Intracellular transport in malignant cells
- Prosjektnummer
- 2011066
- Ansvarlig person
- Kirsten Sandvig
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Helse Sør-Øst forskningsgruppe
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning, 4. Detection and Diagnosis
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Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation.
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Addition of lysophospholipids with large head groups to cells inhibits Shiga toxin binding.
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PIKfyve inhibition increases exosome release and induces secretory autophagy.
Cell Mol Life Sci 2016 Dec;73(24):4717-4737. Epub 2016 jul 20
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Determining the Turnover of Glycosphingolipid Species by Stable-Isotope Tracer Lipidomics.
J Mol Biol 2016 Dec 04;428(24 Pt A):4856-4866. Epub 2016 jun 27
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A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking.
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Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins.
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Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport.
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Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner.
Biochim Biophys Acta 2016 Feb;1858(2):281-8. Epub 2015 des 2
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Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic.
Cell Mol Life Sci 2016 Mar;73(6):1301-16. Epub 2015 sep 25
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Different roles of the C-terminal end of Stx1A and Stx2A for AB5 complex integrity and retrograde transport of Stx in HeLa cells.
Pathog Dis 2015 Dec;73(9):ftv083. Epub 2015 okt 5
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Novel actions of 2-deoxy-D-glucose: protection against Shiga toxins and changes in cellular lipids.
Biochem J 2015 Aug 15;470(1):23-37. Epub 2015 jun 11
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Cell-penetrating peptides: possibilities and challenges for drug delivery in vitro and in vivo.
Molecules 2015;20(7):13313-23. Epub 2015 jul 22
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Identification of prostate cancer biomarkers in urinary exosomes.
Oncotarget 2015 Oct 6;6(30):30357-76.
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The Role of Lectin-Carbohydrate Interactions in the Regulation of ER-Associated Protein Degradation.
Molecules 2015;20(6):9816-46. Epub 2015 mai 27
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Geldanamycin Enhances Retrograde Transport of Shiga Toxin in HEp-2 Cells.
PLoS One 2015;10(5):e0129214. Epub 2015 mai 27
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Novel Furin Inhibitors with Potent Anti-infectious Activity.
ChemMedChem 2015 Jul;10(7):1218-31. Epub 2015 mai 14
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Hydrophobicity of protein determinants influences the recognition of substrates by EDEM1 and EDEM2 in human cells.
BMC Cell Biol 2015;16():1. Epub 2015 feb 6
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The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells.
J Biol Chem 2015 Feb 13;290(7):4225-37. Epub 2014 des 17
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LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis.
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Development of nanoparticles for clinical use.
Nanomedicine (Lond) 2014 Jul;9(9):1295-9.
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Vps11, a subunit of the tethering complexes HOPS and CORVET, is involved in regulation of glycolipid degradation and retrograde toxin transport.
Commun Integr Biol 2014 Jan 1;7(1):e28129. Epub 2014 apr 3
PMID: 24778763
Flotillin depletion affects ErbB protein levels in different human breast cancer cells.
Biochim Biophys Acta 2014 Sep;1843(9):1987-96. Epub 2014 apr 18
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The fungal chimerolectin MOA inhibits protein and DNA synthesis in NIH/3T3 cells and may induce BAX-mediated apoptosis.
Biochem Biophys Res Commun 2014 May 16;447(4):586-9. Epub 2014 apr 18
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The ether lipid precursor hexadecylglycerol protects against Shiga toxins.
Cell Mol Life Sci 2014 Nov;71(21):4285-300. Epub 2014 apr 18
PMID: 24740796
Antibody-mediated inhibition of ricin toxin retrograde transport.
MBio 2014;5(2):e00995. Epub 2014 apr 8
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Regulation of exosome release by glycosphingolipids and flotillins.
FEBS J 2014 May;281(9):2214-27. Epub 2014 mar 21
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Lipid requirements for entry of protein toxins into cells.
Prog Lipid Res 2014 Apr;54():1-13. Epub 2014 jan 23
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The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol.
Biochem J 2014 Feb 1;457(3):485-96.
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Cell density-induced changes in lipid composition and intracellular trafficking.
Cell Mol Life Sci 2014 Mar;71(6):1097-116. Epub 2013 aug 7
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The ether lipid precursor hexadecylglycerol causes major changes in the lipidome of HEp-2 cells.
PLoS One 2013;8(9):e75904. Epub 2013 sep 30
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Molecular lipidomics of exosomes released by PC-3 prostate cancer cells.
Biochim Biophys Acta 2013 Jul;1831(7):1302-9.
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Retrograde transport of protein toxins through the Golgi apparatus.
Histochem Cell Biol 2013 Sep;140(3):317-26. Epub 2013 jun 14
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BiP negatively affects ricin transport.
Toxins (Basel) 2013 May;5(5):969-82. Epub 2013 mai 10
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The ERM proteins ezrin and moesin regulate retrograde Shiga toxin transport.
Traffic 2013 Jul;14(7):839-52. Epub 2013 mai 28
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Exosomal miRNAs as Biomarkers for Prostate Cancer.
Front Genet 2013;4():36. Epub 2013 mar 21
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Flotillins as regulators of ErbB2 levels in breast cancer.
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Genetic blockage of endocytic pathways reveals differences in the intracellular processing of non-viral gene delivery systems.
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Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells.
Biochim Biophys Acta 2012 Nov-Dec;1819(11-12):1154-63. Epub 2012 sep 8
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Shiga toxins.
Toxicon 2012 Nov;60(6):1085-107. Epub 2012 aug 16
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Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism.
J Nanobiotechnology 2012;10():33. Epub 2012 jul 31
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Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin.
PLoS One 2012;7(7):e40429. Epub 2012 jul 6
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Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.
J Biol Chem 2012 Jun;287(26):21992-2003. Epub 2012 apr 26
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Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3.
Mol Cell Proteomics 2012 Jul;11(7):M111.012914. Epub 2012 mar 28
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Inhibitors of intravesicular acidification protect against Shiga toxin in a pH-independent manner.
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Role of phospholipase a(2) in retrograde transport of ricin.
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Protein C mutation (A267T) results in ER retention and unfolded protein response activation.
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Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling.
PLoS One 2011;6(7):e21708. Epub 2011 jul 14
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Derlin-dependent retrograde transport from endosomes to the Golgi apparatus.
Traffic 2011 Oct;12(10):1417-31. Epub 2011 jul 27
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Marasmius oreades agglutinin (MOA) is a chimerolectin with proteolytic activity.
Biochem Biophys Res Commun 2011 May;408(3):405-10. Epub 2011 apr 12
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Clathrin-independent endocytosis: mechanisms and function.
Curr Opin Cell Biol 2011 Aug;23(4):413-20. Epub 2011 apr 3
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Shiga toxin and its use in targeted cancer therapy and imaging.
Microb Biotechnol 2011 Jan;4(1):32-46.
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A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation.
Biochem J 2011 Jun;436(2):371-85.
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Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells.
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Ricin and ricin-containing immunotoxins: insight into intracellular transport and mechanism of action in vitro
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Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies
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Membrane dynamics in cancer cells
- Disputert:
- september 2016
- Hovedveileder:
- Kirsten Sandvig
Shiga toxin: Uptake and transport in cancer cells
- Disputert:
- oktober 2015
- Hovedveileder:
- Kirsten Sandvig
Composition and cellular release of exosomes from cancer cells
- Disputert:
- januar 2014
- Hovedveileder:
- Alicia Llorente
Regulation of ErbB2 and ErbB3 growth factor receptors in human breast cancer
- Disputert:
- januar 2014
- Hovedveileder:
- Kirsten Sandvig
Ph.D.
- Disputert:
- mars 2012
- Hovedveileder:
- Kirsten Sandvig
- Ieva Ailte Doktorgradsstipendiat (annen finansiering)
- Audun Sverre Myrset Kvalvaag Prosjektdeltaker
- Anders Øverbye Prosjektdeltaker
- Maria Lyngaas Torgersen Prosjektdeltaker
- Sascha Pust Medveileder
- Tore Geir Iversen Prosjektdeltaker
- Alicia Llorente Prosjektdeltaker
- Tore Skotland Prosjektdeltaker
- Simona Kavaliauskiene Doktorgradsstipendiat (finansiert av denne bevilgning)
- Nina Pettersen Hessvik Prosjektdeltaker
- Kirsten Sandvig Prosjektleder
- Jonas Bergan Postdoktorstipendiat
- Tove Irene Klokk Postdoktorstipendiat
- Roger Simm Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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