NASATS- How do genetic, clinical and treatment factors affect outcome in severe mental disorders?
- Prosjektnummer
- 2012131
- Ansvarlig person
- Ole A. Andreassen
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Nasats - prosjekt Nettverk
- Helsekategori
- Mental Health
- Forskningsaktivitet
- 2. Aetiology, 5. Treatment Developement
The Promise of Intranasal Esketamine as a Novel and Effective Antidepressant.
JAMA Psychiatry 2017 Dec 27. Epub 2017 des 27
PMID: 29282452
Diabetes and Schizophrenia-New Findings for an Old Puzzle.
Am J Psychiatry 2017 07 01;174(7):616-617.
PMID: 28669214
eHealth provides a novel opportunity to exploit the advantages of the Nordic countries in psychiatric genetic research, building on the public health care system, biobanks, and registries.
Am J Med Genet B Neuropsychiatr Genet 2017 Jul 07. Epub 2017 jul 7
PMID: 28686333
Brain volume change in first-episode psychosis: an effect of antipsychotic medication independent of BMI change.
Acta Psychiatr Scand 2017 Feb;135(2):117-126. Epub 2016 des 7
PMID: 27925164
Alcohol use is associated with thinner cerebral cortex and larger ventricles in schizophrenia, bipolar disorder and healthy controls.
Psychol Med 2017 Mar;47(4):655-668. Epub 2016 nov 10
PMID: 27830632
Persistent increase in TNF and IL-1 markers in severe mental disorders suggests trait-related inflammation: a one year follow-up study.
Acta Psychiatr Scand 2017 10;136(4):400-408. Epub 2017 aug 16
PMID: 28815548
Serum levels of second-generation antipsychotics are associated with cognitive function in psychotic disorders.
World J Biol Psychiatry 2017 Sep;18(6):471-482. Epub 2016 nov 15
PMID: 27712130
Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis.
Schizophr Res 2017 Nov 09. Epub 2017 nov 9
PMID: 29129510
Metabolic risk factors in schizophrenia and bipolar disorder: The effect of comedication with selective serotonin reuptake inhibitors and antipsychotics.
Eur Psychiatry 2018 02;48():71-78. Epub 2017 apr 17
PMID: 29331603
Early clinical recovery in first-episode psychosis: Symptomatic remission and its correlates at 1-year follow-up.
Psychiatry Res 2017 Aug;254():118-125. Epub 2017 apr 24
PMID: 28460281
An exploration of metacognitive beliefs and thought control strategies in bipolar disorder.
Compr Psychiatry 2017 Feb;73():84-92. Epub 2016 nov 23
PMID: 27918949
Vitamin D Deficiency Associated With Cognitive Functioning in Psychotic Disorders.
J Clin Psychiatry 2017 Jul;78(7):e750-e757.
PMID: 28493652
Body language reading of emotion in schizophrenia: Associations with symptoms and functional outcome.
Scand J Psychol 2017 Oct;58(5):359-366. Epub 2017 aug 22
PMID: 28833180
Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study.
Bipolar Disord 2018 05;20(3):228-237. Epub 2017 nov 9
PMID: 29121444
Course of neurocognitive function in first treatment bipolar I disorder: One-year follow-up study.
Psychiatry Res 2017 Mar;249():286-292. Epub 2016 des 31
PMID: 28142102
Impairment in emotion perception from body movements in individuals with bipolar I and bipolar II disorder is associated with functional capacity.
Int J Bipolar Disord 2017 Dec;5(1):13. Epub 2017 jun 21
PMID: 28332121
Childhood Trauma and Minimization/Denial in People with and without a Severe Mental Disorder.
Front Psychol 2017;8():1276. Epub 2017 aug 24
PMID: 28883800
Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders.
Psychol Med 2017 Mar;47(4):669-679. Epub 2016 nov 11
PMID: 27834153
Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses.
Brain Behav Immun 2017 Oct;65():342-349. Epub 2017 jun 13
PMID: 28619247
A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue.
Schizophr Bull 2017 Jul 01;43(4):881-890.
PMID: 28049760
Correlation Between Serum Concentrations of N-Desmethylclozapine and Granulocyte Levels in Patients with Schizophrenia: A Retrospective Observational Study.
CNS Drugs 2017 Nov;31(11):991-997.
PMID: 28948574
Causes and predictors of premature death in first-episode schizophrenia spectrum disorders.
World Psychiatry 2017 Jun;16(2):217-218.
PMID: 28498600
Is going into stable symptomatic remission associated with a more positive development of life satisfaction? A 10-year follow-up study of first episode psychosis.
Schizophr Res 2018 03;193():364-369. Epub 2017 jul 9
PMID: 28701275
Metacognitive beliefs mediate the effect of emotional abuse on depressive and psychotic symptoms in severe mental disorders.
Psychol Med 2017 Oct;47(13):2323-2333. Epub 2017 apr 11
PMID: 28397634
Affective lability mediates the association between childhood trauma and suicide attempts, mixed episodes and co-morbid anxiety disorders in bipolar disorders.
Psychol Med 2017 Apr;47(5):902-912. Epub 2016 nov 29
PMID: 27894372
Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.
Nat Genet 2017 Jan;49(1):152-156. Epub 2016 des 5
PMID: 27918536
Identification of Gene Loci That Overlap Between Schizophrenia and Educational Attainment.
Schizophr Bull 2017 05 01;43(3):654-664.
PMID: 27338279
Identification of genetic loci shared between schizophrenia and the Big Five personality traits.
Sci Rep 2017 May 22;7(1):2222. Epub 2017 mai 22
PMID: 28533504
Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms.
Schizophr Bull 2018 06 06;44(4):854-864.
PMID: 29136250
Identification of Genetic Loci Jointly Influencing Schizophrenia Risk and the Cognitive Traits of Verbal-Numerical Reasoning, Reaction Time, and General Cognitive Function.
JAMA Psychiatry 2017 Oct 01;74(10):1065-1075.
PMID: 28746715
The Effect of Substance Use on 10-Year Outcome in First-Episode Psychosis.
Schizophr Bull 2017 Jul 01;43(4):843-851.
PMID: 28199703
"With a little help from my friends" social predictors of clinical recovery in first-episode psychosis.
Psychiatry Res 2017 Sep;255():209-214. Epub 2017 mai 30
PMID: 28578180
Antipsychotic treatment: experiences of fully recovered service users.
J Ment Health 2017 Jun;26(3):264-270. Epub 2017 mar 1
PMID: 28602144
Experiences of antipsychotic use in patients with early psychosis: a two-year follow-up study.
BMC Psychiatry 2017 Aug 22;17(1):299. Epub 2017 aug 22
PMID: 28830453
Right unilateral electroconvulsive therapy does not cause more cognitive impairment than pharmacologic treatment in treatment-resistant bipolar depression: A 6-month randomized controlled trial follow-up study.
Bipolar Disord 2017 Dec 21. Epub 2017 des 21
PMID: 29267990
Variability of activity patterns across mood disorders and time of day.
BMC Psychiatry 2017 Dec 19;17(1):404. Epub 2017 des 19
PMID: 29258468
Solar insolation in springtime influences age of onset of bipolar I disorder.
Acta Psychiatr Scand 2017 Dec;136(6):571-582. Epub 2017 jul 19
PMID: 28722128
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.
Transl Psychiatry 2017 Jun 20;7(6):e1155. Epub 2017 jun 20
PMID: 28632202
A pilot study to determine whether combinations of objectively measured activity parameters can be used to differentiate between mixed states, mania, and bipolar depression.
Int J Bipolar Disord 2017 Dec;5(1):5. Epub 2017 mar 1
PMID: 28155205
Activation in Bipolar Disorders: A Systematic Review.
JAMA Psychiatry 2017 Feb 01;74(2):189-196.
PMID: 28002572
High levels of anomalous self-experience are associated with longer duration of untreated psychosis.
Early Interv Psychiatry 2017 04;11(2):133-138. Epub 2015 jan 15
PMID: 25589153
Onconeural Antibodies in Acute Psychiatric Inpatient Care.
J Neuropsychiatry Clin Neurosci 2017 Winter;29(1):74-76. Epub 2016 aug 31
PMID: 27578448
Influence of different second generation antipsychotics on the QTc interval: A pragmatic study.
World J Psychiatry 2016 Dec 22;6(4):442-448. Epub 2016 des 22
PMID: 28078208
The Course of Neurocognitive Changes in Acute Psychosis: Relation to Symptomatic Improvement.
PLoS One 2016;11(12):e0167390. Epub 2016 des 15
PMID: 27977720
The serum level of C-reactive protein (CRP) is associated with cognitive performance in acute phase psychosis.
BMC Psychiatry 2016 Mar 14;16():60. Epub 2016 mar 14
PMID: 26973142
Patient satisfaction after acute admission for psychosis.
Nord J Psychiatry 2016 Jul;70(5):321-8. Epub 2016 jan 11
PMID: 26750532
Cannabis use is associated with 3years earlier onset of schizophrenia spectrum disorder in a naturalistic, multi-site sample (N=1119).
Schizophr Res 2016 Jan;170(1):217-21. Epub 2015 des 9
PMID: 26682958
Distribution and Characteristics of Active and Inactive Periods Distinguish Unipolar Depression With and Without Motor Retardation.
J Clin Psychiatry 2016 Jun;77(6):841-2.
PMID: 27337419
The long-term outcomes of an effectiveness trial of group versus individual psychoeducation for bipolar disorders.
J Affect Disord 2016 Sep 15;202():32-8. Epub 2016 mai 24
PMID: 27253214
Sleep patterns as a predictor for length of stay in a psychiatric intensive care unit.
Psychiatry Res 2016 Mar 30;237():252-6. Epub 2016 jan 16
PMID: 26805566
Delayed sleep phase: An important circadian subtype of sleep disturbance in bipolar disorders.
J Affect Disord 2016 Feb;191():156-63. Epub 2015 nov 24
PMID: 26655861
Sleep problems in bipolar disorders: more than just insomnia.
Acta Psychiatr Scand 2016 May;133(5):368-77. Epub 2015 nov 21
PMID: 26590799
Duration of untreated illness in first-treatment bipolar I disorder in relation to clinical outcome and cannabis use.
Psychiatry Res 2016 Dec 30;246():762-768. Epub 2016 okt 28
PMID: 27814886
History of psychosis and previous episodes as potential explanatory factors for neurocognitive impairment in first-treatment bipolar I disorder.
Bipolar Disord 2016 Mar;18(2):136-47. Epub 2016 mar 18
PMID: 26990158
Rich semantic networks applied to schizophrenia: A new framework.
Schizophr Res 2016 Oct;176(2-3):454-5. Epub 2016 mai 28
PMID: 27245710
A genetic association study of CSMD1 and CSMD2 with cognitive function.
Brain Behav Immun 2017 Mar;61():209-216. Epub 2016 nov 25
PMID: 27890662
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Nat Neurosci 2016 Mar;19(3):420-31. Epub 2016 feb 1
PMID: 26854805
Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS.
PLoS Genet 2016 Jan;12(1):e1005803. Epub 2016 jan 25
PMID: 26808560
Continued cannabis use at one year follow up is associated with elevated mood and lower global functioning in bipolar I disorder.
BMC Psychiatry 2015;15():11. Epub 2015 feb 5
PMID: 25651990
Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci.
Mol Psychiatry 2015 Feb;20(2):207-14. Epub 2014 jan 28
PMID: 24468824
Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons.
PLoS One 2015;10(11):e0143432. Epub 2015 nov 20
PMID: 26587987
Microarray Analysis of Copy Number Variants on the Human Y Chromosome Reveals Novel and Frequent Duplications Overrepresented in Specific Haplogroups.
PLoS One 2015;10(8):e0137223. Epub 2015 aug 31
PMID: 26322892
MicroRNAs enrichment in GWAS of complex human phenotypes.
BMC Genomics 2015;16():304. Epub 2015 apr 16
PMID: 25884492
Polygenic risk scores in bipolar disorder subgroups.
J Affect Disord 2015 Sep 1;183():310-4. Epub 2015 mai 22
PMID: 26047958
Actigraphically assessed activity in unipolar depression: a comparison of inpatients with and without motor retardation.
J Clin Psychiatry 2015 Sep;76(9):1181-7.
PMID: 26214574
The role of insomnia in the treatment of chronic fatigue.
J Psychosom Res 2015 May;78(5):427-32. Epub 2014 des 5
PMID: 25498318
Suicidality in schizophrenia spectrum disorders: the relationship to hallucinations and persecutory delusions.
Eur Psychiatry 2015 Oct;30(7):830-6. Epub 2015 sep 25
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Glutamate as a mediating transmitter for auditory hallucinations in schizophrenia: a (1)H MRS study.
Schizophr Res 2015 Feb;161(2-3):252-60. Epub 2014 des 24
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Auditory verbal hallucinations reflect stable auditory attention deficits: a prospective study.
Cogn Neuropsychiatry 2015;20(1):81-94.
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Relationship of suicide rates to economic variables in Europe: 2000-2011.
Br J Psychiatry 2014 Dec;205(6):486-96. Epub 2014 okt 30
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Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls.
J Affect Disord 2014 Oct 23;172C():375-380. Epub 2014 okt 23
PMID: 25451440
Interplay between childhood trauma and BDNF val66met variants on blood BDNF mRNA levels and on hippocampus subfields volumes in schizophrenia spectrum and bipolar disorders.
J Psychiatr Res 2014 Dec;59():14-21. Epub 2014 aug 30
PMID: 25246365
Risk factors of cycle acceleration in acutely admitted patients with bipolar disorder.
Acta Psychiatr Scand 2014 Nov;130(5):388-96. Epub 2014 jun 24
PMID: 24962060
Polygenic risk score and the psychosis continuum model.
Acta Psychiatr Scand 2014 Oct;130(4):311-7. Epub 2014 jun 25
PMID: 24961959
ANK3 gene expression in bipolar disorder and schizophrenia.
Br J Psychiatry 2014 Sep;205(3):244-5. Epub 2014 mai 8
PMID: 24809399
Cannabis use in first-treatment bipolar I disorder: relations to clinical characteristics.
Early Interv Psychiatry 2016 Feb;10(1):36-44. Epub 2014 apr 17
PMID: 24739233
Association analysis between suicidal behaviour and candidate genes of bipolar disorder and schizophrenia.
J Affect Disord 2014 Jul;163():110-4. Epub 2013 des 27
PMID: 24461634
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
Mol Psychiatry 2014 Sep;19(9):1017-24. Epub 2013 nov 26
PMID: 24280982
Indications of a dose-response relationship between cannabis use and age at onset in bipolar disorder.
Psychiatry Res 2014 Jan 30;215(1):101-4. Epub 2013 okt 30
PMID: 24262665
Additive effects of childhood abuse and cannabis abuse on clinical expressions of bipolar disorders.
Psychol Med 2014 Jun;44(8):1653-62. Epub 2013 sep 13
PMID: 24028906
Biological insights from 108 schizophrenia-associated genetic loci.
Nature 2014 Jul 24;511(7510):421-7. Epub 2014 jul 22
PMID: 25056061
Actigraphic assessment of motor activity in acutely admitted inpatients with bipolar disorder.
PLoS One 2014;9(2):e89574. Epub 2014 feb 20
PMID: 24586883
Cognitive behavioral therapy for insomnia in euthymic bipolar disorder: study protocol for a randomized controlled trial.
Trials 2014;15():24. Epub 2014 jan 16
PMID: 24433249
The Cannabis Pathway to Non-Affective Psychosis may Reflect Less Neurobiological Vulnerability.
Front Psychiatry 2014;5():159. Epub 2014 nov 18
PMID: 25477825
Time to discontinuation of antipsychotic drugs in a schizophrenia cohort: influence of current treatment strategies.
Ther Adv Psychopharmacol 2014 Dec;4(6):228-39.
PMID: 25489474
A critical review of pro-cognitive drug targets in psychosis: convergence on myelination and inflammation.
Front Psychiatry 2014;5():11. Epub 2014 feb 4
PMID: 24550848
Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.
J Affect Disord 2014 Oct 12;172C():453-461. Epub 2014 okt 12
PMID: 25451450
Impact of glutamate levels on neuronal response and cognitive abilities in schizophrenia.
Neuroimage Clin 2014;4():576-84. Epub 2014 apr 2
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Stratified medicine for mental disorders.
Eur Neuropsychopharmacol 2014 Jan;24(1):5-50. Epub 2013 okt 4
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Latent semantic variables are associated with formal thought disorder and adaptive behavior in older inpatients with schizophrenia.
Cortex 2014 Jun;55():88-96. Epub 2013 feb 19
PMID: 23510635
Neural correlates of the relationship between discourse coherence and sensory monitoring in schizophrenia.
Cortex 2014 Jun;55():77-87. Epub 2013 jul 22
PMID: 23969195
What do we really know about blunted vocal affect and alogia? A meta-analysis of objective assessments.
Schizophr Res 2014 Nov;159(2-3):533-8. Epub 2014 sep 26
PMID: 25261880
Category fluency, latent semantic analysis and schizophrenia: a candidate gene approach.
Cortex 2014 Jun;55():182-91. Epub 2013 des 20
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No evidence for association between bipolar disorder risk gene variants and brain structural phenotypes.
J Affect Disord 2013 Oct;151(1):291-7. Epub 2013 jun 29
PMID: 23820096
All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs.
PLoS Genet 2013 Apr;9(4):e1003449. Epub 2013 apr 25
PMID: 23637621
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Lancet 2013 Apr 20;381(9875):1371-9. Epub 2013 feb 28
PMID: 23453885
Neurocognitive features in subgroups of bipolar disorder.
Bipolar Disord 2013 May;15(3):272-83. Epub 2013 mar 25
PMID: 23521608
Social functioning in first contact mania: clinical and neurocognitive correlates.
Compr Psychiatry 2013 Jul;54(5):432-8. Epub 2013 jan 22
PMID: 23351832
Hvordan ungdom og unge voksne som står i fare for å utvikle psykose, opplever egen skole og sosial fungering, etter å ha deltatt i psykoedukativ familiebehandling. En kvalitativ studie
Nordisk Sygeplejeforskning, ÅRGANG 7, NR. 1-2017, S. 35–47 DOI: 10.18261/ISSN.1892-2686-2017-01-04
- Ole Andreas Andreassen Prosjektdeltaker
- Brita Elvevåg Forskningsgruppeleder
- Erik Johnsen Forskningsgruppeleder
- Ingrid Melle Forskningsgruppeleder
- Gunnar Morken Forskningsgruppeleder
- Christine Demmo Doktorgradsstipendiat
- Brita Elvevaag Forskningsgruppeleder
- Ketil Joachim Ødegaard Forskningsgruppeleder
- Liss-Gøril Anda-Ågotnes Doktorgradsstipendiat
- Igne Sinkevicute Doktorgradsstipendiat
- Håvard Kallestad Postdoktorstipendiat
- Karoline Krane-Gartesier Doktorgradsstipendiat
- Mette Kvisten Steinan Doktorgradsstipendiat
- Christine Nyquist Doktorgradsstipendiat
- Vidje Hansen Forsker (annen finansiering)
- Siri Selvik Kruse Prosjektdeltaker
- Ibrahim Akkouh Prosjektdeltaker
- Hilde Therese Juvodden Doktorgradsstipendiat
- Franscesco Bettella Postdoktorstipendiat
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