Assessment of aberrant signaling pathways in B-cell lymphoma - prognostic and therapeutic potential
- Prosjektnummer
- 2014075
- Ansvarlig person
- Erlend B. Smeland
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Blood, Cancer
- Forskningsaktivitet
- 1. Underpinning
NEI
Human Germinal Center B Cells Differ from Naïve and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response.
Cytometry A 2019 Apr;95(4):442-449. Epub 2019 mar 5
PMID: 30838773
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5.
PLoS One 2017;12(5):e0177188. Epub 2017 mai 10
PMID: 28489883 - Inngår i doktorgradsavhandlingen
Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling.
Blood 2017 02 09;129(6):759-770. Epub 2016 des 23
PMID: 28011673
Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations.
Cytometry B Clin Cytom 2017 Jan;92(1):79-87.
PMID: 27933753
Increased expression of CD79B or CD79B Y196 mutated variants found in diffuse large B-cell lymphoma confers higher potential for plasmablast differentiation and BCR signaling
submitted
CD79B is needed for maturation and surface expression of IgM, but is dispensable for B-cell antigen receptor signaling
manuscript not yet submitted
B-cell antigen receptor- and bone morphogenetic protein-induced signalling in normal and malignant B cells
- Disputert:
- desember 2018
- Hovedveileder:
- June Helen Myklebust
- Vera Irene Hilden Prosjektdeltaker
- Sebastien Waelchli Prosjektdeltaker
- Baoyan Bai Prosjektdeltaker
- June Myklebust Hovedveileder
- Erlend B Smeland Prosjektleder
- Kanutte Huse Medveileder
- Lise Kristin Bollum Doktorgradsstipendiat (finansiert av denne bevilgning)
- Arne Kolstad Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport