Schizophrenia Genetics – identifying variants associated with clozapine toxicity
- Prosjektnummer
- 2016097
- Ansvarlig person
- Espen Molden
- Institusjon
- Diakonhjemmet Sykehus AS
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Mental Health
- Forskningsaktivitet
- 5. Treatment Developement, 7. Disease Management
NEI
NEI
NEI
The Effect of Valproic Acid on Olanzapine Serum Concentration: A Study Including 2791 Patients Treated With Olanzapine Tablets or Long-Acting Injections.
J Clin Psychopharmacol 2019 Nov/Dec;39(6):561-566.
PMID: 31688390
Reduction in N-Desmethylclozapine Level Is Determined by Daily Dose But Not Serum Concentration of Valproic Acid-Indications of a Presystemic Interaction Mechanism.
Ther Drug Monit 2019 08;41(4):503-508.
PMID: 31259880
Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study.
Lancet Psychiatry 2019 May;6(5):418-426. Epub 2019 apr 15
PMID: 31000417
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
Nat Genet 2018 Mar;50(3):381-389. Epub 2018 feb 26
PMID: 29483656
Clinically Relevant Effect of UGT1A4*3 on Lamotrigine Serum Concentration Is Restricted to Postmenopausal Women-A Study Matching Therapeutic Drug Monitoring and Genotype Data From 534 Patients.
Ther Drug Monit 2018 10;40(5):567-571.
PMID: 30086088
Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-Acting Injectable Formulations: An Observational Study Including 8,288 Patients.
J Clin Psychopharmacol 2018 Dec;38(6):570-576.
PMID: 30300295
Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients.
Am J Psychiatry 2018 05 01;175(5):463-470. Epub 2018 jan 12
PMID: 29325448
Correlation Between Serum Concentrations of N-Desmethylclozapine and Granulocyte Levels in Patients with Schizophrenia: A Retrospective Observational Study.
CNS Drugs 2017 Nov;31(11):991-997.
PMID: 28948574
- Marja-Liisa Dahl Prosjektdeltaker
- Erik Eliasson Prosjektdeltaker
- Olav Spigset Prosjektdeltaker
- Srdjan Djurovic Prosjektdeltaker
- Ole Andreas Andreassen Prosjektdeltaker
- Robert Løvsletten Smith Postdoktorstipendiat (finansiert av denne bevilgning)
- Espen Molden Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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