Cell-specific changes in metabolism and transmission as an initial cause of Alzheimer’s disease
- Prosjektnummer
- 46060919
- Ansvarlig person
- Menno Witter
- Institusjon
- NTNU, Kavliinstituttet
- Prosjektkategori
- Flerårig prosjekt
- Helsekategori
- Neurological
- Forskningsaktivitet
- 1. Underpinning, 4. Detection and Diagnosis
The project is still at a very fundamental stage, but has provided the basis for a pending application for a Jebsen center on Alzheimer's disease, we are preparing to apply to JPND, deadline 3 March 2020, and the work is part of a CARG and will be part of the second attempt to obtain funding for a CAG, the latter two initiatives are headed by INB/Sandvig group. At KIN, we have obtained a US patent on a viral approach to genetically interfere with AD in an early state, and we are working to develop this further within an international consortium, together with colleagues in Denmark, US and Japan.
The newly developed viral gene editing approach will open ways to control levels of Abeta in the brain and may eventually lead to a new treatment for AD. The patent is about this, but we do need many additional tests, so no consequences for patients and health services yet.
The experiments were meant to provide insights in basic mechanisms in neurons which we hypothesize to form the initiators of Alzheimer's disease. These data will and already have lead to a number of new internationally funded projects, aiming to develop a clinically applicable treatment. We have obtained a pending patent to manipulate the relevant neurons and are in the process of developing approaches to test our approach in non-human primates with colleagues in Japan and in the US. We have high hopes that eventually, through gene editing of specific neurons, we might be able to prevent the development of AD.
Electrophysiological characterization of networks and single cells in the hippocampal region of a transgenic rat model of Alzheimer’s disease
eNeuro 2019 DOI 10.1523/ENEURO.0448-17.2019
Structural and functional changes in the hippocampal region of a transgenic rat model of Alzheimer's disease
- Disputert:
- mai 2016
- Hovedveileder:
- Menno Witter
- Eirik Stamland Nilssen Postdoktorstipendiat
- Ingrid Heggland Postdoktorstipendiat
- Belma Skender Postdoktorstipendiat
- Geir Bjørkøy Medveileder, biveileder
- Menno Witter Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU