Hypoxia and reoxygenation of the newborn: clinical and experimental studies
- Prosjektnummer
- 2013120
- Ansvarlig person
- Ola Didrik Saugstad
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Reproductive Health and Childbirth
- Forskningsaktivitet
- 5. Treatment Developement
Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia.
PLoS One 2018;13(11):e0206601. Epub 2018 nov 26
PMID: 30475817
Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets.
J Perinat Med 2018 Dec 19;47(1):82-89.
PMID: 30110254
DHA and therapeutic hypothermia in a short-term follow-up piglet model of hypoxia-ischemia: Effects on H+MRS biomarkers.
PLoS One 2018;13(8):e0201895. Epub 2018 aug 7
PMID: 30086156
DHA reduces oxidative stress following hypoxia-ischemia in newborn piglets: a study of lipid peroxidation products in urine and plasma.
J Perinat Med 2018 Feb 23;46(2):209-217.
PMID: 28632497
Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide.
Dis Markers 2018;2018():5046372. Epub 2018 jan 30
PMID: 29651324
Hyperoxia induces epigenetic changes in newborn mice lungs.
Free Radic Biol Med 2018 Jun;121():51-56. Epub 2018 apr 23
PMID: 29698744
Main title: pulmonary vascular disease is evident in gene regulation of experimental bronchopulmonary dysplasia.
J Matern Fetal Neonatal Med 2018 Nov 14. Epub 2018 nov 14
PMID: 30428746
An iTRAQ-Based Quantitative Proteomic Analysis of Plasma Proteins in Preterm Newborns With Retinopathy of Prematurity.
Invest Ophthalmol Vis Sci 2018 Nov 01;59(13):5312-5319.
PMID: 30398622
Plasma proteome changes in cord blood samples from preterm infants.
J Perinatol 2018 Sep;38(9):1182-1189. Epub 2018 jun 18
PMID: 29910464
Prospective plasma proteome changes in preterm infants with different gestational ages.
Pediatr Res 2018 Jul;84(1):104-111. Epub 2018 mai 23
PMID: 29795197
Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation.
J Perinat Med 2018 Dec 19;47(1):114-124.
PMID: 30020889
Oxygen and preterm infant resuscitation: what else do we need to know?
Curr Opin Pediatr 2018 04;30(2):192-198.
PMID: 29406439
Outcomes of oxygen saturation targeting during delivery room stabilisation of preterm infants.
Arch Dis Child Fetal Neonatal Ed 2018 Sep;103(5):F446-F454. Epub 2017 okt 7
PMID: 28988158
A review of international clinical practice guidelines for the use of oxygen in the delivery room resuscitation of preterm infants.
Acta Paediatr 2018 Jan;107(1):20-27. Epub 2017 sep 6
PMID: 28792628
Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs.
Nucl Med Biol 2018 11;66():49-57. Epub 2018 aug 24
PMID: 30257223
Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets.
Neonatology 2017;111(2):133-139. Epub 2016 okt 18
PMID: 27750254
High-Dose Cannabidiol Induced Hypotension after Global Hypoxia-Ischemia in Piglets.
Neonatology 2017;112(2):143-149. Epub 2017 jun 1
PMID: 28564654
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia.
Neonatology 2017;111(1):12-21. Epub 2016 aug 6
PMID: 27497671
Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia.
Redox Biol 2017 Aug;12():1-7. Epub 2017 feb 7
PMID: 28209514
DHA Reduces Oxidative Stress after Perinatal Asphyxia: A Study in Newborn Piglets.
Neonatology 2017;112(1):1-8. Epub 2017 feb 1
PMID: 28142140
Fish Oil in Pregnancy and Asthma in Offspring.
N Engl J Med 2017 03 23;376(12):1191.
PMID: 28332384
Assessment of phospholipid synthesis related biomarkers for perinatal asphyxia: a piglet study.
Sci Rep 2017 Jan 10;7():40315. Epub 2017 jan 10
PMID: 28071721
When increased mortality indicates improved care: CDH ECMO registry data.
J Pediatr 2017 Nov;190():4-5.
PMID: 29144268
From design to adoption: generating evidence for new technology designed to address leading global health needs: A comprehensive clinical evidence generation plan for the BD Odon Device™.
BJOG 2017 Sep;124 Suppl 4():7-9.
PMID: 28940872
Development of a reliable analytical method to determine lipid peroxidation biomarkers in newborn plasma samples.
Talanta 2016 Jun 01;153():152-7. Epub 2016 mar 4
PMID: 27130102
Development of a reliable method based on ultra-performance liquid chromatography coupled to tandem mass spectrometry to measure thiol-associated oxidative stress in whole blood samples.
J Pharm Biomed Anal 2016 May 10;123():104-12. Epub 2016 feb 9
PMID: 26895495
Short-term effects of cannabidiol after global hypoxia-ischemia in newborn piglets.
Pediatr Res 2016 Nov;80(5):710-718. Epub 2016 jul 21
PMID: 27441365
The Newborn at the edge of viability.
Acta Paediatr 2016 Nov;105(11):1249-1251.
PMID: 27726194
Physical activity and the risk of gestational diabetes mellitus: a systematic review and dose-response meta-analysis of epidemiological studies.
Eur J Epidemiol 2016 Oct;31(10):967-997. Epub 2016 aug 2
PMID: 27485519
Children's Right to Health: Implications for Decision-Making in Newborn Medical Care.
Pediatrics 2016 Jul;138(1). Epub 2016 jun 3
PMID: 27260696
Challenges, priorities and novel therapies for hypoxemic respiratory failure and pulmonary hypertension in the neonate.
J Perinatol 2016 Jun;36 Suppl 2():S32-6.
PMID: 27225964
The fetal circulation, pathophysiology of hypoxemic respiratory failure and pulmonary hypertension in neonates, and the role of oxygen therapy.
J Perinatol 2016 Jun;36 Suppl 2():S3-S11.
PMID: 27225963
A critical review of the 2015 International Liaison Committee on Resuscitation treatment recommendations for resuscitating the newly born infant.
Acta Paediatr 2016 May;105(5):442-4.
PMID: 27062471
Changes of the plasma metabolome of newly born piglets subjected to postnatal hypoxia and resuscitation with air.
Pediatr Res 2016 08;80(2):284-92. Epub 2016 apr 7
PMID: 27055187
Estimation of time since death by vitreous humor hypoxanthine, potassium, and ambient temperature.
Forensic Sci Int 2016 May;262():160-5. Epub 2016 mar 9
PMID: 26994446
Protein-bound tyrosine oxidation, nitration and chlorination by-products assessed by ultraperformance liquid chromatography coupled to tandem mass spectrometry.
Anal Chim Acta 2016 Mar 24;913():104-10. Epub 2016 feb 3
PMID: 26944994
Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs.
PLoS One 2015;10(10):e0140966. Epub 2015 okt 26
PMID: 26501201
What exactly is myalgic encephalomyelitis?
Tidsskr Nor Laegeforen 2015 Oct 20;135(19):1756-9. Epub 2015 okt 20
PMID: 26486672
Early Upregulation of NLRP3 in the Brain of Neonatal Mice Exposed to Hypoxia-Ischemia: No Early Neuroprotective Effects of NLRP3 Deficiency.
Neonatology 2015;108(3):211-9. Epub 2015 aug 13
PMID: 26279061
Hyperoxia and cerebral vasoconstriction in healthy newborns.
Acta Paediatr 2015 Jul;104(7):645-6.
PMID: 26086478
Delivery room management of term and preterm newly born infants.
Neonatology 2015;107(4):365-71. Epub 2015 jun 5
PMID: 26044106
30 years of surfactant research - from basic science to new clinical treatments for the preterm infant.
Neonatology 2015;107(4):314-6. Epub 2015 jun 5
PMID: 26044097
Resuscitating preterm infants with 100% oxygen is associated with higher oxidative stress than room air.
Acta Paediatr 2015 Aug;104(8):759-65. Epub 2015 jun 19
PMID: 25966608
Meconium aspiration syndrome: possible pathophysiological mechanisms and future potential therapies.
Neonatology 2015;107(3):225-30.
PMID: 25721501
Increased expression of inflammatory genes in the neonatal mouse brain after hyperoxic reoxygenation.
Pediatr Res 2015 Feb;77(2):326-33. Epub 2014 nov 25
PMID: 25423075
Do we have an answer when it comes to providing extremely preterm infants with optimal target oxygen saturation?
Acta Paediatr 2015 Mar;104(3):e130-3. Epub 2015 jan 30
PMID: 25348933
Current concepts of oxygen therapy in neonates.
Indian J Pediatr 2015 Jan;82(1):46-52. Epub 2014 okt 18
PMID: 25326155
New growth charts for newborn babies.
Lancet 2014 Sep 6;384(9946):833-5.
PMID: 25209472
Detection of batch effects in liquid chromatography-mass spectrometry metabolomic data using guided principal component analysis.
Talanta 2014 Dec;130():442-8. Epub 2014 jul 18
PMID: 25159433
Twins should be delivered before 38 weeks of gestation: AGAINST.
BJOG 2014 Sep;121(10):1293.
PMID: 25155320
More about surfactant, oxygen, caffeine and chronic lung disease.
Neonatology 2014;105(4):320-2. Epub 2014 mai 30
PMID: 24931323
Metabolic adaptation and neuroprotection differ in the retina and choroid in a piglet model of acute postnatal hypoxia.
Pediatr Res 2014 Aug;76(2):127-34. Epub 2014 mai 12
PMID: 24819373
Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis.
JAMA 2014 Apr 16;311(15):1536-46.
PMID: 24737366
Systematic review and meta-analysis of optimal initial fraction of oxygen levels in the delivery room at =32 weeks.
Acta Paediatr 2014 Jul;103(7):744-51. Epub 2014 mai 21
PMID: 24716824
Physical activity and the risk of preeclampsia: a systematic review and meta-analysis.
Epidemiology 2014 May;25(3):331-43.
PMID: 24713878
Contrast-enhanced ultrasound identifies reduced overall and regional renal perfusion during global hypoxia in piglets.
Invest Radiol 2014 Aug;49(8):540-6.
PMID: 24637585
CPS position statement for prenatal counselling before a premature birth: Simple rules for complicated decisions.
Paediatr Child Health 2014 Jan;19(1):22-4.
PMID: 24627651
Effects of Natural versus Synthetic Surfactant with SP-B and SP-C Analogs in a Porcine Model of Meconium Aspiration Syndrome.
Neonatology 2014;105(2):128-35. Epub 2013 des 14
PMID: 24356240
Optimal oxygenation of extremely low birth weight infants: a meta-analysis and systematic review of the oxygen saturation target studies.
Neonatology 2014;105(1):55-63. Epub 2013 nov 15
PMID: 24247112
[Oxygen to premature births--a new scandal?].
Tidsskr Nor Laegeforen 2013 Oct 15;133(19):2062-4.
PMID: 24129538
Reliability of pulse oximetry in hypoxic newborn pigs.
J Matern Fetal Neonatal Med 2014 May;27(8):833-8. Epub 2013 okt 11
PMID: 24090354
OHRP and SUPPORT: lessons in balancing safety and improving the way we care for patients.
J Pediatr 2013 Nov;163(5):1495-7. Epub 2013 sep 17
PMID: 24050739
The use of continuous positive airway pressure in preterm babies with respiratory distress syndrome: a report from Baghdad, Iraq.
J Matern Fetal Neonatal Med 2013 Aug 19. Epub 2013 aug 19
PMID: 23885695
Metabolomic Analysis of the Effect of Postnatal Hypoxia on the Retina in a Newly Born Piglet Model.
PLoS One 2013;8(6):e66540. Epub 2013 jun 18
PMID: 23823578
European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants--2013 update.
Neonatology 2013;103(4):353-68. Epub 2013 mai 31
PMID: 23736015
Better neonatal outcomes: oxygen, surfactant and drug delivery. Preface.
Neonatology 2013;103(4):316-9. Epub 2013 mai 31
PMID: 23736008
Association between umbilical cord artery pCO2 and the Apgar score; elevated levels of pCO2 may be beneficial for neonatal vitality after moderate acidemia.
Acta Obstet Gynecol Scand 2013 Jun;92(6):662-70. Epub 2013 mar 29
PMID: 23551012
Hyperoxic resuscitation after hypoxia-ischemia induces cerebral inflammation that is attenuated by tempol in a reporter mouse model with very young mice.
J Perinat Med 2013 May;41(3):251-7.
PMID: 23241583
Perinatal hypoxic- ischemic brain injury: Detection and intervention
- Disputert:
- desember 2017
- Hovedveileder:
- Ola Didrik Saugstad
Newborn resusctiation. An experimental study of inflammatory and hemodynamic responses in newborn pigs
- Disputert:
- desember 2015
- Hovedveileder:
- Ola Didrik Saugstad
- Rønnaug Solberg Medveileder
- Håvard Tetlie Garberg Doktorgradsstipendiat (annen finansiering)
- Marianne Ullestad Huun Doktorgradsstipendiat (annen finansiering)
- Torkil Benterud Doktorgradsstipendiat (annen finansiering)
- Ola Didrik Saugstad Prosjektleder
- Cecilie Revhaug Doktorgradsstipendiat (annen finansiering)
- Håvard Garberg Doktorgradsstipendiat
- Marianne Huun Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport