A Regional Research Network on Breast Cancer for Better Diagnosis and Treatment
- Prosjektnummer
- 2015085
- Ansvarlig person
- Kristine Kleivi Sahlberg
- Institusjon
- Vestre Viken HF
- Prosjektkategori
- Regionalt nettverk
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis, 6. Treatment Evaluation
Regionalt nettverk for brystkreftforskning har arrangert en årlig 2-3 dagers workshop for nettverkmedlemmer. Internasjonale foredragsholdere er invitert, i tillegg har nettverksmedlemmer presentert sine prosjekter med diskusjon om samarbeid mellom nettverksmedlemmer. Brukermedvirkere har deltatt på workshop. Nettverket har lagt tilrette for samarbeidsprosjekter mellom nettverksmedlemmer, men også tilrettelagt for nasjonalt og internasjonalt samarbeid. Samarbeidsprosjekter og nasjonale prosjekter har fått økonomisk støtte til oppstart av nettverket. Gruppelederene i nettverket har hatt ca 6 møter årlig hvor nettverksstrategi og samarbeid har blitt diskutert. Det er et stort fokus på ressursutnyttelse , deling av forskningsmateriale, metoder og kompetanse på disse møtene. Nettverket har opprettet en populærvitenskaplig nettside på norsk (www.brystkreftforskning.no) og en engelskspråklig forsknings faglig nettside (www.breastcancerresearch.no) hvor informasjon om nettverket og kliniske studier i nettverket blir presentert. Nyheter fra nettverket om konferansedeltakelse, artikler som publiseres med mer presenteres også på nettsidene. I tillegg har nettverket siste året opprettet en facebook profil hvor nyheter om nettverket og brystkreftforskning blir presentert. Brystkreftforeningen er samarbeidspartnere i nettverket, og det er jevnlig møter og dialog med brukerene. Kontakten med Brystkreftforeningen gjør det enklere for de enkelte forskningsprosjektene i nettverket å involvere brukere.
Our genes, our selves: hereditary breast cancer and biological citizenship in Norway.
Med Health Care Philos 2017 Mar;20(1):89-103.
PMID: 27709396
TP53 Mutations in Breast and Ovarian Cancer.
Cold Spring Harb Perspect Med 2017 Jan 03;7(1). Epub 2017 jan 3
PMID: 27815305
DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival.
Oncotarget 2017 Jan 03;8(1):1074-1082.
PMID: 27911866
Assessment of TP53 Polymorphisms and MDM2 SNP309 in Premenopausal Breast Cancer Risk.
Hum Mutat 2017 Mar;38(3):265-268. Epub 2017 jan 23
PMID: 27957778
Fatigue During and After Breast Cancer Therapy-A Prospective Study.
J Pain Symptom Manage 2017 Mar;53(3):551-560. Epub 2016 des 29
PMID: 28042070
Prognostic significance of S100A4-expression and subcellular localization in early-stage breast cancer.
Breast Cancer Res Treat 2017 02;162(1):127-137. Epub 2017 jan 5
PMID: 28058579
Interrogating open issues in cancer precision medicine with patient-derived xenografts.
Nat Rev Cancer 2017 04;17(4):254-268. Epub 2017 jan 20
PMID: 28104906
The Antigenicity of the Tumor Cell - Context Matters.
N Engl J Med 2017 02 02;376(5):491-493.
PMID: 28146670
Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells.
Sci Rep 2017 Mar 08;7():43984. Epub 2017 mar 8
PMID: 28272508
Metabolic Response to Everolimus in Patient-Derived Triple-Negative Breast Cancer Xenografts.
J Proteome Res 2017 May 05;16(5):1868-1879. Epub 2017 apr 3
PMID: 28290700
Apolipoprotein D expression does not predict breast cancer recurrence among tamoxifen-treated patients.
PLoS One 2017;12(3):e0171453. Epub 2017 mar 16
PMID: 28301514
Metabolic re-wiring of isogenic breast epithelial cell lines following epithelial to mesenchymal transition.
Cancer Lett 2017 Jun 28;396():117-129. Epub 2017 mar 18
PMID: 28323032
Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome.
Breast Cancer Res 2017 Mar 29;19(1):44. Epub 2017 mar 29
PMID: 28356166
Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response.
Breast Cancer (Dove Med Press) 2017;9():185-198. Epub 2017 mar 21
PMID: 28356768
The Longitudinal Transcriptional Response to Neoadjuvant Chemotherapy with and without Bevacizumab in Breast Cancer.
Clin Cancer Res 2017 Aug 15;23(16):4662-4670. Epub 2017 mai 9
PMID: 28487444
Inhibition of PTP1B disrupts cell-cell adhesion and induces anoikis in breast epithelial cells.
Cell Death Dis 2017 May 11;8(5):e2769. Epub 2017 mai 11
PMID: 28492548
Metabolic Portraits of Breast Cancer by HR MAS MR Spectroscopy of Intact Tissue Samples.
Metabolites 2017 May 16;7(2). Epub 2017 mai 16
PMID: 28509845
Current guidelines for BRCA testing of breast cancer patients are insufficient to detect all mutation carriers.
BMC Cancer 2017 Jun 21;17(1):438. Epub 2017 jun 21
PMID: 28637432
Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition.
Cancer Discov 2017 10;7(10):1098-1115. Epub 2017 jun 26
PMID: 28652380
Better survival after breast-conserving therapy compared to mastectomy when axillary node status is positive in early-stage breast cancer: a registry-based follow-up study of 6387 Norwegian women participating in screening, primarily operated between 1998 and 2009.
World J Surg Oncol 2017 Jul 03;15(1):118. Epub 2017 jul 3
PMID: 28673296
Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal Carcinoma.
Sci Rep 2017 Jul 17;7(1):5568. Epub 2017 jul 17
PMID: 28717182
Novel immunohistochemistry-based signatures to predict metastatic site of triple-negative breast cancers.
Br J Cancer 2017 Sep 05;117(6):826-834. Epub 2017 jul 18
PMID: 28720841
Breast Cancer Molecular Stratification: From Intrinsic Subtypes to Integrative Clusters.
Am J Pathol 2017 Oct;187(10):2152-2162. Epub 2017 jul 19
PMID: 28733194
A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7.
Thromb Res 2017 Sep;157():111-116. Epub 2017 jul 14
PMID: 28734156
Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate.
ESMO Open 2017;2(2):e000158. Epub 2017 mai 2
PMID: 28761742
CYP2C19*2 and CYP2C19*17 variants and effect of tamoxifen on breast cancer recurrence: Analysis of the International Tamoxifen Pharmacogenomics Consortium dataset.
Sci Rep 2017 Aug 10;7(1):7727. Epub 2017 aug 10
PMID: 28798474
Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case-Control Study from the Norwegian Breast Cancer Screening Program.
Cancer Epidemiol Biomarkers Prev 2017 Dec;26(12):1736-1744. Epub 2017 sep 6
PMID: 28877889
Erratum: Inflammation of mammary adipose tissue occurs in overweight and obese patients exhibiting early-stage breast cancer.
NPJ Breast Cancer 2017;3():35. Epub 2017 sep 5
PMID: 28884144
Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity.
Oncotarget 2017 Aug 22;8(34):57121-57133. Epub 2017 jul 7
PMID: 28915659
Interactions between the tumor and the blood systemic response of breast cancer patients.
PLoS Comput Biol 2017 Sep;13(9):e1005680. Epub 2017 sep 28
PMID: 28957325
Support vector machine for breast cancer classification using diffusion-weighted MRI histogram features: Preliminary study.
J Magn Reson Imaging 2017 Oct 16. Epub 2017 okt 16
PMID: 29044896
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.
Nat Commun 2017 Oct 31;8(1):1221. Epub 2017 okt 31
PMID: 29089486
Relative enhanced diffusivity: noise sensitivity, protocol optimization, and the relation to intravoxel incoherent motion.
MAGMA 2017 Nov 06. Epub 2017 nov 6
PMID: 29110241
DNA methylation at enhancers identifies distinct breast cancer lineages.
Nat Commun 2017 Nov 09;8(1):1379. Epub 2017 nov 9
PMID: 29123100
Prognostic value of PAM50 and risk of recurrence score in patients with early-stage breast cancer with long-term follow-up.
Breast Cancer Res 2017 Nov 14;19(1):120. Epub 2017 nov 14
PMID: 29137653
Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients.
Breast Cancer Res 2017 Nov 28;19(1):125. Epub 2017 nov 28
PMID: 29183390
PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1.
Oncotarget 2017 Nov 28;8(61):102769-102782. Epub 2017 okt 12
PMID: 29262523
Serum N-glycan analysis in breast cancer patients--Relation to tumour biology and clinical outcome.
Mol Oncol 2016 Jan;10(1):59-72. Epub 2015 aug 19
PMID: 26321095
Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors.
Oncotarget 2016 Feb 09;7(6):6891-901.
PMID: 26771843
Gene expression analysis supports tumor threshold over 2.0 cm for T-category breast cancer.
EURASIP J Bioinform Syst Biol 2016 Dec;2016(1):6. Epub 2016 feb 8
PMID: 26900390
No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.
J Med Genet 2016 May;53(5):298-309. Epub 2016 feb 26
PMID: 26921362
Anti-vascular effects of the cytosolic phospholipase A2 inhibitor AVX235 in a patient-derived basal-like breast cancer model.
BMC Cancer 2016 Mar 07;16():191. Epub 2016 mar 7
PMID: 26951085
GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer.
BMC Cancer 2016 Mar 16;16():225. Epub 2016 mar 16
PMID: 26984265
Subtype-specific micro-RNA expression signatures in breast cancer progression.
Int J Cancer 2016 Sep 01;139(5):1117-28. Epub 2016 mai 9
PMID: 27082076
Landscape of somatic mutations in 560 breast cancer whole-genome sequences.
Nature 2016 06 02;534(7605):47-54.
PMID: 27135926
Women at high risk of breast cancer: Molecular characteristics, clinical presentation and management.
Breast 2016 Aug;28():136-44. Epub 2016 jun 16
PMID: 27318168
Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes.
Cancer Metab 2016;4():12. Epub 2016 jun 27
PMID: 27350877
Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer.
Cell Rep 2016 Jul 26;16(4):1166-79. Epub 2016 jul 7
PMID: 27396337
Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients.
Cancer Res 2016 Sep 15;76(18):5326-36. Epub 2016 jul 12
PMID: 27406829
LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer.
EMBO Mol Med 2016 Sep 01;8(9):1052-64. Epub 2016 sep 1
PMID: 27485121
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer.
Cell Rep 2016 Aug 16;16(7):2032-46. Epub 2016 aug 4
PMID: 27498871
Determinants of acquired activated protein C resistance and D-dimer in breast cancer.
Thromb Res 2016 Sep;145():78-83. Epub 2016 aug 3
PMID: 27505249
Tumour hypoxia causes DNA hypermethylation by reducing TET activity.
Nature 2016 Sep 01;537(7618):63-68. Epub 2016 aug 17
PMID: 27533040
Dynamic 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Positron Emission Tomography for Chemotherapy Response Monitoring of Breast Cancer Xenografts.
Mol Imaging Biol 2016 Aug 19. Epub 2016 aug 19
PMID: 27541026
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
Sci Rep 2016 Sep 07;6():32512. Epub 2016 sep 7
PMID: 27600471
Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
Am J Hum Genet 2016 Oct 06;99(4):903-911. Epub 2016 sep 15
PMID: 27640304
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration.
Nat Commun 2016 Sep 26;7():12910. Epub 2016 sep 26
PMID: 27666519
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Oncotarget 2016 Dec 06;7(49):80140-80163.
PMID: 27792995
rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk.
Sci Rep 2016 Nov 15;6():36874. Epub 2016 nov 15
PMID: 27845421
A systematic comparison of copy number alterations in four types of female cancer.
BMC Cancer 2016 Nov 22;16(1):913. Epub 2016 nov 22
PMID: 27876019
Anti-angiogenic therapy affects the relationship between tumor vascular structure and function: A correlation study between micro-computed tomography angiography and dynamic contrast enhanced MRI.
Magn Reson Med 2017 Oct;78(4):1513-1522. Epub 2016 nov 25
PMID: 27888545
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing.
Genome Biol 2016 Dec 09;17(1):250. Epub 2016 des 9
PMID: 27931250
Cytokine profiling of tumor interstitial fluid of the breast and its relationship with lymphocyte infiltration and clinicopathological characteristics.
Oncoimmunology 2016;5(12):e1248015. Epub 2016 okt 24
PMID: 28123884
Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer.
J Thromb Haemost 2016 Feb;14(2):387-96. Epub 2016 jan 30
PMID: 26598923
A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients.
Clin Cancer Res 2015 Mar 1;21(5):1207-14. Epub 2014 des 29
PMID: 25547678
Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer.
Genome Med 2015;7(1):21. Epub 2015 feb 2
PMID: 25873999
Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF.
Breast Cancer Res 2015;17():44. Epub 2015 mar 26
PMID: 25882602
The Sub-Cellular Localization of WRAP53 Has Prognostic Impact in Breast Cancer.
PLoS One 2015;10(10):e0139965. Epub 2015 okt 13
PMID: 26460974
- Tone Frost Bathen Forskningsgruppeleder
- Ole Christian Lingjærde Forskningsgruppeleder
- Bjørn Naume Forskningsgruppeleder
- Gunhild Mælandsmo Forskningsgruppeleder
- Håvard Søiland Forsker (annen finansiering)
- Emiel Janssen Forskningsgruppeleder
- Vessela N. Kristensen Forskningsgruppeleder
- Anne-Lise Børresen-Dale Forsker (annen finansiering)
- Rolf Kåresen Forsker (annen finansiering)
- Therese Sørlie Forsker (annen finansiering)
- Hege Elisabeth Giercksky Russnes Forskningsgruppeleder
- Kristine Kleivi Sahlberg Prosjektleder
- Olaf Johan Hartmann-Johnsen Forskningsgruppeleder
- Ellen Schlichting Forskningsgruppeleder
- Britt Fritzman Forskningsgruppeleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport