Proteoglycans are Important Signal Mediators in Myocardial Fibrosis and Heart Failure
- Prosjektnummer
- 2014048
- Ansvarlig person
- Geir Christensen
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 1. Underpinning, 5. Treatment Developement
Nei
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The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling.
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Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease.
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Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in mice.
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Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.
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Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5.
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Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.
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New aspects in myocardial remodeling and dysfunction due to left ventricular pressure overload
- Disputert:
- september 2016
- Hovedveileder:
- Theis Tønnessen
The extracellular matrix in heart failure: Proteoglycans and collagens as regulators of fibrosis and cardiac dysfunction
- Disputert:
- februar 2016
- Hovedveileder:
- Ida Gjervold Lunde
Syndecan-4 in Cardiac Fibroblasts. Role in Regulation of Extracellular Matrix and Myocardial Stiffness.
- Disputert:
- mars 2015
- Hovedveileder:
- Geir Arve Christensen
- Geir Arve Christensen Prosjektleder
- Theis Tønnessen Forskningsgruppeleder
- Ida Gjervold Lunde Forskningsgruppeleder
- Ivar Sjaastad Forskningsgruppeleder
- Kate Louise Møller Herum Postdoktorstipendiat (annen finansiering)
- Kristin V Thunheim Engebretsen Prosjektdeltaker
- Andreas Romaine Doktorgradsstipendiat (finansiert av denne bevilgning)
- Kine Andenæs Doktorgradsstipendiat (finansiert av denne bevilgning)
- Arne Olav Melleby Doktorgradsstipendiat (annen finansiering)
- Lars Gullestad Forskningsgruppeleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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