Transgenic animals and phenomics
- Prosjektnummer
- 2015094
- Ansvarlig person
- Arne Klungland
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Regional teknologisk kjernefasilitet
- Helsekategori
- Cancer, Cardiovascular, Inflammatory and Immune System, Reproductive Health and Childbirth, Generic Health Relevance
- Forskningsaktivitet
- 1. Underpinning, 7. Disease Management
Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases.
Cell Rep Med 2023 Oct 17;4(10):101211. Epub 2023 okt 4
PMID: 37797615
Single-cell m
Nat Biotechnol 2023 Jun 22. Epub 2023 jun 22
PMID: 37349523
The RNA m
Nat Struct Mol Biol 2023 May;30(5):703. Epub 2023 apr 20
PMID: 37081317
Altered hepatic lipid droplet morphology and lipid metabolism in fasted Plin2-null mice.
J Lipid Res 2023 Dec;64(12):100461. Epub 2023 okt 14
PMID: 37844775
Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue.
Int J Mol Sci 2023 Apr 07;24(8). Epub 2023 apr 7
PMID: 37108048
Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema.
Glia 2023 Nov;71(11):2559. Epub 2023 jul 13
PMID: 37439315
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment.
Genome Biol 2023 Sep 29;24(1):216. Epub 2023 sep 29
PMID: 37773136
Consumption of salmon fishmeal increases hepatic cholesterol content in obese C57BL/6 J mice.
Eur J Nutr 2022 Dec;61(8):4027. Epub 2022 jul 5
PMID: 35788891
Postprandial Effects of Salmon Fishmeal and Whey on Metabolic Markers in Serum and Gene Expression in Liver Cells.
Nutrients 2022 Apr 12;14(8). Epub 2022 apr 12
PMID: 35458155
Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis.
Front Immunol 2022;13():870811. Epub 2022 apr 1
PMID: 35432387
NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length.
Biochem Biophys Rep 2022 Mar;29():101211. Epub 2022 jan 18
PMID: 35079641
Serglycin Is Involved in Adipose Tissue Inflammation in Obesity.
J Immunol 2022 Jan 01;208(1):121. Epub 2021 des 6
PMID: 34872979
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease.
Free Radic Biol Med 2022 Nov 20;193(Pt 2):685. Epub 2022 nov 14
PMID: 36395955
ALKBH5 regulates somatic cell reprogramming in a phase-specific manner.
J Cell Sci 2022 Jun 01;135(11). Epub 2022 jun 10
PMID: 35552718
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.
Commun Biol 2021 12 02;4(1):1354. Epub 2021 des 2
PMID: 34857879
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.
Nat Cell Biol 2021 07;23(7):684-691. Epub 2021 jul 12
PMID: 34253897
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons.
iScience 2021 Dec 17;24(12):103470. Epub 2021 nov 18
PMID: 34988395
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype.
Sci Rep 2021 10 05;11(1):19749. Epub 2021 okt 5
PMID: 34611194
Regulates Atherosclerosis Through C-C Motif Chemokine Ligand 2-Mediated Monocyte Infiltration.
J Am Heart Assoc 2021 07 20;10(14):e020656. Epub 2021 jul 14
PMID: 34259011
Isolated Plin5-deficient cardiomyocytes store less lipid droplets than normal, but without increased sensitivity to hypoxia.
Biochim Biophys Acta Mol Cell Biol Lipids 2021 04;1866(4):158873. Epub 2020 des 26
PMID: 33373698
Plin2 deletion increases cholesteryl ester lipid droplet content and disturbs cholesterol balance in adrenal cortex.
J Lipid Res 2021;62():100048. Epub 2021 feb 11
PMID: 33582145
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction.
JACC Basic Transl Sci 2020 Dec;5(12):1210-1224. Epub 2020 des 9
PMID: 33426377
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.
Free Radic Biol Med 2020 05 20;152():348-354. Epub 2020 apr 4
PMID: 32259578
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma.
Nucleic Acids Res 2020 05 07;48(8):4463-4479.
PMID: 32083667
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation.
Cell Rep 2020 03 24;30(12):4165-4178.e7.
PMID: 32209476
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone.
Mol Neurobiol 2020 Feb;57(2):997-1008. Epub 2019 okt 25
PMID: 31654318
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes.
Nat Cell Biol 2020 04;22(4):380-388. Epub 2020 mar 30
PMID: 32231309
N
Nat Genet 2020 01;52(1):48-55. Epub 2019 des 16
PMID: 31844323
B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2.
J Exp Med 2020 02 03;217(2).
PMID: 31727780
Moderate Loss of the Extracellular Matrix Proteoglycan Lumican Attenuates Cardiac Fibrosis in Mice Subjected to Pressure Overload.
Cardiology 2020;145(3):187-198. Epub 2020 jan 22
PMID: 31968347
Blood lactate dynamics in awake and anaesthetized mice after intraperitoneal and subcutaneous injections of lactate-sex matters.
PeerJ 2020;8():e8328. Epub 2020 jan 6
PMID: 31934509
5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication.
Sci Rep 2019 Jul 30;9(1):11065. Epub 2019 jul 30
PMID: 31363131
Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy.
Neonatology 2019;115(4):355-362. Epub 2019 mar 25
PMID: 30909283
The DNA modification N6-methyl-2'-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction.
Nat Neurosci 2019 04;22(4):534-544. Epub 2019 feb 18
PMID: 30778148
Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression.
Glia 2019 06;67(6):1113-1121. Epub 2019 feb 21
PMID: 30791140
Non-invasive MRI of brain clearance pathways using multiple echo time arterial spin labelling: an aquaporin-4 study.
Neuroimage 2019 03;188():515-523. Epub 2018 des 15
PMID: 30557661
Omega-3 fatty acids regulate plasticity in distinct hippocampal glutamatergic synapses.
Eur J Neurosci 2019 Jan;49(1):40-50. Epub 2018 nov 19
PMID: 30367533
The cardiac syndecan-4 interactome reveals a role for syndecan-4 in nuclear translocation of muscle LIM protein (MLP).
J Biol Chem 2019 05 31;294(22):8717-8731. Epub 2019 apr 9
PMID: 30967474
Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart.
Sci Rep 2019 May 06;9(1):6909. Epub 2019 mai 6
PMID: 31061399
The extracellular matrix proteoglycan lumican improves survival and counteracts cardiac dilatation and failure in mice subjected to pressure overload.
Sci Rep 2019 Jun 24;9(1):9206. Epub 2019 jun 24
PMID: 31235849
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
Nat Immunol 2019 12;20(12):1644-1655. Epub 2019 okt 21
PMID: 31636468
Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus.
Glia 2019 01;67(1):91-100. Epub 2018 okt 10
PMID: 30306658
The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity.
Cereb Cortex 2019 Dec 17;29(12):5166-5179.
PMID: 31050701
Differential m
Mol Cell 2018 Sep 20;71(6):973-985.e5. Epub 2018 sep 6
PMID: 30197295
ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells.
Proc Natl Acad Sci U S A 2018 01 09;115(2):E325-E333. Epub 2017 des 26
PMID: 29279410
The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling.
PLoS One 2018;13(7):e0201422. Epub 2018 jul 27
PMID: 30052659
Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP).
Biochim Biophys Acta Mol Basis Dis 2018 Oct;1864(10):3397-3406. Epub 2018 aug 1
PMID: 30076961
Deficiency Stimulates Thermogenic Beige Adipocytes Through
Diabetes 2018 05;67(5):791-804. Epub 2018 feb 13
PMID: 29440067
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA.
Mitochondrion 2018 05;40():16-28. Epub 2017 sep 8
PMID: 28893634
Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation.
J Perinat Med 2018 Dec 19;47(1):114-124.
PMID: 30020889
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis.
DNA Repair (Amst) 2018 01;61():56-62. Epub 2017 nov 28
PMID: 29207315
Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease.
PLoS One 2018;13(3):e0194896. Epub 2018 mar 22
PMID: 29566083
RNA m
Genome Biol 2018 05 31;19(1):68. Epub 2018 mai 31
PMID: 29855379
Ythdf2-mediated m
Genome Biol 2018 05 31;19(1):69. Epub 2018 mai 31
PMID: 29855337
A Positively Charged Surface Triggers Coagulation Activation Through Factor VII Activating Protease (FSAP).
ACS Appl Mater Interfaces 2017 Nov 22;9(46):40107-40116. Epub 2017 nov 9
PMID: 29091393
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice.
Sci Rep 2017 Jun 29;7(1):4384. Epub 2017 jun 29
PMID: 28663564
Ablation of the Cβ2 subunit of PKA in immune cells leads to increased susceptibility to systemic inflammation in mice.
Eur J Immunol 2017 11;47(11):1880-1889. Epub 2017 sep 14
PMID: 28837222
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell Rep 2017 01 03;18(1):82-92.
PMID: 28052262
Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes.
DNA Repair (Amst) 2017 Oct;58():13-20. Epub 2017 aug 12
PMID: 28843610
ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage.
Cell Death Dis 2017 Jul 20;8(7):e2947. Epub 2017 jul 20
PMID: 28726787
Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation.
J Lipid Res 2017 Nov;58(11):2147-2161. Epub 2017 aug 19
PMID: 28822960
Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.
Int J Biochem Cell Biol 2017 Oct;91(Pt A):9-13. Epub 2017 aug 12
PMID: 28811250
LXRα Regulates Hepatic ChREBPα Activity and Lipogenesis upon Glucose, but Not Fructose Feeding in Mice.
Nutrients 2017 Jun 29;9(7). Epub 2017 jun 29
PMID: 28661453
Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells.
Biochim Biophys Acta 2017 06;1862(6):623-635. Epub 2017 feb 17
PMID: 28219719
Deletion of Aquaporin-4 Curtails Extracellular Glutamate Elevation in Cortical Spreading Depression in Awake Mice.
Cereb Cortex 2017 Jan 01;27(1):24-33.
PMID: 28365776
Human and mouse cortical astrocytes differ in aquaporin-4 polarization toward microvessels.
Glia 2017 Jun;65(6):964-973. Epub 2017 mar 20
PMID: 28317216
Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.
Mucosal Immunol 2017 Dec 20. Epub 2017 des 20
PMID: 29346346
Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.
Mol Cell Neurosci 2016 Dec;77():47-52. Epub 2016 okt 14
PMID: 27751903
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain.
Neurobiol Aging 2016 Dec;48():34-47. Epub 2016 aug 18
PMID: 27639119
Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice.
PLoS Curr 2016 Jul 05;8(). Epub 2016 jul 5
PMID: 27540492
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Sci Rep 2016 Jun 22;6():28337. Epub 2016 jun 22
PMID: 27328939
Perilipin 5 is protective in the ischemic heart.
Int J Cardiol 2016 Sep 15;219():446-54. Epub 2016 jun 16
PMID: 27376234
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell Rep 2015 Dec 29;13(12):2671-8. Epub 2015 des 17
PMID: 26711335
Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.
PLoS One 2015;10(11):e0141472. Epub 2015 nov 6
PMID: 26544960
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes Dev 2015 Oct 1;29(19):2037-53. Epub 2015 sep 24
PMID: 26404942
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure.
Am J Physiol Heart Circ Physiol 2015 Aug 1;309(3):H434-49. Epub 2015 jun 8
PMID: 26055793
Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway.
Sci Rep 2015;5():17409. Epub 2015 nov 30
PMID: 26616534
- Sonia Pena Perez Prosjektdeltaker
- Shaista Khan Prosjektleder
- Ingunn Jermstad Prosjektdeltaker
- Gaute Nesse Prosjektdeltaker
- Knut Tomas Dalen Prosjektleder
- Arne Klungland Prosjektleder
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