Prevention of Allergy Among Children in Trondheim (PACT) Study
- Prosjektnummer
- 46040100
- Ansvarlig person
- Torbjørn Øien
- Institusjon
- NTNU, ISM
- Prosjektkategori
- Flerårig prosjekt 2010
- Helsekategori
- Inflammatory and Immune System, Skin
- Forskningsaktivitet
- 2. Aetiology, 3. Prevention
ProPACT studien inngår i flere metanalyser som tross heterogenisitet viser at probiotika gitt i slutten av svangerskapet og under amming har en forebyggende effekt mot atopisk eksem. World Allergy Organisation gir nå gir anbefaling om bruk av probiotika i primærforebygging av atopisk dermatitt i familier med høy risiko for atopisk eksem.
Effect of probiotics in prevention of atopic dermatitis is dependent on the intrinsic microbiota at early infancy.
J Allergy Clin Immunol 2017 Apr;139(4):1399-1402.e8. Epub 2016 des 5
PMID: 27931973
Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation.
Clin Exp Allergy 2017 Aug;47(8):1014-1021. Epub 2017 apr 21
PMID: 28346719
Early gut mycobiota and mother-offspring transfer.
Microbiome 2017 Aug 24;5(1):107. Epub 2017 aug 24
PMID: 28837002
Diversity of vaginal microbiota increases by the time of labor onset.
Sci Rep 2017 Dec 14;7(1):17558. Epub 2017 des 14
PMID: 29242550
Transition from infant- to adult-like gut microbiota.
Environ Microbiol 2016 Jul;18(7):2226-36. Epub 2016 mar 21
PMID: 26913851
Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediated by breast milk TSLP or TGF-ß.
Clin Transl Allergy 2016;6():27. Epub 2016 jul 22
PMID: 27453775
Major faecal microbiota shifts in composition and diversity with age in a geographically restricted cohort of mothers and their children.
FEMS Microbiol Ecol 2014 Jan;87(1):280-90. Epub 2013 okt 17
PMID: 24112053
The predictive value of allergen skin prick tests and IgE tests at pre-school age: The PACT study.
Pediatr Allergy Immunol 2014 Nov;25(7):691-8. Epub 2014 nov 21
PMID: 25298031
Bifidobacterial succession and correlation networks in a large unselected cohort of mothers and their children.
Appl Environ Microbiol 2013 Jan;79(2):497-507. Epub 2012 nov 2
PMID: 23124244
The impact of pre- and postnatal exposures on allergy related diseases in childhood: a controlled multicentre intervention study in primary health care.
BMC Public Health 2013;13():123. Epub 2013 feb 8
PMID: 23394141
Diversity of intestinal microbiota in infancy and the risk of allergic disease in childhood.
Curr Opin Allergy Clin Immunol 2013 Jun;13(3):257-62.
PMID: 23549152
Agreement of specific IgE and skin prick test in an unselected cohort of two-year-old children.
Eur J Pediatr 2012 Mar;171(3):479-84. Epub 2011 sep 30
PMID: 21960289
Modelling bacterial transmission in human allergen-specific IgE sensitization.
Lett Appl Microbiol 2012 May;54(5):447-54. Epub 2012 mar 19
PMID: 22385401
Early eczema and the risk of childhood asthma: a prospective, population-based study.
BMC Pediatr 2012;12():168. Epub 2012 okt 24
PMID: 23095804
Family eczema-history in 2-year-olds with eczema; a prospective, population-based study. The PACT-study, Norway.
BMC Dermatol 2011;11():11. Epub 2011 mai 20
PMID: 21599876
Temporal development of the infant gut microbiota in immunoglobulin E-sensitized and nonsensitized children determined by the GA-map infant array.
Clin Vaccine Immunol 2011 Aug;18(8):1326-35. Epub 2011 jun 8
PMID: 21653746
Temporal variations in early gut microbial colonization are associated with allergen-specific immunoglobulin E but not atopic eczema at 2 years of age.
Clin Exp Allergy 2011 Nov;41(11):1545-54. Epub 2011 jul 13
PMID: 21749499
Do early intake of fish and fish oil protect against eczema and doctor-diagnosed asthma at 2 years of age? A cohort study.
J Epidemiol Community Health 2010 Feb;64(2):124-9. Epub 2009 aug 6
PMID: 19666630
A primary health-care intervention on pre- and postnatal risk factor behavior to prevent childhood allergy. The Prevention of Allergy among Children in Trondheim (PACT) study.
BMC Public Health 2010;10():443. Epub 2010 jul 28
PMID: 20667103
Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial.
Br J Dermatol 2010 Sep;163(3):616-23. Epub 2010 jun 9
PMID: 20545688
Allergy related disorders among 2-yrs olds in a general population. The PACT Study.
Pediatr Allergy Immunol 2010 Mar;21(2 Pt 1):315-20. Epub 2009 des 9
PMID: 20003067
Intake of fish during the first year of life is associated with a reduced risk of asthma at 6 years of age. A cohort study
Hovedoppgave medisin
Tidstrender i prevalens av allergirelaterte sykdommer som astma, eksem og høysnue blant 6-åringer i Tr.h perioden 2000 til 2009
Hovedoppgave - Medisin
Primary prevention of allergy related diseases in primary healt care
Forskerlinjeoppgave - Medisin
Probiotics in pregnanct women to prevent allergic diseseases - a randomised, double.blin
Hovedoppgave - medisin
Gut Microbiota and Infantil colic
Hovedoppgave - Medisin
Prediction of allergy-related diseases
- Disputert:
- september 2017
- Hovedveileder:
- Torbjørn Øien
Primary prevention of atopic diseases
- Disputert:
- mai 2016
- Hovedveileder:
- Torbjørn Øien
Eczema in children and adolescents - epidemiology, course and impact
- Disputert:
- mai 2012
- Hovedveileder:
- Roar Johnsen
Modification of adjuvant risk factor behaviours for allergic disease and association between early gut microbiota and atopic sen
- Disputert:
- desember 2011
- Hovedveileder:
- Roar Johnsen
Allergy related disorders among 2-year olds and adolescents in Mid-Norway
- Disputert:
- mai 2010
- Hovedveileder:
- Ann Hildur Henriksen
Challenges in prevention of allergy
- Disputert:
- april 2010
- Hovedveileder:
- Roar Johnsen
- Ekaterina Avershina Prosjektdeltaker
- Knut Rudi Prosjektdeltaker
- Vibeke Videm Medveileder, biveileder
- Ola Storrø Medveileder, biveileder
- Anne Dorthea Bjerkenes Rø Doktorgradsstipendiat
- Melanie Rae Simpson Doktorgradsstipendiat
- Torbjørn Øien Prosjektleder
- kasper Schei Prosjektdeltaker
- Roar Johnsen Prosjektdeltaker
- Christian Dotterud Doktorgradsstipendiat
- Gaute Brede Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU