The relative role of Complement and CD14/Toll-like receptors in sepsis.
- Prosjektnummer
- 2012057
- Ansvarlig person
- Tom Eirik Mollnes
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Inflammatory and Immune System
- Forskningsaktivitet
- 5. Treatment Developement
A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.
Mol Immunol 2015 Mar;64(1):170-6. Epub 2014 des 19
PMID: 25534848
Massive Organ Inflammation in Experimental and in Clinical Meningococcal Septic Shock.
Shock 2015 Nov;44(5):458-69.
PMID: 26473439
Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood.
Innate Immun 2014 Jan;20(1):68-77. Epub 2013 mai 13
PMID: 23669326
Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice.
J Immunol 2014 Jun 1;192(11):5324-31. Epub 2014 apr 30
PMID: 24790148
Systemic CD14 inhibition attenuates organ inflammation in porcine Escherichia coli sepsis.
Infect Immun 2013 Sep;81(9):3173-81. Epub 2013 jun 17
PMID: 23774598
Combined inhibition of complement C5 and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis.
J Immunol 2013 Jul 15;191(2):819-27. Epub 2013 jun 12
PMID: 23761634
Clinical experience with microdialysis catheters in pediatric liver transplants.
Liver Transpl 2013 Mar;19(3):305-14.
PMID: 23193034
Polyvalent immunoglobulin significantly attenuated the formation of IL-1ß in Escherichia coli-induced sepsis in pigs.
Immunobiology 2013 May;218(5):683-9. Epub 2012 aug 9
PMID: 22947599
- Ebbe Billmann Thorgersen Prosjektdeltaker
- Tom Eirik Mollnes Prosjektleder
- Bernt C Hellerud Postdoktorstipendiat (finansiert av denne bevilgning)
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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