Translational studies on lung cancer
- Prosjektnummer
- 2016056
- Ansvarlig person
- Åslaug Helland
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Forskerstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis, 6. Treatment Evaluation
NEI
Nei, bortsett fra mange turer til samarebidende institusjoner
NEI
nei
nei
Nei
EGFR-mutation testing, treatment patterns and clinical outcomes in patients with stage IB-IIIA non-small cell lung cancer in Norway-a nationwide cohort study.
Cancer Treat Res Commun 2023 Dec 28;38():100785. Epub 2023 des 28
PMID: 38190787
Strategies to decrease inequalities in cancer therapeutics, care and prevention: Proceedings on a conference organized by the Pontifical Academy of Sciences and the European Academy of Cancer Sciences, Vatican City, February 23-24, 2023.
Mol Oncol 2023 Dec 22. Epub 2023 des 22
PMID: 38135904
Modified study designs to expand treatment options in personalised oncology: a multistakeholder view.
Eur J Cancer 2023 Nov;194():113278. Epub 2023 aug 4
PMID: 37820553
Initial investigation of using Norwegian health data for the purpose of external comparator arms - an example for non-small cell lung cancer.
Acta Oncol 2023 Dec;62(12):1642. Epub 2023 nov 25
PMID: 37801361
Factors associated with failure to start consolidation durvalumab after definitive chemoradiation for locally advanced NSCLC.
Front Oncol 2023;13():1217424. Epub 2023 jul 5
PMID: 37476372
Tracheal cancer: a rare and deadly but potentially curable disease that also affects younger people.
Eur J Cardiothorac Surg 2023 Jul 03;64(1).
PMID: 37348858
Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial.
Ann Oncol 2023 Jul;34(7):578. Epub 2023 apr 24
PMID: 37100205
A trans-omics assessment of gene-gene interaction in early-stage NSCLC.
Mol Oncol 2023 Jan;17(1):173. Epub 2022 des 5
PMID: 36408734
Associations between patient-reported late effects and systemic cytokines in long-term survivors of head and neck cancer treated with radiotherapy.
J Cancer Surviv 2023 Aug;17(4):1082. Epub 2022 nov 9
PMID: 36350483
Atezolizumab and stereotactic body radiotherapy in patients with advanced non-small cell lung cancer: safety, clinical activity and ctDNA responses-the ComIT-1 trial.
Mol Oncol 2023 Mar;17(3):487. Epub 2022 nov 22
PMID: 36330681
Radiation-induced long-term dysphagia in survivors of head and neck cancer and association with dose-volume parameters.
Radiother Oncol 2023 Dec 05;190():110044. Epub 2023 des 5
PMID: 38061420
2.5D and 3D segmentation of brain metastases with deep learning on multinational MRI data.
Front Neuroinform 2022;16():1056068. Epub 2023 jan 18
PMID: 36743439
Improvements in survival for patients with stage IV adenocarcinoma in the lung, diagnosed between 2010 - 2020 - A population-based registry study from Norway.
Front Oncol 2022;12():1017902. Epub 2022 nov 29
PMID: 36523970
A phase I/II escalation trial design T-RAD: Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT).
Front Oncol 2022;12():1031232. Epub 2022 nov 10
PMID: 36439452
EGFR-mutation testing and TKI treatment patterns in locally advanced and metastatic NSCLC in Norway - A nationwide retrospective cohort study.
Cancer Treat Res Commun 2022;33():100636. Epub 2022 sep 16
PMID: 36155129
Concordance between clinical and pathology TNM-staging in lung cancer.
Lung Cancer 2022 Sep;171():65. Epub 2022 jul 25
PMID: 35926242
Circulating T Cell Activation and Exhaustion Markers Are Associated With Radiation Pneumonitis and Poor Survival in Non-Small-Cell Lung Cancer.
Front Immunol 2022;13():875152. Epub 2022 jul 14
PMID: 35911763
Osimertinib in non-small cell lung cancer with uncommon
Transl Lung Cancer Res 2022 Jun;11(6):953.
PMID: 35832438
Prognostic Significance of the Loss of Heterozygosity of
Front Oncol 2022;12():873532. Epub 2022 apr 29
PMID: 35574381
Serum RNAs can predict lung cancer up to 10 years prior to diagnosis.
Elife 2022 Feb 11;11(). Epub 2022 feb 11
PMID: 35147498
Epigenome-wide three-way interaction study identifies a complex pattern between TRIM27, KIAA0226, and smoking associated with overall survival of early-stage NSCLC.
Mol Oncol 2022 Feb;16(3):717. Epub 2022 jan 7
PMID: 34932879
Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms.
Nat Cancer 2021 Nov;2(11):1224-1242. Epub 2021 nov 22
PMID: 34870237
The Immune Landscape of Human Primary Lung Tumors Is Th2 Skewed.
Front Immunol 2021;12():764596. Epub 2021 nov 18
PMID: 34868011
Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors.
BMC Cancer 2021 Oct 09;21(1):1089. Epub 2021 okt 9
PMID: 34625038
Immunotherapy for malignant pleural mesothelioma.
Tidsskr Nor Laegeforen 2021 09 07;141(). Epub 2021 sep 6
PMID: 34505475
Intracranial effect of osimertinib in relapsed
Acta Oncol 2021 Dec;60(12):1565-1571. Epub 2021 sep 6
PMID: 34486915
MRI pulse sequence integration for deep-learning-based brain metastases segmentation.
Med Phys 2021 Oct;48(10):6020-6035. Epub 2021 aug 18
PMID: 34405896
Dynamic changes in the T cell receptor repertoire during treatment with radiotherapy combined with an immune checkpoint inhibitor.
Mol Oncol 2021 11;15(11):2958-2968. Epub 2021 sep 1
PMID: 34402187
Lung Function After Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer, Changes and Predictive Markers.
Front Oncol 2021;11():674731. Epub 2021 mai 24
PMID: 34109123
NIPU: a randomised, open-label, phase II study evaluating nivolumab and ipilimumab combined with UV1 vaccination as second line treatment in patients with malignant mesothelioma.
J Transl Med 2021 05 31;19(1):232. Epub 2021 mai 31
PMID: 34059094
Real-world treatment outcomes with brigatinib in patients with pretreated ALK+ metastatic non-small cell lung cancer.
Lung Cancer 2021 07;157():9-16. Epub 2021 mai 24
PMID: 34051652
Age-related treatment patterns for stage I NSCLC in three European countries.
J Geriatr Oncol 2021 11;12(8):1214-1219. Epub 2021 mai 14
PMID: 33994330
COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway.
Front Oncol 2021;11():652535. Epub 2021 mar 25
PMID: 33842366
Rovalpituzumab Tesirine as a Maintenance Therapy After First-Line Platinum-Based Chemotherapy in Patients With Extensive-Stage-SCLC: Results From the Phase 3 MERU Study.
J Thorac Oncol 2021 09;16(9):1570-1581. Epub 2021 apr 3
PMID: 33823285
Handling missing MRI sequences in deep learning segmentation of brain metastases: a multicenter study.
NPJ Digit Med 2021 Feb 22;4(1):33. Epub 2021 feb 22
PMID: 33619361
Immune checkpoint blockade in the treatment of advanced non-small cell lung cancer - predictors of response and impact of previous radiotherapy.
Acta Oncol 2021 Feb;60(2):149-156. Epub 2020 des 24
PMID: 33356733
Epigenetic-smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients.
Mol Oncol 2020 Nov;14(11):2759-2774. Epub 2020 sep 3
PMID: 33448640
Protein Kinase C Isozymes Associated With Relapse Free Survival in Non-Small Cell Lung Cancer Patients.
Front Oncol 2020;10():590755. Epub 2020 nov 25
PMID: 33324562
Responses in the diffusivity and vascular function of the irradiated normal brain are seen up until 18 months following SRS of brain metastases.
Neurooncol Adv 2020 Jan-Dec;2(1):vdaa028. Epub 2020 feb 28
PMID: 32642687
Epigenome-wide gene-age interaction analysis reveals reversed effects of
Aging (Albany NY) 2020 06 08;12(11):10642-10662. Epub 2020 jun 8
PMID: 32511103
Molecular characterisation of TP53 mutated squamous cell carcinomas of the lung to identify putative targets for therapy.
Int J Cancer 2020 Nov 15;147(10):2957-2966. Epub 2020 jun 17
PMID: 32468587
The immune microenvironment in typical carcinoid lung tumour, a brief report of four cases.
Scand J Immunol 2020 Aug;92(2):e12893. Epub 2020 jun 9
PMID: 32433774
Antibody combinations for optimized staining of macrophages in human lung tumours.
Scand J Immunol 2020 Jul;92(1):e12889. Epub 2020 mai 10
PMID: 32299134
Osimertinib in T790M-positive and -negative patients with EGFR-mutated advanced non-small cell lung cancer (the TREM-study).
Lung Cancer 2020 05;143():27-35. Epub 2020 mar 12
PMID: 32200138
Radiotherapy-related lymphopenia in patients with advanced non-small cell lung cancer receiving palliative radiotherapy.
Clin Transl Radiat Oncol 2020 May;22():15-21. Epub 2020 feb 19
PMID: 32181373
Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effects.
Chest 2020 Aug;158(2):808-819. Epub 2020 feb 28
PMID: 32113923
A 10-year prediagnostic follow-up study shows that serum RNA signals are highly dynamic in lung carcinogenesis.
Mol Oncol 2020 02;14(2):235-247. Epub 2020 jan 10
PMID: 31851411
PathTracer: High-sensitivity detection of differential pathway activity in tumours.
Sci Rep 2019 Nov 08;9(1):16332. Epub 2019 nov 8
PMID: 31704995
Identification of microRNAs involved in pathways which characterize the expression subtypes of NSCLC.
Mol Oncol 2019 Dec;13(12):2604-2615. Epub 2019 sep 22
PMID: 31505091
Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma.
Aging (Albany NY) 2019 Aug 21;11(16):6312-6335. Epub 2019 aug 21
PMID: 31434796
Increase in curative treatment and survival of lung cancer in Norway 2001-2016.
Eur J Epidemiol 2019 Oct;34(10):951-955. Epub 2019 jul 16
PMID: 31313073
SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic-smoking interaction analysis.
Mol Oncol 2019 05;13(5):1235-1248. Epub 2019 apr 17
PMID: 30924596
The immune microenvironment in non-small cell lung cancer is predictive of prognosis after surgery.
Mol Oncol 2019 05;13(5):1166-1179. Epub 2019 apr 10
PMID: 30854794
EMT network-based feature selection improves prognosis prediction in lung adenocarcinoma.
PLoS One 2019;14(1):e0204186. Epub 2019 jan 31
PMID: 30703089
EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC.
Epigenetics 2019 Feb;14(2):118-129. Epub 2019 jan 31
PMID: 30665327
Brain metastases with poor vascular function are susceptible to pseudoprogression after stereotactic radiation surgery.
Adv Radiat Oncol 2018 Oct-Dec;3(4):559-567. Epub 2018 mai 17
PMID: 30370356
First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.
N Engl J Med 2018 12 06;379(23):2220-2229. Epub 2018 sep 25
PMID: 30280641
Atezolizumab Treatment Beyond Progression in Advanced NSCLC: Results From the Randomized, Phase III OAK Study.
J Thorac Oncol 2018 Dec;13(12):1906-1918. Epub 2018 sep 11
PMID: 30217492
DNA Methylation of
Cancer Epidemiol Biomarkers Prev 2018 Dec;27(12):1527-1535. Epub 2018 sep 5
PMID: 30185536
Substantial nation-wide improvement in lung cancer relative survival in Norway from 2000 to 2016.
Lung Cancer 2018 Aug;122():138-145. Epub 2018 jun 6
PMID: 30032822
Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease.
BMC Cancer 2018 Jul 13;18(1):739. Epub 2018 jul 13
PMID: 30005623
Mapping Bone Marrow Response in the Vertebral Column by Positron Emission Tomography Following Radiotherapy and Erlotinib Therapy of Lung Cancer.
Mol Imaging Biol 2018 Jun 18. Epub 2018 jun 18
PMID: 29916117
Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy.
Adv Radiat Oncol 2018 Apr-Jun;3(2):130-138. Epub 2018 feb 13
PMID: 29904737
Circulating microRNAs associated with prolonged overall survival in lung cancer patients treated with nivolumab.
Acta Oncol 2018 Sep;57(9):1225-1231. Epub 2018 apr 23
PMID: 29683761
Alectinib versus chemotherapy in crizotinib-pretreated anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer: results from the phase III ALUR study.
Ann Oncol 2018 Jun 01;29(6):1409-1416.
PMID: 29668860
A multi-omic study reveals BTG2 as a reliable prognostic marker for early-stage non-small cell lung cancer.
Mol Oncol 2018 Jun;12(6):913-924. Epub 2018 mai 4
PMID: 29656435
Epigenetic modifications in
Clin Epigenetics 2018;10():41. Epub 2018 apr 2
PMID: 29619118
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.
Nat Commun 2018 03 13;9(1):1048. Epub 2018 mar 13
PMID: 29535388
Dabrafenib plus trametinib in patients with previously untreated BRAFV600E-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial.
Lancet Oncol 2017 Oct;18(10):1307-1316. Epub 2017 sep 11
PMID: 28919011
A new method to assess pulmonary changes using 18F-fluoro-2-deoxyglucose positron emission tomography for lung cancer patients following radiotherapy.
Acta Oncol 2017 Nov;56(11):1597-1603. Epub 2017 aug 29
PMID: 28849707
NSCLC depend upon YAP expression and nuclear localization after acquiring resistance to EGFR inhibitors.
Genes Cancer 2017 Mar;8(3-4):497-504.
PMID: 28680534
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival.
Int J Cancer 2017 07 01;141(1):184-190. Epub 2017 apr 21
PMID: 28387924
PIK3CA mutations as prognostic factor in squamous cell lung carcinoma.
Lung Cancer 2017 01;103():52-57. Epub 2016 nov 28
PMID: 28024696
Real-world data on nivolumab treatment of non-small cell lung cancer.
Acta Oncol 2017 Mar;56(3):438-440. Epub 2016 nov 28
PMID: 27892773
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.
Nat Genet 2017 Jan;49(1):65-74. Epub 2016 nov 21
PMID: 27869826
Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease.
Clin Transl Immunology 2016 Nov;5(11):e109. Epub 2016 nov 2
PMID: 27990285
Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer.
Diagn Pathol 2016 Jun 17;11(1):50. Epub 2016 jun 17
PMID: 27316334
TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients.
Front Genet 2016;7():85. Epub 2016 mai 11
PMID: 27242894
A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer.
Oncotarget 2016 Jun 14;7(24):37250-37259.
PMID: 27191990
Rituximab efficiently depletes B cells in lung tumors and normal lung tissue.
F1000Res 2016;5():38. Epub 2016 jan 8
PMID: 27081474
Pulmonary function and serum biomarkers
- Disputert:
- mai 2023
- Hovedveileder:
- Åslaug helland
The non-small cell lung cancer tumor immune microenvironment: implications for treatment and prognosis
- Disputert:
- november 2021
- Hovedveileder:
- Åslaug Helland
The Immune Microenvironment in Human Lung Cancer and Checkpoint Inhibition
- Disputert:
- desember 2021
- Hovedveileder:
- Alexandre Corthay
Circulating microRNAs; biomarkers for early detection, prediction of therapy response and prognosis in cancer patients.
- Disputert:
- september 2017
- Hovedveileder:
- Åslaug Helland
Circulating microRNAs; biomarkers for early detection, prediction of therapy response and prognosis in cancer patients.
- Disputert:
- oktober 2017
- Hovedveileder:
- Åslaug Helland
- Saima Farooqi Doktorgradsstipendiat (annen finansiering)
- Maria Moksnes Bjaanæs Prosjektdeltaker
- Henrik Horndalsveen Doktorgradsstipendiat (annen finansiering)
- Per Oltuis Brukerrepresentant
- Ingjerd Solvoll Prosjektdeltaker
- Odd Terje Brustugun Prosjektdeltaker
- Ann Rita Halvorsen Postdoktorstipendiat (annen finansiering)
- Åsa Øjlert Doktorgradsstipendiat (annen finansiering)
- Janna Berg Doktorgradsstipendiat (annen finansiering)
- Åslaug Helland Prosjektleder
- Vilde Drageset Haakensen Postdoktorstipendiat (annen finansiering)
- Hanne Astrid Eide Doktorgradsstipendiat (annen finansiering)
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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