Novel and known DNA and RNA modifications - role in disease
- Prosjektnummer
- 2015027
- Ansvarlig person
- Arne Klungland
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Cancer, Neurological, Reproductive Health and Childbirth, Generic Health Relevance
- Forskningsaktivitet
- 1. Underpinning, 5. Treatment Developement
ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage.
Cell Death Dis 2017 Jul 20;8(7):e2947. Epub 2017 jul 20
PMID: 28726787
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.
Cell Discov 2017;3():17013. Epub 2017 mai 9
PMID: 28529766
Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy.
PLoS One 2017;12(3):e0168182. Epub 2017 mar 13
PMID: 28288181
Base-excision repair and beyond --A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015.
Sci China Life Sci 2016 Jan;59(1):89-92. Epub 2015 des 16
PMID: 26676642
Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015.
Genomics Proteomics Bioinformatics 2016 Jun;14(3):122-5. Epub 2015 des 12
PMID: 26689322
Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells.
Cell Physiol Biochem 2016;38(1):173-84. Epub 2016 jan 15
PMID: 26765775
Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations.
Fertil Steril 2016 May;105(5):1170-1179.e5. Epub 2016 jan 25
PMID: 26820768
ALKBHs-facilitated RNA modifications and de-modifications.
DNA Repair (Amst) 2016 Aug;44():87-91. Epub 2016 mai 17
PMID: 27237585
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.
Epigenetics Chromatin 2016;9():21. Epub 2016 mai 31
PMID: 27252783
Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice.
PLoS Curr 2016 Jul 05;8(). Epub 2016 jul 5
PMID: 27540492
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain.
Neurobiol Aging 2016 Dec;48():34-47. Epub 2016 aug 18
PMID: 27639119
Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.
Mol Cell Neurosci 2016 Dec;77():47-52. Epub 2016 okt 14
PMID: 27751903
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine.
Free Radic Biol Med 2017 Jun;107():62-68. Epub 2016 nov 24
PMID: 27890639
Reversible RNA modifications in meiosis and pluripotency.
Nat Methods 2016 Dec 29;14(1):18-22.
PMID: 28032624
ALKBH1-Mediated tRNA Demethylation Regulates Translation.
Cell 2016 Oct 20;167(3):816-828.e16. Epub 2016 okt 13
PMID: 27745969
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.
Nature 2016 Sep 22;537(7621):548-552. Epub 2016 sep 14
PMID: 27626377
Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.
PLoS One 2015;10(11):e0141472. Epub 2015 nov 6
PMID: 26544960
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes Dev 2015 Oct 1;29(19):2037-53. Epub 2015 sep 24
PMID: 26404942
Non-homologous functions of the AlkB homologs.
J Mol Cell Biol 2015 Dec;7(6):494-504. Epub 2015 mai 23
PMID: 26003568
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes.
Genome Res 2015 Jun;25(6):897-906. Epub 2015 mar 23
PMID: 25800674
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell Rep 2015 Dec 29;13(12):2671-8. Epub 2015 des 17
PMID: 26711335
The involvement of 5-Hydroxymethylcytosine in Two DNA Metabolism Pathways:Transcription and double stranded DNA Breaks
- Disputert:
- desember 2015
- Hovedveileder:
- Arne Klungland
DNA Base Excision Repair: Mutation Induction and Novel Functions
- Disputert:
- juni 2015
- Hovedveileder:
- Svein Bjelland
- Miaomiao Li Doktorgradsstipendiat (finansiert av denne bevilgning)
- Sonia Pena Perez Forskningsgruppeleder
- Arne Klungland Prosjektleder
- Gunn Annette Hildrestrand Prosjektdeltaker
- John Arne Dahl Prosjektdeltaker
- Endalkachew Ashenafi Alemu Prosjektdeltaker
- Miriam Landfors Doktorgradsstipendiat (finansiert av denne bevilgning)
- Gareth Wyn Griffiths Forsker (annen finansiering)
- Knut Tomas Dalen Prosjektdeltaker
- Gareth Griffiths Prosjektdeltaker
- Håvard Aanes Postdoktorstipendiat (annen finansiering)
- Dominique Ober Doktorgradsstipendiat
- Xu Zhao Postdoktorstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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