Immunity alterations in patients with inflammatory bowel disease: the role of gammadelta T lymphocytes, interleukin 7, and Microsporidia infection.
- Prosjektnummer
- 90057700
- Ansvarlig person
- Ignacio Catalan Serra
- Institusjon
- NTNU, MH-fakultetet, Institutt for klinisk og molekylær medisin
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Inflammatory and Immune System
- Forskningsaktivitet
- 2. Aetiology
This project is helping us to better understand why patients get chronic inflammation in the gut (IBD). The study and characterization of the immune response against our own microbiota is a key issue to understand the cause and natural history of the disease. The role of some special T lymphocytes called unconventional T cells is revealing as relevant in the maintenance of the inflammatory state in the intestine. Understanding the composition of our microbiota, including the fungi colonizing the gut, and the role of opportunistic infections is important to figure out how they can complicate the disease course and eventually lead to specific treatments against them to avoid colonization and inflammation. Moreover, this research line can help to use the immune response as a diagnostic and prognostic marker in IBD, helping the clinicians to make better therapeutic decisions avoiding unnecessary side effects. Finally, this studies can allow researchers and clinicians to understand how current treatments impact the immune response to personalize the treatment and eventually, to identify new and more precise therapeutic targets.
"Out of the box" new therapeutic strategies for Crohn´s disease: moving beyond biologics.
Rev Esp Enferm Dig 2023 Nov;115(11):614.
PMID: 35748460
Young GI angle: Working abroad with the family: Mission impossible?
United European Gastroenterol J 2021 10;9(8):982-983.
PMID: 34622563
Gammadelta T cells as a predictor of surgical relapse of Crohn's disease.
Clin Res Hepatol Gastroenterol 2020 09;44(4):586-597. Epub 2019 des 18
PMID: 31864955
Immunotherapy in inflammatory bowel disease: Novel and emerging treatments.
Hum Vaccin Immunother 2018;14(11):2597-2611. Epub 2018 mai 22
PMID: 29624476
B1a Lymphocytes (CD19+CD5+) Deficiency in Patients with Crohn's Disease and Its Relation with Disease Severity.
Dig Dis 2018;36(3):194-201. Epub 2018 feb 8
PMID: 29421816
Gammadelta T Cells: Unconventional T Cells Involved in IBD Pathogenesis.
Dig Dis Sci 2018 May 11. Epub 2018 mai 11
PMID: 29752622
Gammadelta T Cells in Crohn's Disease: A New Player in the Disease Pathogenesis?
J Crohns Colitis 2017 Sep 01;11(9):1135-1145.
PMID: 28333360
Determination of Anti-Anisakis Simplex Antibodies and Relationship with αβ and γδ Lymphocyte Subpopulations in Patients with Crohn's Disease.
Dig Dis Sci 2017 04;62(4):934-943. Epub 2017 feb 6
PMID: 28168577
P712 Fungal microbiota composition in Inflammatory Bowel Disease patients in a Norwegian cohort: characterization of disease phenotypes and correlation with clinical activity and disease course.
Poster presentations: Microbiology 2022 P712. Journal of Crohn`s and Colitis. 2022- ECCO Congress 2022
Prevalence of anti-anisakis simplex antibodies in patients with inflammatory bowel disease (IBD) in Norway. correlation with disease phenotype and clinical activity. UEG Journal. United European Gastroenterology Week 2020 (P147)
UEGJ, 2020
Characterization of fungal microbiota in a Norwegian IBD cohort.
Journal of Crohn ́s and Colitis 2019. Copenhagen. ECCO 2019 (P835).
Gammadelta t cells deficiency in the peripheral blood of patients with crohn's disease: inverse correlation with clinical and endoscopical activity
DDW. Gastroenterology.2017.:5(Suppl1):S616
Gamma delta T cells deficit in the peripheral blood of patients with CD: relationship with clinical and endoscopical activity.
UEG Journal. 2016:4 (Suppl 1): A:1351
Gamma delta T cells deficit in the peripheral blood of patients with CD: relationship with clinical and endoscopical activity.
Gamma delta T cell Conference. 2016. London , UK. Poster B-47.
- Elin Synnøve Røyset Doktorgradsstipendiat
- Ingunn Bakke Forsker
- Torunn Bruland Medveileder, biveileder
- Arne Kristian Sandvik Prosjektleder
- Ignacio Catalan Serra Postdoktorstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Helse Midt-Norge RHF - Samarbeidsorganet og FFU