Research Network for Clinical Effectiveness in Gastroenterology
- Prosjektnummer
- 2016110
- Ansvarlig person
- Michael Bretthauer
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Regionalt forskningsnettverk
- Helsekategori
- Oral and Gastrointestinal
- Forskningsaktivitet
- 5. Treatment Developement, 6. Treatment Evaluation
Nettverket har også i sitt 6. år hatt stor aktivitet innefor mange områder og grener. Sammenfatingsvis kan nevnes: 1. EPoS studien: denne studien inkluderer de alle fleste av nettverkets foretak og institusjoner og har nå inkludert omlag 15.000 pasienter. Se mer på eposstudy.org. 2. RapidRecs: dette prosjektet har publisert multiple artikler om kliniske retningslinjer de siste årene i BMJ og andre tidsskrifter. I 2018 har det blitt jobbet mye med nye retningslinjer for koloretkatl screening, der mange av nettverkets medlememr har vært involvert. Arbeidene publiseres ila. våren 2019. 3. Kurs i publisering: også i 2018 har det blitt organisert kurs i publisering, i samarbeid med Tidsskiftet og Annals of Internal Medicine. Et nytt kurs er planlagt i mai 2019. 4. Utvikling av nye studier: a. COLONIZE: etter at nettverket publiserte pilotstudien på fecal mikrobiota behandling i New England Journal i Juni 2018 har nettverket sammen med flere regioner blitt tildelt midler fra KLINBEFORSK for å gjøre COLONIZE hovestudien, som har vært under planlegging i andre halvdel 2018. b. BALANCE studiene som omhandler nye gastroenterologiske metoder for fedmebehandling er startet i 2018 av nettverket. 20 pasienter er til nå inkludert i pilotstudier ved OUS og SiV. 5. NordICC studien går inn i sitt 8. år av oppfølging og nettverket har publisert flere artikler fra studien.
I 2017 har nettverket vært igjen svært aktiv. Hovedprosjektene er som tidligere EPoS og NordICC studiene, samt Gastronet samarbeidet, MAGIC samarbeidet og CRC screening piloten. I tillegg er det to store nye prosjekter som ble påbegynt i 2017; BALLOON og C diff sudiene, hhv. om nye gastroenterologiske metoder som kan erstattet fedmekirurgi, og nye behandlingsmetoder for Clostridium difficile kolitt. Disse prosjektene vil gjennomføres de neste årene. I 2017 har det blitt publisert mer enn 60 fagartikler i vitenskapelige tidsskrifter som er utgått fra nettverket. Nettverket har igjen, som i forutgående år, organisert kurs og konferanser, deriblant Kurs i medisinsk publisering, EPoS møte i Alicante, og flere vitenskapelige møter i Oslo (vår og høst 2017). EPoS studien har nå inkludert mer enn 9.000 pasienter, derav mer enn 2.5000 ved nettverkssykehusene. Studien har, med støtte av nettverket, bidratt med å etablere forskingssykepleiere ved alle deltagende sykehus som ledd i å bygge opp et slagkraftig miljø for videre forskning i regi av nettverket. MAGIC gruppen har i 2017 landet en stor avtale med BMJ om publisering av retningslinjer og systematiske oversikter, og nettverket er i 2017 og 2018 i gang med et stort prosjekt innenfor dette samarbeidet, med tema kolorektal screening.
Performance measures for endoscopic retrograde cholangiopancreatography and endoscopic ultrasound: A European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.
United European Gastroenterol J 2018 Dec;6(10):1448-1460. Epub 2018 okt 19
PMID: 30574315
Time to abandon early detection cancer screening.
Eur J Clin Invest 2019 Mar;49(3):e13062. Epub 2019 jan 4
PMID: 30565674
Long-Term Effectiveness of Sigmoidoscopy Screening in Women and Men.
Ann Intern Med 2018 Nov 06;169(9):663-664.
PMID: 30398636
Performance measures for ERCP and endoscopic ultrasound: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.
Endoscopy 2018 Nov;50(11):1116-1127. Epub 2018 okt 19
PMID: 30340220
When no guideline recommendation is the best recommendation.
Lancet 2018 09 15;392(10151):898-899.
PMID: 30238877
Overdiagnosis in Colorectal Cancer Screening: Time to Acknowledge a Blind Spot.
Gastroenterology 2018 Sep;155(3):592-595. Epub 2018 aug 1
PMID: 30076834
From Colorectal Cancer Screening Guidelines to Headlines: Beware!
Ann Intern Med 2018 Sep 18;169(6):405-406. Epub 2018 jul 10
PMID: 29987330
Polypectomy techniques among gastroenterologists in Norway - a nationwide survey.
Endosc Int Open 2018 Jul;6(7):E812-E820. Epub 2018 jul 4
PMID: 29977999
Fecal Microbiota Transplantation for Primary Clostridium difficile Infection.
N Engl J Med 2018 06 28;378(26):2535-2536. Epub 2018 jun 2
PMID: 29860912
Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men: A Randomized Trial.
Ann Intern Med 2018 Jun 05;168(11):775-782. Epub 2018 apr 24
PMID: 29710125
The IARC Perspective on Colorectal Cancer Screening.
N Engl J Med 2018 May 03;378(18):1734-1740. Epub 2018 mar 26
PMID: 29580179
Endoscopy assistants influence the quality of colonoscopy.
Endoscopy 2018 09;50(9):871-877. Epub 2018 feb 14
PMID: 29444529
Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis.
JAMA 2018 12 18;320(23):2448-2460.
PMID: 30561481
Methods for trustworthy nutritional recommendations NutriRECS (Nutritional Recommendations and accessible Evidence summaries Composed of Systematic reviews): a protocol.
BMC Med Res Methodol 2018 Dec 05;18(1):162. Epub 2018 des 5
PMID: 30518328
Including practical issues and patient perspectives in Rapid Recommendations.
BMJ 2018 Nov 20;363():k4871. Epub 2018 nov 20
PMID: 30459184
A systematic review of trials evaluating success factors of interventions with computerised clinical decision support.
Implement Sci 2018 08 20;13(1):114. Epub 2018 aug 20
PMID: 30126421
Understanding conflicts of interest.
Intensive Care Med 2018 Oct;44(10):1738-1740. Epub 2018 aug 6
PMID: 30083991
The GUIDES checklist: development of a tool to improve the successful use of guideline-based computerised clinical decision support.
Implement Sci 2018 06 25;13(1):86. Epub 2018 jun 25
PMID: 29941007
Nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Cascade Guideline.
Endosc Int Open 2018 Oct;6(10):E1256-E1263. Epub 2018 okt 8
PMID: 30302383
Making Colonoscopy Smarter With Standardized Computer-Aided Diagnosis.
Ann Intern Med 2018 Sep 18;169(6):409-410. Epub 2018 aug 14
PMID: 30105378
How I perform sphincterotomy.
Gastrointest Endosc 2018 08;88(2):207-208. Epub 2018 jun 12
PMID: 29907376
No Superiority of Stents vs Balloon Dilatation for Dominant Strictures in Patients With Primary Sclerosing Cholangitis.
Gastroenterology 2018 09;155(3):752-759.e5. Epub 2018 mai 24
PMID: 29803836
Subtherapeutic concentrations of infliximab and adalimumab are associated with increased disease activity in Crohn's disease.
Therap Adv Gastroenterol 2018;11():1756284818759930. Epub 2018 mar 14
PMID: 29623105
Outcome for biliary atresia patients treated at a low-volume centre.
Scand J Gastroenterol 2018 04;53(4):471-474. Epub 2018 mar 16
PMID: 29546790
Correction: Covered vs. uncovered self-expandable metal stents for malignant distal biliary strictures: a systematic review and meta-analysis.
Endoscopy 2018 06;50(6):C5. Epub 2018 feb 7
PMID: 29415285
Covered vs. uncovered self-expandable metal stents for malignant distal biliary strictures: a systematic review and meta-analysis.
Endoscopy 2018 06;50(6):631-641. Epub 2018 jan 17
PMID: 29342491
Pancreas transplant rejection episodes are not revealed by biopsies of the donor duodenum in a prospective study with paired biopsies.
Am J Transplant 2018 May;18(5):1256-1261. Epub 2018 feb 3
PMID: 29316221
Transcriptional and functional profiling defines human small intestinal macrophage subsets.
J Exp Med 2018 Feb 05;215(2):441-458. Epub 2017 des 22
PMID: 29273642
Priority and prejudice: does low socioeconomic status bias waiting time for endoscopy? A blinded, randomized survey.
Scand J Gastroenterol 2018 05;53(5):621-625. Epub 2017 nov 16
PMID: 29141477
Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials.
BMJ 2017 Sep 20;358():j3887. Epub 2017 sep 20
PMID: 28931508
Tidsskr Nor Laegeforen 2017 Sep 19;137(17). Epub 2017 sep 18
PMID: 28925200
Living systematic reviews: 3. Statistical methods for updating meta-analyses.
J Clin Epidemiol 2017 Nov;91():38-46. Epub 2017 sep 11
PMID: 28912004
Colorectal cancer death after adenoma removal in Scandinavia.
Scand J Gastroenterol 2017 Dec;52(12):1377-1384. Epub 2017 sep 14
PMID: 28906163
Domains associated with successful quality improvement in healthcare - a nationwide case study.
BMC Health Serv Res 2017 Sep 13;17(1):648. Epub 2017 sep 13
PMID: 28903723
Epidemiology and risk factors of colorectal polyps.
Best Pract Res Clin Gastroenterol 2017 Aug;31(4):419-424. Epub 2017 jun 28
PMID: 28842051
Colorectal adenomas, surveillance, and cancer.
Lancet Oncol 2017 Aug;18(8):e427. Epub 2017 jul 26
PMID: 28759374
Lakartidningen 2017 Jul 06;114(). Epub 2017 jul 6
PMID: 28696487
Cecum intubation rate as quality indicator in clinical versus screening colonoscopy.
Endosc Int Open 2017 Jun;5(6):E489-E495. Epub 2017 mai 31
PMID: 28573182
Sigmoidoscopy and faecal occult blood test - a comparative screening trial.
Tidsskr Nor Laegeforen 2017 May;137(10):727-730. Epub 2017 mai 23
PMID: 28551972
Status report from Norway: Implementation of patient involvement in Norwegian health care.
Z Evid Fortbild Qual Gesundhwes 2017 Jun;123-124():75-80. Epub 2017 mai 22
PMID: 28546052
Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) quality improvement initiative.
United European Gastroenterol J 2017 Apr;5(3):309-334. Epub 2017 mar 16
PMID: 28507745
Patient-reported adverse events after colonoscopy in Norway.
Endoscopy 2017 Aug;49(8):745-753. Epub 2017 apr 26
PMID: 28445903
Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline.
J Hepatol 2017 Jun;66(6):1265-1281. Epub 2017 apr 18
PMID: 28427764
Gradual stiffness versus magnetic imaging-guided variable stiffness colonoscopes: A randomized noninferiority trial.
United European Gastroenterol J 2017 Feb;5(1):128-133. Epub 2016 jun 23
PMID: 28405331
RE: Which estimates comprise optimal reporting in systematic reviews?
J Clin Epidemiol 2017 Jan;81():140-141.
PMID: 28215276
Multilayered and digitally structured presentation formats of trustworthy recommendations: a combined survey and randomised trial.
BMJ Open 2017 02 10;7(2):e011569. Epub 2017 feb 10
PMID: 28188149
Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials.
BMJ 2017 Jan 13;356():i6673. Epub 2017 jan 13
PMID: 28087510
Are rapidly growing cancers more lethal?
Eur J Cancer 2017 02;72():210-214. Epub 2016 des 30
PMID: 28042992
TWEAK is not elevated in patients with newly diagnosed inflammatory bowel disease.
Scand J Gastroenterol 2017 Apr;52(4):420-424. Epub 2016 des 31
PMID: 28040992
Cancer surveillance in gastroenterology practice.
Best Pract Res Clin Gastroenterol 2016 Dec;30(6):853-854. Epub 2016 nov 10
PMID: 27938780
America, We Are Confused: The Updated U.S. Preventive Services Task Force Recommendation on Colorectal Cancer Screening.
Ann Intern Med 2017 Jan 17;166(2):139-140. Epub 2016 nov 8
PMID: 27820949
Expert opinions and scientific evidence for colonoscopy key performance indicators.
Gut 2016 Oct 08. Epub 2016 okt 8
PMID: 27802153
Performance measures for upper gastrointestinal endoscopy: A European Society of Gastrointestinal Endoscopy quality improvement initiative.
United European Gastroenterol J 2016 Oct;4(5):629-656. Epub 2016 aug 21
PMID: 27733906
Performance measures for upper gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.
Endoscopy 2016 Sep;48(9):843-64. Epub 2016 aug 22
PMID: 27548885
European Society of Gastrointestinal Endoscopy - Establishing the key unanswered research questions within gastrointestinal endoscopy.
Endoscopy 2016 Oct;48(10):884-891. Epub 2016 aug 2
PMID: 27485483
Colonoscopy and Risk of Infective Endocarditis in the Elderly.
J Am Coll Cardiol 2016 Aug 02;68(5):570-1.
PMID: 27470461
Incentives and participation in a medical survey.
Tidsskr Nor Laegeforen 2016 Jul;136(12-13):1082-7. Epub 2016 jul 5
PMID: 27381786
Routine vs. on-demand analgesia in colonoscopy: a randomized clinical trial.
Endoscopy 2016 Sep;48(9):823-8. Epub 2016 jun 15
PMID: 27305424
Pain and sedation during colonoscopy - a never ending story.
Endosc Int Open 2016 May;4(5):E538-9.
PMID: 27227111
Cecal intubation failure: Refer or change technique?
Gastrointest Endosc 2016 Jun;83(6):1245-7.
PMID: 27206588
Recognizing Data Generation.
N Engl J Med 2016 May 12;374(19):1898. Epub 2016 apr 20
PMID: 27096437
Reporting systems in gastrointestinal endoscopy: Requirements and standards facilitating quality improvement: European Society of Gastrointestinal Endoscopy position statement.
United European Gastroenterol J 2016 Apr;4(2):172-6. Epub 2016 feb 3
PMID: 27087943
Rationale and design of the European Polyp Surveillance (EPoS) trials.
Endoscopy 2016 Jun;48(6):571-8. Epub 2016 apr 4
PMID: 27042931
The continuing uncertainty about cancer risk in inflammatory bowel disease.
Gut 2016 Jun;65(6):889-93. Epub 2016 mar 23
PMID: 27008845
Time trends in quality indicators of colonoscopy.
United European Gastroenterol J 2016 Feb;4(1):110-20. Epub 2015 feb 5
PMID: 26966531
The European Society of Gastrointestinal Endoscopy Quality Improvement Initiative: developing performance measures.
United European Gastroenterol J 2016 Feb;4(1):30-41. Epub 2015 des 17
PMID: 26966520
Commentary: "Randomize, Then Consent" or "Consent, Then Randomize"?: Revitalizing the Issue of Preconsent Randomization.
Epidemiology 2016 May;27(3):393-4.
PMID: 26849639
Patient values and preferences on transcatheter or surgical aortic valve replacement therapy for aortic stenosis: a systematic review.
BMJ Open 2016 Sep 29;6(9):e014327. Epub 2016 sep 29
PMID: 27687903
Prognosis after surgical replacement with a bioprosthetic aortic valve in patients with severe symptomatic aortic stenosis: systematic review of observational studies.
BMJ 2016 Sep 28;354():i5065. Epub 2016 sep 28
PMID: 27683072
Introduction to BMJ Rapid Recommendations.
BMJ 2016 Sep 28;354():i5191. Epub 2016 sep 28
PMID: 27680768
Authors seldom report the most patient-important outcomes and absolute effect measures in systematic review abstracts.
J Clin Epidemiol 2016 Aug 21. Epub 2016 aug 21
PMID: 27555080
GRADE Evidence to Decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: Clinical practice guidelines.
BMJ 2016 06 30;353():i2089. Epub 2016 jun 30
PMID: 27365494
Agreements between Industry and Academia on Publication Rights: A Retrospective Study of Protocols and Publications of Randomized Clinical Trials.
PLoS Med 2016 Jun;13(6):e1002046. Epub 2016 jun 28
PMID: 27352244
Living cumulative network meta-analysis to reduce waste in research: A paradigmatic shift for systematic reviews?
BMC Med 2016 Mar 29;14():59. Epub 2016 mar 29
PMID: 27025849
Tailoring implementation strategies for evidence-based recommendations using computerised clinical decision support systems: protocol for the development of the GUIDES tools.
Implement Sci 2016 Mar 05;11():29. Epub 2016 mar 5
PMID: 26946141
Improving GRADE evidence tables part 1: a randomized trial shows improved understanding of content in summary of findings tables with a new format.
J Clin Epidemiol 2016 Jun;74():7-18. Epub 2016 jan 11
PMID: 26791430
A guide for health professionals to interpret and use recommendations in guidelines developed with the GRADE approach.
J Clin Epidemiol 2016 Apr;72():45-55. Epub 2016 jan 6
PMID: 26772609
Psychological effects of colorectal cancer screening: Participants vs individuals not invited.
World J Gastroenterol 2016 Nov 21;22(43):9631-9641.
PMID: 27920484
Changes in health behavior 1 year after testing negative at a colorectal cancer screening: a randomized-controlled study.
Eur J Cancer Prev 2017 Jan 05. Epub 2017 jan 5
PMID: 27824661
Colorectal Cancer Screening.
JAMA 2016 Oct 25;316(16):1714.
PMID: 27784085
Oncogene Mutations in Colorectal Polyps Identified in the Norwegian Colorectal Cancer Prevention (NORCCAP) Screening Study.
Clin Med Insights Pathol 2016;9():19-28. Epub 2016 sep 7
PMID: 27656095
Comparison of the Multiattribute Utility Instruments EQ-5D and SF-6D in a Europe-Wide Population-Based Cohort of Patients with Inflammatory Bowel Disease 10 Years after Diagnosis.
Gastroenterol Res Pract 2016;2016():5023973. Epub 2016 aug 18
PMID: 27630711
Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia.
World J Gastroenterol 2016 Jul 21;22(27):6276-86.
PMID: 27468217
An explorative study from the Norwegian Quality Register Gastronet comparing self-estimated versus registered quality in colonoscopy performance.
Endosc Int Open 2016 Mar;4(3):E326-32. Epub 2016 feb 10
PMID: 27004252
Colorectal Cancer screening with Colonoscopy
- Disputert:
- oktober 2016
- Hovedveileder:
- Michael Bretthauer
- Lars Aabakken Prosjektdeltaker
- Hans-Olov Adami Prosjektdeltaker
- Magnus Løberg Prosjektdeltaker
- Mette Kalager Prosjektdeltaker
- Per Sandvei Prosjektdeltaker
- Ole Næss Prosjektdeltaker
- Birgitte Karen Berggreen Seip Prosjektdeltaker
- Geir Hoff Prosjektdeltaker
- Per Olav Vandvik Prosjektdeltaker
- Øyvind Holte Prosjektdeltaker
- Hans Olov Adami Forsker (annen finansiering)
- Kjetil Kjeldstad Garborg Prosjektdeltaker
- Thomas De Lange Prosjektdeltaker
- Ole Darre-Næess Prosjektdeltaker
- Ole Ingebreth Høie Prosjektdeltaker
- Øyvind Holme Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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