LOOPS - Mapping the Vessel Architecture of Cancer
- Prosjektnummer
- 2013069
- Ansvarlig person
- Kyrre Eeg Emblem
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Karrierestipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis
NEI
The Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma.
Sci Rep 2019 Dec 27;9(1):19898. Epub 2019 des 27
PMID: 31882644
Robust association between vascular habitats and patient prognosis in glioblastoma: An international multicenter study.
J Magn Reson Imaging 2020 05;51(5):1478-1486. Epub 2019 okt 26
PMID: 31654541
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.
Nat Biomed Eng 2019 03;3(3):230-245. Epub 2019 jan 7
PMID: 30948807
Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach.
Neuroradiology 2019 May;61(5):545-555. Epub 2019 feb 2
PMID: 30712139
Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI.
Sci Rep 2018 Nov 20;8(1):17062. Epub 2018 nov 20
PMID: 30459364
Brain metastases with poor vascular function are susceptible to pseudoprogression after stereotactic radiation surgery.
Adv Radiat Oncol 2018 Oct-Dec;3(4):559-567. Epub 2018 mai 17
PMID: 30370356
Towards patient-specific modeling of brain tumor growth and formation of secondary nodes guided by DTI-MRI.
Neuroimage Clin 2018;20():664-673. Epub 2018 aug 31
PMID: 30211003
Is deep brain involvement in intracranial primary central nervous system lymphoma of importance for penetration of chemotherapeutic agents?
Neuroradiology 2018 Jul;60(7):703-713. Epub 2018 mai 27
PMID: 29804159
Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma.
J Neurooncol 2017 02;131(3):603-610. Epub 2016 nov 16
PMID: 27853960
A theoretical framework for determining cerebral vascular function and heterogeneity from dynamic susceptibility contrast MRI.
J Cereb Blood Flow Metab 2017 Jun;37(6):2237-2248. Epub 2017 jan 1
PMID: 28273722
Non-invasive assessment of pulsatile intracranial pressure with phase-contrast magnetic resonance imaging.
PLoS One 2017;12(11):e0188896. Epub 2017 nov 30
PMID: 29190788
Early changes in glioblastoma metabolism measured by MR spectroscopic imaging during combination of anti-angiogenic cediranib and chemoradiation therapy are associated with survival.
NPJ Precis Oncol 2017;1(). Epub 2017 jun 12
PMID: 29202103
Improving treatment of liver metastases by targeting nonangiogenic mechanisms.
Nat Med 2016 Nov 08;22(11):1209-1210.
PMID: 27824818
Vascular Magnetic Resonance Imaging in Brain Tumors During Antiangiogenic Therapy--Are We There Yet?
Cancer J 2015 Jul-Aug;21(4):337-42.
PMID: 26222087
Repeatability of Cerebral Perfusion Using Dynamic Susceptibility Contrast MRI in Glioblastoma Patients.
Transl Oncol 2015 Jun;8(3):137-46.
PMID: 26055170
Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma.
J Clin Oncol 2015 Apr 1;33(10):1197-213. Epub 2015 feb 23
PMID: 25713439
A generic support vector machine model for preoperative glioma survival associations.
Radiology 2015 Apr;275(1):228-34. Epub 2014 des 8
PMID: 25486589
Advanced magnetic resonance imaging of the physical processes in human glioblastoma.
Cancer Res 2014 Sep 1;74(17):4622-37.
PMID: 25183787
Vessel caliber--a potential MRI biomarker of tumour response in clinical trials.
Nat Rev Clin Oncol 2014 Oct;11(10):566-84. Epub 2014 aug 12
PMID: 25113840
Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation.
Oncologist 2014 Jan;19(1):75-81. Epub 2013 des 5
PMID: 24309981
Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.
Nat Med 2013 Sep;19(9):1178-83. Epub 2013 aug 18
PMID: 23955713
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation.
Proc Natl Acad Sci U S A 2013 Nov 19;110(47):19059-64. Epub 2013 nov 4
PMID: 24190997
Perfusion Techniques
Book chapter in Mannil M, Winklhofer S (editors), Neuroimaging Techniques in Clinical Practice, Vol 1 (Chapter 12). Springer, 2019 (in press)
Dynamic Susceptibility Contrast MRI: Basic Physics, Pulse Sequences and Modelling
Book chapter in Seiberlich N, Gulani V (editors), Quantitative MRI: Principles and Applications, Vol 1, Elsevier/ Academic Press, 2019 (in press)
In vivo Assessment of Gray Matter Stiffness and Perfusion in the Human Brain.
Proc Annual Meeting International Society for Magnetic Resonance in Medicine, 2019
Preliminary results of the ONCOhabitats Study NCT03439332: A multicenter validation of overall survival estimation of patients with glioblastoma using vascular biomarkers.
Proc Annual Meeting American Association for Cancer Research, 2019
Imaging Perfusion Restrictions from Extracellular Solid Stress.
European Society of Neuroradiology (ESNR) Annual Meeting, 19-22 September 2019, Oslo, Norway
Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III
Journal of computer assisted tomography 2018 Sep-Oct 42 (5), 807-815
Diffusion dependency of oxygenation measurements obtained with Vessel Architectural Imaging.
Proc annual meeting ISMRM 2018, Paris, France
Template Maps of Vascular Function and Structure in the Healthy Brain
Proc annual meeting ISMRM 2018, Paris, France
Brain Metastases Developing Pseudoprogression have Poor Vascular Function and Supply,
Proc annual meeting ISMRM 2018, Paris, France
Bruk av avanserte MR-teknikker for forbedret responsevaluering og behandling av pasienter med hjernekreft.
Onkonytt 2018; Årgang 16; p.12-14
Adding angiotensin-system inhibitors to anti-angiogenic therapy reduces vasogenic edema in newly diagnosed glioblastomas but not in recurrent disease
Cancer Research 77 (2 Supplement), B12-B12, 2017
Vascular Responses to Pembrolizumab and Ipilimumab in Patients with Metastases to the Brain Receiving Stereotactic Radiosurgery
EACR-AACR-SIC Special Conference on The Challenges of Optimising Immuno and Targeted Therapies from Cancer Biology to the Clinic, Florence, Italy 24 – 27 June, 2017
Compressive stresses exerted by brain tumors impair vascular perfusion and induce neuronal damage in the normal surrounding tissue
The Biomedical Engineering Society Annual Meeting, October 11-14, 2017, Phoenix, Az, USA
Survival Associations by Dynamic Susceptibility Contrast MRI and Diffusion MRI in Patients with Oligodendroglial Tumors.
American Society for Neuroradiology (ASNR) Annual Meeting, April 24 - 27, 2017, Long Beach, California, USA
Metabolic and functional MR imaging probe early response in glioblastoma patients treated with combination antiangiogenic-chemoradiation therapy
International Society of Magnetic Resonance in Medicine Annual Meeting, 22-27 April, 2017, Honolulu, Hawaii, USA
Repeatability of ktrans derived from DCE-MRI in newly diagnosed glioblastoma across multiple baseline images and processing methods.
International Society of Magnetic Resonance in Medicine Annual Meeting, 22-27 April, 2017, Honolulu, Hawaii, USA
Insufficient Vascular Function and Supply Renders Brain Metastases Prone to Radionecrosis After Stereotactic Radiotherapy
Cancer Study Group Meeting, International Society of Magnetic Resonance in Medicine Annual Meeting, 22-27 April, 2017, Honolulu, Hawaii, USA
Matrix-depleting Anti-hypertensives Decompress Tumor Blood Vessels and Improve Perfusion in Patients with Glioblastomas [...]
Cancer Research 2016; 76 (14 Supplement), 3975
Immunotherapy Revised; Ipilimumab Potentiates the Vascular Response to Stereotactic Radiosurgery in Patients with Brain [...]
Cancer Research 2016; 76 (14 Supplement), 1471
Test-retest stability of MTT insensitive CBV leakage correction in DSC-MRI.
Proc Annual Meeting International Society for Magnetic Resonance in Medicine, 2016
Adding angiotensin-system inhibitors to anti-angiogenic therapy reduces vasogenic edema in newly diagnosed glioblastomas [...]
Cancer Research 2016; 77 (2 Supplement), B12
Radiolabeled temozolomide can measure bevacizumab induced vascular modulation in patients with recurrent GBM.
Proc Annual Meeting Society for Neuro-Oncology, 2015.
Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma.
Proc Annual Meeting American Society for Clinical Oncology, 2015
Perfusion MRI: A potential biomarker of tumor response in clinical trials.
Proc American Association for Cancer Research conference on Tumor Angiogenesis and Vascular Normalization: Bench to Bedside to Biomarkers, 2015
Abnormal Tumor and Peritumor Vasculature and Metabolism Differentiate Primary from Metastatic Malignant Brain Tumors
Proc Annual Meeting International Society for Magnetic Resonance in Medicine, 2015.
Lessons from Anti-VEGF/VEGFR Trials in Glioblastoma Patients.
J Clin Oncol 2014
Architectural Imaging Reveals Early Vascular Response to Anti-angiogenic Therapy.
Proc The New York Academy of Sciences - Targeting VEGF-mediated Tumor Angiogenesis in Cancer Therapy 2014
Brain Breast Metastases Respond to Anti-angiogenic Therapy by Modes of Vascular Normalization.
Proc Annual Meeting Society for Neuro-Oncology 2014
Increased perfusion due to vascular normalization improves oxygenation and survival in glioblastoma patients [...]
Proc International Conference on Brain Tumor Research and Therapy, Lake Tahoe, California, 2014.
Identification of Arterio-Venous Shunts by Vessel Architectural Imaging Reveals Mechanisms of Vascular Normalization [...]
Proc Annual Meeting International Society for Magnetic Resonance in Medicine, 2014.
Glioblastoma patients with arterio-venous normalization during anti-angiogenic therapy have prolonged survival
European Journal of Cancer 49;S29, 2013
Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy
Proc Annual Meeting American Association for Cancer Research (Minisymposium - Biomarkers of Clinical Response), 2013
Repeatability of MR-Based Vessel Caliber Estimates in Brain Tumor Imaging.
Proc Annual Meeting American Society of Neuroradiology, 2013
Repeatability of Cerebral Perfusion Measurements Using Susceptibility Contrast MRI.
Proc Annual Meeting International Society for Magnetic Resonance in Medicine, 2013
- Paulina Due-Tønnessen Prosjektdeltaker
- Einar O. Vik-Mo Prosjektdeltaker
- Torstein Ragnar Meling Prosjektdeltaker
- Pål Kjeldsen Brukerrepresentant
- Rakesh K. Jain Prosjektdeltaker
- Nancy C. Lin Prosjektdeltaker
- Elizabeth Gerstner Prosjektdeltaker
- Martion Bührer Prosjektdeltaker
- Christian Farrar Prosjektdeltaker
- Otto Rapalino Prosjektdeltaker
- Bruce Rosen Prosjektdeltaker
- Hans-Jørgen Smith Prosjektdeltaker
- Asta Kristine Håberg Prosjektdeltaker
- Atle Bjørnerud Medveileder
- Ingrid Digernes Doktorgradsstipendiat (finansiert av denne bevilgning)
- Kyrre Eeg Emblem Prosjektleder
- Fredric A A Courivaud Prosjektdeltaker
- Rakesh Jain Prosjektdeltaker
- Christopher Farrar Prosjektdeltaker
- Guro Kahrs Rognsvåg Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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