Function of the tumor suppressor Tsg101 in membrane trafficking and cell signalling
- Prosjektnummer
- 3a-104
- Ansvarlig person
- Harald Stenmark, professor
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis
ESCRT proteins in physiology and disease.
Exp Cell Res 2009 May;315(9):1619-26. Epub 2008 okt 28
PMID: 19013455
ESCRTing membrane deformation.
Cell 2009 Jan;136(1):15-7.
PMID: 19135881
The role of ESCRT proteins in attenuation of cell signalling.
Biochem Soc Trans 2009 Feb;37(Pt 1):137-42.
PMID: 19143618
Disruption of Vps4 and JNK function in Drosophila causes tumour growth.
PLoS One 2009;4(2):e4354. Epub 2009 feb 4
PMID: 19194501
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
Nature 2009 Mar;458(7237):445-52.
PMID: 19325624
Multivesicular endosome biogenesis in the absence of ESCRTs.
Traffic 2009 Jul;10(7):925-37. Epub 2009 apr 10
PMID: 19490536
How do ESCRT proteins control autophagy?
J Cell Sci 2009 Jul;122(Pt 13):2179-83.
PMID: 19535733
Autophagy in tumour suppression and promotion.
Mol Oncol 2009 Aug;3(4):366-75. Epub 2009 jun 6
PMID: 19559660
Rab GTPases as coordinators of vesicle traffic.
Nat Rev Mol Cell Biol 2009 Aug;10(8):513-25. Epub 2009 jul 15
PMID: 19603039
Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.
J Cell Sci 2009 Nov;122(Pt 21):3883-93. Epub 2009 okt 6
PMID: 19808888
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking.
Exp Cell Res 2008 Feb;314(4):801-13. Epub 2007 nov 26
PMID: 18031739
Cell-cycle-dependent binding kinetics for the early endosomal tethering factor EEA1.
EMBO Rep 2008 Feb;9(2):171-8. Epub 2008 jan 11
PMID: 18188183
Mechanisms and functions of endocytosis.
J Cell Biol 2008 Jan;180(1):7-11.
PMID: 18195098
An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor.
J Cell Biol 2008 Mar;180(6):1205-18.
PMID: 18362181
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation.
Mol Biol Cell 2008 Aug;19(8):3454-62. Epub 2008 mai 28
PMID: 18508924
Membranes and organelles.
Curr Opin Cell Biol 2008 Aug;20(4):357-9. Epub 2008 jul 7
PMID: 18588977
Self-eating from an ER-associated cup.
J Cell Biol 2008 Aug;182(4):621-2.
PMID: 18725534
Developmental biology: moonlighting at the pole.
Nature 2007 Feb;445(7127):497-9.
PMID: 17268460
Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling.
Biochimie 2007 May;89(5):637-57. Epub 2007 jan 21
PMID: 17335953
Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation.
Traffic 2007 Nov;8(11):1617-29. Epub 2007 aug 20
PMID: 17714434
ESCRTs and Fab1 regulate distinct steps of autophagy.
Curr Biol 2007 Oct;17(20):1817-25. Epub 2007 okt 11
PMID: 17935992
Aberrant receptor signaling and trafficking as mechanisms in oncogenesis.
Crit Rev Oncog 2007;13(1):39-74.
PMID: 17956217
RILP is required for the proper morphology and function of late endosomes.
J Cell Sci 2007 Nov;120(Pt 21):3729-37.
PMID: 17959629
Endocytic trafficking of membrane proteins. Mechanisms in human disease.
- Disputert:
- november 2009
- Hovedveileder:
- Harald Stenmark
The role of ESCRT proteins and phosphoinositides in MVE biogenesis, endocytic trafficking and disease.
- Disputert:
- januar 2009
- Hovedveileder:
- Andreas Brech
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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