Utvikling av proteomikk biomarkører for tidlig diagnose av multippel sklerose
- Prosjektnummer
- 911355
- Ansvarlig person
- Rune J. Ulvik
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Neurological
- Forskningsaktivitet
- 4. Detection and Diagnosis
Short commentary on 'a consensus protocol for the standardization of cerebrospinal fluid collection and biobanking'.
Mult Scler 2010 Feb;16(2):129-32. Epub 2009 des 30
PMID: 20042453
A multivariate approach to reveal biomarker signatures for disease classification: application to mass spectral profiles of cerebrospinal fluid from patients with multiple sclerosis.
J Proteome Res 2010 Jul;9(7):3608-20.
PMID: 20499859
Proteomics of human cerebrospinal fluid: discovery and verification of biomarker candidates in neurodegenerative diseases using quantitative proteomics.
J Proteomics 2011 Apr;74(4):371-88. Epub 2010 nov 25
PMID: 21111852
IsobariQ: software for isobaric quantitative proteomics using IPTL, iTRAQ, and TMT.
J Proteome Res 2011 Feb;10(2):913-20. Epub 2010 nov 29
PMID: 21067241
Optimizing performance of glycopeptide capture for plasma proteomics.
J Proteome Res 2010 Apr;9(4):1706-15.
PMID: 20235580
A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking.
Neurology 2009 Dec;73(22):1914-22.
PMID: 19949037
Cerebrospinal fluid biomarkers in multiple sclerosis.
Neurobiol Dis 2009 Aug;35(2):117-27. Epub 2009 mai 5
PMID: 19426803
Discriminating variable test and selectivity ratio plot: quantitative tools for interpretation and variable (biomarker) selection in complex spectral or chromatographic profiles.
Anal Chem 2009 Apr;81(7):2581-90.
PMID: 19228047
Pretreatment of mass spectral profiles: application to proteomic data.
Anal Chem 2007 Sep;79(18):7014-26. Epub 2007 aug 21
PMID: 17711295
Biomarker discovery in mass spectral profiles by means of selectivity ratio plot.
Chemometrics and Intelligent Laboratory Systems 2009 ;Volum 95.(1) s. 35-48
X-tended target projection - compartison with orthogonal partial least squares (OPLS) and PLS post processing by similarity
J Chemometrics 2009; 23: 49 - 55
Comprehensive proteomics based biomarker discovery study for multiple sclerosis
Nasjonalt proteomikkmøte, Bergen 2009
Early diagnosis and biomarker discovery from mass spectral profiles
The 11th Scandinavian Symp. on chemometrics, 2009, Loen, Norge
Discriminating variable test and selectivity ratio plot - qunatitative tools for interpretation and variable ( biomarker).
The 11th Scandinavian Symp. on chemometrics, 2009, Loen, Norge
Discovery of novel diagnostic biomarker candidates for multiple sclerosis through clinical proteomics
Nasonalt møte, Norsk proteomikkforening, Bergen, 2009
Comprehensive proteomics based on biomarker discovery study for multiple sclerosis
Nasonalt møte, Norsk proteomikkforening, Bergen, 2009
Biomarker discovery in mass spectral profiles by means of selectivity ratio plot.
Chemometrics Intell.Lab.Syst. ( 2008), doi: 10.1016/j.chemolab.2008.08.004
X-tended target projection (XTP) ? Comparison with orthogonal partiel least squares (OPLS) and PLS post-processing by similarity
J. Chemometrics (2008), doi:10.1002/chem. 1193, on line
Proteomikk, biomarkører og kjemometri.
Norsk Kjemometrisymposium, Voss 3.-5. mars 2008
Spectral profiling and biomarker selection in metabolomics and proteomics-application to diabetes and multiple sclerosis
Workshop on recent progress in chemical fingerprint-bioactivity analysis techniques of Chinese medicine. Hong Kong 18.10.2008
Biomarker discovery from mass spectral profiles: A combined proteomics and multivariate analysis.
19th Helsinki Drug Research 2008, June 9-11, Helsinki, Finland. Eur. J.Pharmaceut Sci. 2008;34:S27
Early diagnosis and biomarker discovery from mas spectral profiles: application to multiple sclerosis.
World congress on Treatment and Research in Multiple sclerosis, September 17 – 20, 2008, Montreal, Canada
Discovery of biomarkers in multiple sclerosis.
The NeuroUnit Biomarkers for Inflammation and Neurodegeneration (NUBIN) Symposium 2008, June 12-13, Amsterdam, Nederland
Evaluation of different molecular weight cut-off filters and pre-analytical factors for biomarker discovery in CSF
GOR Summit 2008. Proteomic sample preparation. 19.-20. May, 2008, Boston, USA
Biomarker discovery in cerebro spinal fluid of patients with multiple sclerosis.
NUBI-symposium 2008, June 12-13, Amsterdam, Nederland
Pre-analytical influence on the low molecular weight cerebrospinal fluid proteome
Proteomics Clin.Appl. 2007, 1:699-711
Importance of pre-analytical standardization in diagnostic proteomics
Vårmøte Norsk Selskap for Medisinsk Biokjemi, Klækken 2007
Proteomics-based biomarker discovery in cerebrospinal fluid of multiple sclerosis patients
Norsk MS register og biobankmøte, Oslo, 2007
The influence of pre-analytical variables on the low MW CSF proteome.
6th Dutch Endo-Neuro-Psycho Meeting, Doorwerth, the Netherlands, 2007
Mass spectral profiling and multivariate analysis for detection of biomarker signatures; application to multiple sclerosis
- Disputert:
- oktober 2010
- Hovedveileder:
- Kjell-Morten Myhr
Computational methods in high-throughput proteomics research
- Disputert:
- oktober 2007
- Hovedveileder:
- Ingvar Eidhammer
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest