov 1;193(9):4497-506. Epub 2014 sep 26
PMID: 25261484
Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange.
Proc Natl Acad Sci U S A 2014 Dec 2;111(48):17146-51. Epub 2014 nov 17
PMID: 25404341
Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires.
Immunogenetics 2015 Feb;67(2):73-84. Epub 2014 des 12
PMID: 25502872
Antigen processing.
Curr Opin Immunol 2013 Feb;25(1):71-3. Epub 2013 jan 1
PMID: 23287556
Plasmacytoid dendritic cells are scarcely represented in the human gut mucosa and are not recruited to the celiac lesion.
Mucosal Immunol 2013 Sep;6(5):985-92. Epub 2013 jan 23
PMID: 23340820
Pitfalls in determining the cytokine profile of human T cells.
J Immunol Methods 2013 Apr 30;390(1-2):106-12. Epub 2013 feb 15
PMID: 23416458
Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity.
Am J Gastroenterol 2013 May;108(5):842-50. Epub 2013 apr 16
PMID: 23588237
Triggers and drivers of autoimmunity: lessons from coeliac disease.
Nat Rev Immunol 2013 Apr;13(4):294-302. Epub 2013 mar 15
PMID: 23493116
Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells.
J Immunol 2013 Jun 15;190(12):5981-91. Epub 2013 mai 20
PMID: 23690478
Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease.
Eur J Immunol 2013 Oct;43(10):2605-12. Epub 2013 jul 15
PMID: 23775608
Association Between Maternal Iron Supplementation During Pregnancy and Risk of Celiac Disease in Children.
Clin Gastroenterol Hepatol 2013 Oct 7. Epub 2013 okt 7
PMID: 24112997
T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease.
Gastroenterology 2012 Mar;142(3):552-61. Epub 2011 nov 19
PMID: 22108197
Activation and inhibition of transglutaminase 2 in mice.
PLoS One 2012;7(2):e30642. Epub 2012 feb 2
PMID: 22319575
Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules.
Immunogenetics 2012 Jun;64(6):455-60. Epub 2012 feb 10
PMID: 22322673
Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cells.
Hum Immunol 2012 Apr;73(4):376-81. Epub 2012 jan 31
PMID: 22342873
Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule.
J Biol Chem 2012 Apr;287(17):13611-9. Epub 2012 feb 23
PMID: 22362761
Rapid accumulation of CD14+CD11c+ dendritic cells in gut mucosa of celiac disease after in vivo gluten challenge.
PLoS One 2012;7(3):e33556. Epub 2012 mar 16
PMID: 22438948
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions.
Nat Med 2012 Mar;18(3):441-5. Epub 2012 feb 26
PMID: 22366952
The intestinal B-cell response in celiac disease.
Front Immunol 2012;3():313. Epub 2012 okt 4
PMID: 23060888
Integration of genetic and immunological insights into a model of celiac disease pathogenesis.
Annu Rev Immunol 2011 Apr;29():493-525.
PMID: 21219178
Assessing possible celiac disease by an HLA-DQ2-gliadin Tetramer Test.
Am J Gastroenterol 2011 Jul;106(7):1318-24. Epub 2011 mar 1
PMID: 21364548
Assessing high affinity binding to HLA-DQ2.5 by a novel peptide library based approach.
Bioorg Med Chem 2011 Apr;19(7):2470-7. Epub 2011 feb 2
PMID: 21382721
CD62L(neg)CD38? expression on circulating CD4? T cells identifies mucosally differentiated cells in protein fed mice and in human celiac disease patients and controls.
Am J Gastroenterol 2011 Jun;106(6):1147-59. Epub 2011 mar 8
PMID: 21386831
Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesion.
Scand J Immunol 2011 Aug;74(2):186-94.
PMID: 21392045
Novel therapies for coeliac disease.
J Intern Med 2011 Jun;269(6):604-13.
PMID: 21401739
Posttranslational modification of gluten shapes TCR usage in celiac disease.
J Immunol 2011 Sep;187(6):3064-71. Epub 2011 aug 17
PMID: 21849672
Activation of extracellular transglutaminase 2 by thioredoxin.
J Biol Chem 2011 Oct;286(43):37866-73. Epub 2011 sep 9
PMID: 21908620
Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders.
Curr Opin Immunol 2011 Dec;23(6):732-8. Epub 2011 sep 12
PMID: 21917438
Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells.
Gastroenterology 2011 Aug;141(2):610-20, 620.e1-2. Epub 2011 apr 28
PMID: 21683079
Long-lived plasma cells from human small intestine biopsies secrete immunoglobulins for many weeks in vitro.
J Immunol 2011 Sep;187(6):2867-74. Epub 2011 aug 12
PMID: 21841131
- Knut Erik Aslaksen Lundin Prosjektdeltaker
- Shuo-Wang Qiao Medveileder
- Ludvig Magne Sollid Prosjektleder
- Bjørg Simonsen Prosjektdeltaker
- Louise Fremgaard Risnes Doktorgradsstipendiat (finansiert av denne bevilgning)
- Øyvind Steinsbø Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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