National Core Facility for Human Pluripotent Stem Cells
- Prosjektnummer
- 2015102
- Ansvarlig person
- Joel C. Glover
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Regional teknologisk kjernefasilitet
- Helsekategori
- Generic Health Relevance
- Forskningsaktivitet
- 5. Treatment Developement
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia.
Transl Psychiatry 2021 10 29;11(1):554. Epub 2021 okt 29
PMID: 34716291
Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia.
Brain Behav Immun 2021 05;94():235-244. Epub 2021 feb 9
PMID: 33571628
N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation.
Exp Neurol 2021 03;337():113536. Epub 2020 nov 29
PMID: 33264635
Scaffold-Free Engineering of Human Cartilage Implants.
Cartilage 2021 12;13(1_suppl):1237S-1249S. Epub 2021 apr 15
PMID: 33858229
Using iPSC Models to Understand the Role of Estrogen in Neuron-Glia Interactions in Schizophrenia and Bipolar Disorder.
Cells 2021 01 21;10(2). Epub 2021 jan 21
PMID: 33494281
Autophagy modulates cell fate decisions during lineage commitment.
Autophagy 2022 Aug;18(8):1915. Epub 2021 des 19
PMID: 34923909
Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model.
Front Cell Dev Biol 2021;9():744777. Epub 2021 okt 14
PMID: 34722525
Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With
Front Cell Dev Biol 2021;9():737304. Epub 2021 sep 24
PMID: 34631714
Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders.
Mol Psychiatry 2021 Nov;26(11):6789-6805. Epub 2021 jun 1
PMID: 34075196
In vivo Cell Tracking Using Non-invasive Imaging of Iron Oxide-Based Particles with Particular Relevance for Stem Cell-Based Treatments of Neurological and Cardiac Disease.
Mol Imaging Biol 2020 12;22(6):1469-1488.
PMID: 31802361
Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties.
Sci Rep 2019 09 10;9(1):12934. Epub 2019 sep 10
PMID: 31506459
In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress.
Acta Physiol (Oxf) 2020 04;228(4):e13433. Epub 2020 jan 8
PMID: 31872528
Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells.
Sci Rep 2019 Nov 05;9(1):16031. Epub 2019 nov 5
PMID: 31690774
Multi-pathway Protective Effects of MicroRNAs on Human Chondrocytes in an In Vitro Model of Osteoarthritis.
Mol Ther Nucleic Acids 2019 Sep 06;17():776-790. Epub 2019 jul 26
PMID: 31446120
Single-Cell RNA Sequencing of
Cartilage 2021 12;13(2_suppl):774S-784S. Epub 2019 mai 9
PMID: 31072202
Expression of inflammatory cytokines in mesenchymal stromal cells is sensitive to culture conditions and simple cell manipulations.
Exp Cell Res 2019 Jan 01;374(1):122-127. Epub 2018 nov 26
PMID: 30496759
3D bioprinted hydrogel model incorporating β-tricalcium phosphate for calcified cartilage tissue engineering.
Biofabrication 2019 05 03;11(3):035016. Epub 2019 mai 3
PMID: 30943457
Uhrf1 regulates active transcriptional marks at bivalent domains in pluripotent stem cells through Setd1a.
Nat Commun 2018 07 03;9(1):2583. Epub 2018 jul 3
PMID: 29968706
Directed reprogramming of comprehensively characterized dental pulp stem cells extracted from natal tooth.
Sci Rep 2018 Apr 18;8(1):6168. Epub 2018 apr 18
PMID: 29670257
Advances in stem cell therapy for amyotrophic lateral sclerosis.
Expert Opin Biol Ther 2018 08;18(8):865-881.
PMID: 30025485
Dystonia-deafness syndrome caused by ACTB p.Arg183Trp heterozygosity shows striatal dopaminergic dysfunction and response to pallidal stimulation.
J Neurodev Disord 2018 May 22;10(1):17. Epub 2018 mai 22
PMID: 29788902
Rapid Screening of the Endodermal Differentiation Potential of Human Pluripotent Stem Cells.
Curr Protoc Stem Cell Biol 2017 Nov 15;43():1G.7.1-1G.7.23. Epub 2017 nov 15
PMID: 29140570
Development of an inducible platform for intercellular protein delivery.
Int J Pharm 2017 Apr 30;522(1-2):1-10. Epub 2017 feb 28
PMID: 28254654
Low-dose acetaminophen induces early disruption of cell-cell tight junctions in human hepatic cells and mouse liver.
Sci Rep 2017 Jan 30;7():37541. Epub 2017 jan 30
PMID: 28134251
Functional Human Beige Adipocytes From Induced Pluripotent Stem Cells.
Diabetes 2017 06;66(6):1470-1478. Epub 2017 mar 7
PMID: 28270520
Cellular reactions and compensatory tissue re-organization during spontaneous recovery after spinal cord injury in neonatal mice.
Dev Neurobiol 2017 Sep;77(8):928-946. Epub 2017 feb 17
PMID: 28033684
Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo.
Cell Med 2017;9(3):103-116. Epub 2017 apr 14
PMID: 28713640
Modeling psychiatric disorders: from genomic findings to cellular phenotypes.
Mol Psychiatry 2016 Sep;21(9):1167-79. Epub 2016 mai 31
PMID: 27240529
Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines.
Sci Rep 2016 Nov 22;6():37178. Epub 2016 nov 22
PMID: 27872482
Small-Molecule-Directed Hepatocyte-Like Cell Differentiation of Human Pluripotent Stem Cells.
Curr Protoc Stem Cell Biol 2016 Aug 17;38():1G.6.1-1G.6.18. Epub 2016 aug 17
PMID: 27532814
Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly.
Stem Cells Transl Med 2016 Sep;5(9):1171-81. Epub 2016 jul 7
PMID: 27388238
Reversible RNA modifications in meiosis and pluripotency.
Nat Methods 2016 Dec 29;14(1):18-22.
PMID: 28032624
Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells.
Cell Physiol Biochem 2016;38(1):173-84. Epub 2016 jan 15
PMID: 26765775
Small-molecule-driven hepatocyte differentiation of human pluripotent stem cells.
Stem Cell Reports 2015 May 12;4(5):939-52. Epub 2015 apr 30
PMID: 25937370
Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo.
Mol Cancer 2015;14():121. Epub 2015 jun 17
PMID: 26081429
Epigenetic priming of inflammatory response genes by high glucose in adipose progenitor cells.
Biochem Biophys Res Commun 2015 Nov 27;467(4):979-86. Epub 2015 okt 14
PMID: 26462465
Investigation into in vitro hepatocyte models: Method development and applications
- Disputert:
- mars 2016
- Hovedveileder:
- Gareth Sullivan
- Helena Lading Forsker (annen finansiering)
- Elisabeth Dybing Prosjektdeltaker
- Hege Brincker Fjerdingstad Prosjektdeltaker
- Joel Glover Prosjektleder
- Ursula Barbara Braun Prosjektdeltaker
- Kirstin Buchholz Prosjektdeltaker
- Tabea Sinkovic Prosjektdeltaker
- Kirstin Bucholz Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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