Molecular studies of vitamin D responsive and other MS susceptibility genes
- Prosjektnummer
- 2012008
- Ansvarlig person
- Hanne F. Harbo
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Inflammatory and Immune System, Neurological
- Forskningsaktivitet
- 1. Underpinning
Nei
NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk.
Neuron 2016 Oct 19;92(2):333-335.
PMID: 27764667
Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood.
BMC Genet 2016 Apr 14;17():59. Epub 2016 apr 14
PMID: 27080863
From genetic associations to functional studies in multiple sclerosis.
Eur J Neurol 2016 May;23(5):847-53. Epub 2016 mar 7
PMID: 26948534
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.
Genes Immun 2016 Mar;17(2):118-27. Epub 2016 jan 14
PMID: 26765264
Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells.
PLoS One 2015;10(7):e0132957. Epub 2015 jul 23
PMID: 26203907
Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis.
PLoS One 2015;10(3):e0117403. Epub 2015 mar 3
PMID: 25734800
Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis.
J Neuroimmunol 2015 Jan 15;278():11-8. Epub 2014 nov 24
PMID: 25595247
Friedreich ataxia in Norway - an epidemiological, molecular and clinical study.
Orphanet J Rare Dis 2015;10():108. Epub 2015 sep 4
PMID: 26338206
The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.
Sci Signal 2014;7(355):ra118. Epub 2014 des 9
PMID: 25492967
Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general.
J Neuroimmunol 2014 Sep 15;274(1-2):174-9. Epub 2014 jul 6
PMID: 25037176
From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A.
Int J Mol Sci 2013;14(3):4476-97. Epub 2013 feb 25
PMID: 23439554
Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.
Genes Immun 2013 Jan;14(1):62-6. Epub 2012 nov 15
PMID: 23151489
Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles.
PLoS One 2013;8(3):e58352. Epub 2013 mar 5
PMID: 23472185
Identifying protein interaction partners for DEXI - encoded by the dexamethasone-induced gene, DEXI
Poster på nasjonal konferanse: Biokjemisk Kontaktmøte på Storefjell, janar 2017
Molecular characterization of TAGAP – a GTPase-activating protein encoded by a multiple sclerosis susceptibility gene
Poster på nasjonal konferanse; Biokjemisk Kontaktmøte på Storefjell, januar 2017
Gene expression in pathways enriched with MS associated risk loci
Muntlig presentasjon på nasjonal konferanse; Biokjemisk Kontaktmøte på Storefjell, januar 2017
DNA methylation differences in CD4+ and CD8+ T cells of multiple sclerosis patients and healthy controls
Poster på internasjonal konferanse; European conference on Human Genetics i København, mai 2017
Identifying protein interaction partners for DEXI - Encoded by the multiple sclerosis associated dexamethasone-induced gene, DEXI
Master oppgave - Institutt for Biovitenskap ved Universitetet i Oslo
Molecular characterization of T-cell activation Rho-GTPase activating protein - A protein encoded by multiple sclerosis susceptibility gene
Masteroppgave - Institutt for Biovitenskap ved Universitetet i Oslo
2017 Gene expression profiling of CD4+ T cells from multiple sclerosis patients and healthy controls
Poster på internasjonal konferanse; American Society of Human Genetics Conference, oktober 2017
Molekylære analyser av CLEC16A, et mottagelihetsgen ved multippel sklerose, i immunceller
Best Practice, 2015
Molecular characterization of the multiple sclerosis susceptibility gene CLEC16A
Posterpresentasjon, EMBO meeting i Amsterdam, September 2013
Characterization of multiple sclerosis susceptibility genes. Genetic and molecular studies in T cells
- Disputert:
- oktober 2015
- Hovedveileder:
- Tone Berge
- Ingvild Sørum Leikfoss Prosjektdeltaker
- Steffan Daniel Bos Prosjektdeltaker
- Hanne Flinstad Harbo Prosjektleder
- Tone Berge Postdoktorstipendiat (finansiert av denne bevilgning)
- Pankaj Kumar Keshari Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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