TRANSGENIC ANIMALS AND PHENOMICS
- Prosjektnummer
- 2013091
- Ansvarlig person
- Arne Klungland
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Regional teknologisk kjernefasilitet
- Helsekategori
- Forskningsaktivitet
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.
Nucleic Acids Res 2014 Dec 1;42(21):13280-93. Epub 2014 okt 29
PMID: 25355512
ALKBH4 depletion in mice leads to spermatogenic defects.
PLoS One 2014;9(8):e105113. Epub 2014 aug 25
PMID: 25153837
Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21.
Free Radic Biol Med 2014 Dec;77():41-8. Epub 2014 sep 16
PMID: 25236744
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age.
PLoS One 2014;9(5):e96940. Epub 2014 mai 12
PMID: 24819950
Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells.
Stem Cell Res 2013 Nov;11(3):1264-71. Epub 2013 aug 27
PMID: 24041806
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
Nat Commun 2013;4():1832.
PMID: 23673617
Tzfp represses the androgen receptor in mouse testis.
PLoS One 2013;8(4):e62314. Epub 2013 apr 25
PMID: 23634227
Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases.
RNA Biol 2013 Jun;10(6):915-8. Epub 2013 apr 17
PMID: 23619745
Deletion of mouse Alkbh7 leads to obesity.
J Mol Cell Biol 2013 Jun;5(3):194-203. Epub 2013 apr 8
PMID: 23572141
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Mol Cell 2013 Jan 10;49(1):18-29. Epub 2012 nov 21
PMID: 23177736
Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress.
Biochim Biophys Acta 2013 May;1833(5):1157-64. Epub 2013 jan 7
PMID: 23305905
Altered expression of genes involved in lipid metabolism in obese subjects with unfavourable phenotype.
Genes Nutr 2013 Jul;8(4):425-34. Epub 2013 jan 8
PMID: 23296345
Fatty acids regulate perilipin5 in muscle by activating PPARd.
J Lipid Res 2013 Jul;54(7):1949-63. Epub 2013 apr 20
PMID: 23606724
Physiological Roles of Mouse Alkbh7: Implications in Obesity and Running Endurance.
- Disputert:
- august 2013
- Hovedveileder:
- Arne Klungland
- Gaute Nesse Prosjektdeltaker
- Ingunn Jermstad Prosjektdeltaker
- Tara Catterall Prosjektdeltaker
- Shaista Khan Prosjektdeltaker
- Inna Johnson Prosjektdeltaker
- Knut Tomas Dalen Prosjektleder
- Arne Klungland Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport