Cancer thyroideae - molekylærbiologi og klinikk
- Prosjektnummer
- 911273
- Ansvarlig person
- Thomas Arnesen
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskerutdanning - postdoc
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity.
J Biol Chem 2009 Nov;284(45):31122-9. Epub 2009 sep 10
PMID: 19744929
Composition and biological significance of the human Nalpha-terminal acetyltransferases.
BMC Proc 2009;3 Suppl 6():S3. Epub 2009 aug 4
PMID: 19660096
A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates.
BMC Proc 2009;3 Suppl 6():S2. Epub 2009 aug 4
PMID: 19660095
Protein N-terminal acetylation: NAT 2007-2008 Symposia.
BMC Proc 2009;3 Suppl 6():S1. Epub 2009 aug 4
PMID: 19660094
Involvement of N-acetyltransferase human in the cytotoxic activity of 5-fluorouracil.
Anticancer Drugs 2009 Sep;20(8):668-75.
PMID: 19561488
A novel human NatA Nalpha-terminal acetyltransferase complex: hNaa16p-hNaa10p (hNat2-hArd1).
BMC Biochem 2009;10():15. Epub 2009 mai 29
PMID: 19480662
The protein Nalpha-terminal acetyltransferase hNaa10p (hArd1) is phosphorylated in HEK293 cells.
BMC Res Notes 2009;2():32. Epub 2009 mar 2
PMID: 19284711
Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.
Mol Cell Biol 2009 Jul;29(13):3569-81. Epub 2009 apr 27
PMID: 19398576
Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans.
Proc Natl Acad Sci U S A 2009 May;106(20):8157-62. Epub 2009 mai 6
PMID: 19420222
The protein acetyltransferase ARD1: a novel cancer drug target?
Curr Cancer Drug Targets 2008 Nov;8(7):545-53.
PMID: 18991565
Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression.
Biochem J 2008 Oct;415(2):325-31.
PMID: 18570629
Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-alpha-acetyltransferase complex.
Gene 2006 Apr;371(2):291-5. Epub 2006 feb 28
PMID: 16507339
Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex.
Oncogene 2006 Jul;25(31):4350-60. Epub 2006 mar 6
PMID: 16518407
Characterization of hARD2, a processed hARD1 gene duplicate, encoding a human protein N-alpha-acetyltransferase.
BMC Biochem 2006;7():13. Epub 2006 apr 25
PMID: 16638120
A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family.
Genes Chromosomes Cancer 2006 Dec;45(12):1155-63.
PMID: 17001621
Carboxyl terminus of Hsc70-interacting protein is required for ubiquitination and acetylation-mediated degradation of HIF-1 a
CLINICAL & EXPERIMENTAL METASTASIS 2009 26(7):905
Identification and characterization of the human N-acetyltransferase complexes hNatB and hNatC.
FASEB J. 2009 23:LB208
Human Nat5/San, a novel protein expressing both N-alpha and N-epsilon acetyltransferase activity
FASEB J. 2009 23:LB188
Protein N-terminal acetyltransferases (NATs) in human cells.
NAT-2008 International symposium. Bergen. Oral presentation
The human NatA protein N-terminal acetyltransferase complex: important for cancer cell proliferation and evasion of apoptosis –
Bergen Conference on Cancer Research. Solstrand. Oral presentation
Protein N-a-acetylation analyzed by N-terminal COFRADIC.
Human Proteome (HUPO) World Congress. Amsterdam. Poster presentation
N-terminal protein acetylation in yeast.
Yeast Genetics and Molecular Biology Meeting. Toronto. Poster presentation
The novel hNatB complex is important for cell cycle progression.
Bergen Conference on Cancer Research. Solstrand. Oral presentation
The human NatB and NatC complexes.
NAT-2008 International symposium. Bergen. Oral presentation
hARD1 regulates growth and death of cancer cell lines
NAT-2008 International symposium. Bergen. Oral presentation
The human N-acetyltransferase complex NatC
BCCR, Solstrand Mai 2007
Protein N-terminal acetyltransferases (NATs) in human cells
NAT-symposium, Bergen, Mai 2007
HIF-1α and ARD1: enemies, friends or neither?
Nature Reviews Cancer, 2006. 6 (3): doi:10.1038/nrc1779-c1.
Interaction between HIF-1alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1alpha
BCCR, Solstrand, Mai 2006
Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltran
BCCR, Solstrand, Mai 2006
NATH and hARD1, components of the human NatA protein N-alpha-acetyltransferase complex: characterization of cellular function
- Disputert:
- februar 2006
- Hovedveileder:
- Jan Erik Varhaug
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest