Identification and testing of novel apoptosis inductors in AML cells in vitro and in vivo
- Prosjektnummer
- 911236
- Ansvarlig person
- Stein Ove Døskeland
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Hematology
- Forskningsaktivitet
- Translasjonsforskning
cAMP-dependent signaling regulates the adipogenic effect of n-6 polyunsaturated fatty acids.
J Biol Chem 2008 Mar;283(11):7196-205. Epub 2007 des 10
PMID: 18070879
Cyclic adenosine 3',5'-monophosphate (cAMP)-dependent protein kinases, but not exchange proteins directly activated by cAMP (Epac), mediate thyrotropin/cAMP-dependent regulation of thyroid cells.
Endocrinology 2007 Oct;148(10):4612-22. Epub 2007 jun 21
PMID: 17584967
LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro.
Mol Cancer 2007;6():31. Epub 2007 apr 23
PMID: 17451600
CaM-kinaseII-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation.
Cell Death Differ 2006 Jul;13(7):1191-202. Epub 2005 nov 25
PMID: 16311514
Microcystin produces disparate effects on liver cells in a dose dependent manner.
Mini Rev Med Chem 2006 Mar;6(3):279-85.
PMID: 16515466
Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition.
J Biol Chem 2006 Jul;281(30):21500-11. Epub 2006 mai 25
PMID: 16728394
Proteomic and computational methods in systems modeling of cellular signaling.
Curr Pharm Biotechnol 2006 Jun;7(3):135-45.
PMID: 16789899
Does isoform diversity explain functional differences in the 14-3-3 protein family?
Curr Pharm Biotechnol 2006 Jun;7(3):217-23.
PMID: 16789906
Substrate enhances the sensitivity of type I protein kinase a to cAMP.
J Biol Chem 2005 Apr;280(14):13279-84. Epub 2005 feb 3
PMID: 15691833
A high proportion of Baltic Sea benthic cyanobacterial isolates contain apoptogens able to induce rapid death of isolated rat hepatocytes.
Toxicon 2005 Sep;46(3):252-60.
PMID: 15990143
Neuro-apoptogenic and blood platelet targeting toxins in benthic marine cyanobacteria from the Portuguese coast.
Aquat Toxicol 2005 Sep;74(4):294-306.
PMID: 16039729
Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death
Poster. The EMBO Conference on Protein Synthesis and Translational Control - Partnered with Cold Spring Harbor Laboratories, 12 th-16th Sep 2007, Heidelberg, Germany.
Chemotherapy-induced traffic jam
Poster. Intracellular Transport and Signal Transduction in Cancer Biomedicine, 19 th -23 th May 2007, Nærøy, Norway
Serine/Threonine protein phosphatases in apoptosis
Apoptosis, cell signaling and human diseases, Molecular mechanisms, Vol 2, Ed Rakesh Srivastava, Human Press
Chemotherapy-induced traffic jam
Poster. Keystone Symposia, “Apoptotic and Non-apoptotic cell death pathways”, 15 th -20 th April 2007, Monterey, California, USA.
Bioactive compounds from marine microorganisms: search for anti-leukemic drugs and finding mechanisms of action
Masteroppgave Institutt for biomedisin Universitetet i Bergen
New lessons from an "old" drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia
- Disputert:
- desember 2007
- Hovedveileder:
- Stein Ove Døskeland (50%) og Bjørn Tore Gjertsen(50%)
Apoptosis modulating and anti-thrombotic activities from marine micro-organisms
- Disputert:
- august 2006
- Hovedveileder:
- Stein Ove Døskeland
The role of CaMKII and cA-PK in control of cell survival and death
- Disputert:
- februar 2005
- Hovedveileder:
- Stein Ove Døskeland
Novel aspects of regulation and activation of the cAMP-dependent protein kinase
- Disputert:
- desember 2005
- Hovedveileder:
- Stein Ove Døskeland
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest