Stimulated differentiation of native human acute myelogenous leukemia (AML) blasts as a potential cancer-specific therapeutic target: clinical and experimental studies
- Prosjektnummer
- 911225
- Ansvarlig person
- Anita Ryningen
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Hematology
- Forskningsaktivitet
- Grunnforskning
Clonogenic acute myelogenous leukemia cells are heterogeneous with regard to regulation of differentiation and effect of epigenetic pharmacological targeting.
Leuk Res 2007 Sep;31(9):1303-13. Epub 2007 apr 9
PMID: 17416413
Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors.
Int J Oncol 2007 Dec;31(6):1529-38.
PMID: 17982680
Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells.
Haematologica 2007 Mar;92(3):332-41.
PMID: 17339182
T lymphocyte chemotactic chemokines in acute myelogenous leukemia (AML): local release by native human AML blasts and systemic levels of CXCL10 (IP-10), CCL5 (RANTES) and CCL17 (TARC).
Cancer Immunol Immunother 2006 Jul;55(7):830-40. Epub 2005 nov 3
PMID: 16267679
Acute myelogenous leukemia in a patient with Li-Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report.
Leukemia 2006 Apr;20(4):734-6.
PMID: 16437140
Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML.
Expert Opin Ther Targets 2006 Feb;10(1):51-68.
PMID: 16441228
Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2:Bax ratio and low levels of heat shock protein 70 and 90.
Leuk Res 2006 Dec;30(12):1531-40. Epub 2006 apr 5
PMID: 16600371
Treatment with valproic acid, all-trans retinoic acid (ATRA) and theophyllamine for 9 days caused a persistent increase in peripheral blood platelet counts for a patient with acute myelogenous leukemia.
Acta Oncol 2006;45(3):346-9.
PMID: 16644583
Microvascular endothelial cells increase proliferation and inhibit apoptosis of native human acute myelogenous leukemia blasts.
Int J Cancer 2006 Nov;119(10):2313-21.
PMID: 16921487
Reticulated platelets are increased in chronic myeloproliferative disorders, pure erythrocytosis, reactive thrombocytosis and prior to hematopoietic reconstitution after intensive chemotherapy.
Platelets 2006 Aug;17(5):296-302.
PMID: 16928601
Effects of histone deacetylase inhibitors on native human acute myelogenous leukaemia cells
Molecular Pharmacology
Epigenetic targeting in acute myeloid leukemia: use of flow cytometry in monitoring therapeutic effects
Current Pharmaceutical Biotechnology
Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in c
Current Pharmaceutical Biotechnology
Treatment with valproic acid, all-trans retinoic acid (ATRA) and theophyllamine for 9 days caused an early increase in reticulat
Acta oncologica, in press
RNAi mediated knock-down of the hARD1 and NATH components of the protein N--acetyltransferase complex triggers apoptosis
Oncogene, in press
Reticulated platelets in peripheral blood are increased in chronic myeloproliferative disorders, pure erythrocytosis of unknown
Platelets, in press
The possible use of histone deacetylase inhibitors in the treatment of acute myelogenous leukemia
Expert Opinion on Therapeutic Targets, in press
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest