Precision Oncology in Lung Cancer - a regional project
- Prosjektnummer
- 2014094
- Ansvarlig person
- Odd Terje Brustugun
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
Substantial nation-wide improvement in lung cancer relative survival in Norway from 2000 to 2016.
Lung Cancer 2018 Aug;122():138-145. Epub 2018 jun 6
PMID: 30032822
Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease.
BMC Cancer 2018 Jul 13;18(1):739. Epub 2018 jul 13
PMID: 30005623
Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy.
Adv Radiat Oncol 2018 Apr-Jun;3(2):130-138. Epub 2018 feb 13
PMID: 29904737
Circulating microRNAs associated with prolonged overall survival in lung cancer patients treated with nivolumab.
Acta Oncol 2018 Sep;57(9):1225-1231. Epub 2018 apr 23
PMID: 29683761
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.
Nat Commun 2018 03 13;9(1):1048. Epub 2018 mar 13
PMID: 29535388
Management of Progressive Pulmonary Nodules Found during and outside of CT Lung Cancer Screening Studies.
J Thorac Oncol 2017 Dec;12(12):1755-1765. Epub 2017 sep 27
PMID: 28962947
NSCLC depend upon YAP expression and nuclear localization after acquiring resistance to EGFR inhibitors.
Genes Cancer 2017 Mar;8(3-4):497-504.
PMID: 28680534
Implementation of lung cancer CT screening in the Nordic countries.
Acta Oncol 2017 Oct;56(10):1249-1257. Epub 2017 jun 1
PMID: 28571524
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival.
Int J Cancer 2017 07 01;141(1):184-190. Epub 2017 apr 21
PMID: 28387924
PIK3CA mutations as prognostic factor in squamous cell lung carcinoma.
Lung Cancer 2017 01;103():52-57. Epub 2016 nov 28
PMID: 28024696
Real-world data on nivolumab treatment of non-small cell lung cancer.
Acta Oncol 2017 Mar;56(3):438-440. Epub 2016 nov 28
PMID: 27892773
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.
Nat Genet 2017 Jan;49(1):65-74. Epub 2016 nov 21
PMID: 27869826
The Potential of Combined Immunotherapy and Antiangiogenesis for the Synergistic Treatment of Advanced NSCLC.
J Thorac Oncol 2017 02;12(2):194-207. Epub 2016 okt 8
PMID: 27729297
Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease.
Clin Transl Immunology 2016 Nov;5(11):e109. Epub 2016 nov 2
PMID: 27990285
Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer.
Diagn Pathol 2016 Jun 17;11(1):50. Epub 2016 jun 17
PMID: 27316334
TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients.
Front Genet 2016;7():85. Epub 2016 mai 11
PMID: 27242894
A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer.
Oncotarget 2016 Jun 14;7(24):37250-37259.
PMID: 27191990
Rituximab efficiently depletes B cells in lung tumors and normal lung tissue.
F1000Res 2016;5():38. Epub 2016 jan 8
PMID: 27081474
The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma--differences in histological subtypes.
BMC Cancer 2016 Feb 08;16():71. Epub 2016 feb 8
PMID: 26858029
Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis.
Mol Oncol 2016 Feb;10(2):330-43. Epub 2015 nov 6
PMID: 26601720
EGFR mutation testing of lung cancer patients - Experiences from Vestfold Hospital Trust.
Acta Oncol 2016;55(2):149-55. Epub 2015 aug 26
PMID: 26313507
NUT expression in primary lung tumours.
Diagn Pathol 2015;10():156. Epub 2015 sep 5
PMID: 26341600
Comprehensive genomic profiles of small cell lung cancer.
Nature 2015 Aug 6;524(7563):47-53. Epub 2015 jul 13
PMID: 26168399
Hypoxia as a cause of treatment failure in non-small cell carcinoma of the lung.
Semin Radiat Oncol 2015 Apr;25(2):87-92. Epub 2014 nov 29
PMID: 25771412
Stromal CD8+ T-cell Density—A Promising Supplement to TNM Staging in Non-Small Cell Lung Cancer.
Clin Cancer Res 2015 Jun 1;21(11):2635-43. Epub 2015 feb 13
PMID: 25680376
Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data.
Genome Biol 2015;16():7. Epub 2015 jan 5
PMID: 25650807
Years of life lost as a measure of cancer burden on a national level.
Br J Cancer 2014 Aug 26;111(5):1014-20. Epub 2014 jul 1
PMID: 24983370
[Time counts!].
Tidsskr Nor Laegeforen 2014 May 13;134(9):915. Epub 2014 mai 13
PMID: 24828708
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.
Nat Commun 2014;5():3518. Epub 2014 mar 27
PMID: 24670920
Unique microRNA-profiles in EGFR-mutated lung adenocarcinomas.
Int J Cancer 2014 Oct 15;135(8):1812-21. Epub 2014 mar 14
PMID: 24599520
BRAF-mutations in non-small cell lung cancer.
Lung Cancer 2014 Apr;84(1):36-8. Epub 2014 feb 3
PMID: 24552757
Human papilloma virus detection and typing in 334 lung cancer patients.
Acta Oncol 2014 Jul;53(7):952-7. Epub 2014 jan 21
PMID: 24446743
Rapid reduction in the incidence of cancer of unknown primary. A population-based study.
Acta Oncol 2014 Jan;53(1):134-7. Epub 2013 apr 4
PMID: 23550957
Prognostic, diagnostic and predictive value of various proteins and mutations in lung carcinomas
- Disputert:
- desember 2018
- Hovedveileder:
- Odd Terje Brustugun
Epidemiological and molecular characteristics of lung cancer. Population-based and molecular studies
- Disputert:
- september 2016
- Hovedveileder:
- Odd Terje Brustugun
- Cecilie Bråthen Brukerrepresentant
- Ingjerd Solvoll Prosjektdeltaker
- Marius Lund-Iversen Doktorgradsstipendiat (finansiert av denne bevilgning)
- Odd Terje Brustugun Prosjektleder
- Lilach Kleinberg Postdoktorstipendiat (finansiert av denne bevilgning)
- Marc Kevin Mcgowan Doktorgradsstipendiat (finansiert av denne bevilgning)
- Åslaug Helland Prosjektdeltaker
- Anne Pernille Dyrbekk Prosjektdeltaker
- Inger Johanne Eide Prosjektdeltaker
- Camilla Maria Troøien Sagerup Doktorgradsstipendiat (annen finansiering)
- Inger Johanne Zwicky Eide Prosjektdeltaker
- Marc McGowan Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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