Functional epigenomics in cancer and cancer therapy
- Prosjektnummer
- 911401
- Ansvarlig person
- Karl-Henning Kalland
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer.
PLoS One 2011;6(1):e14632. Epub 2011 jan 31
PMID: 21297939
Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model.
Exp Cell Res 2011 Jan;317(2):234-47. Epub 2010 okt 20
PMID: 20969863
High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer.
Br J Cancer 2011 Mar;104(6):921-6. Epub 2011 feb 22
PMID: 21343929
Gene expression patterns related to vascular invasion and aggressive features in endometrial cancer.
Am J Pathol 2011 Feb;178(2):861-71.
PMID: 21281818
Transcribed DNA is preferentially located in the perichromatin region of mammalian cell nuclei.
Exp Cell Res 2010 Nov. Epub 2010 nov 5
PMID: 21056558
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Eur J Haematol 2010 Mar;84(3):239-51. Epub 2009 nov 17
PMID: 19922462
Stathmin is superior to AKT and phospho-AKT staining for the detection of phosphoinositide 3-kinase activation and aggressive endometrial cancer.
Histopathology 2010 Oct;57(4):641-6.
PMID: 20955391
Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells.
BMC Genomics 2010;11():669. Epub 2010 nov 25
PMID: 21108828
Cytokines are produced locally by myocytes in rat skeletal muscle during endotoxemia.
Am J Physiol Heart Circ Physiol 2009 Mar;296(3):H735-44. Epub 2009 jan 16
PMID: 19151248
Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype.
Neuropathol Appl Neurobiol 2009 Aug;35(4):380-93.
PMID: 19508445
Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators.
Br J Haematol 2009 Jan;144(1):53-68. Epub 2008 okt 30
PMID: 19016730
Tumour virology--history, status and future challenges.
APMIS 2009 May;117(5-6):382-99.
PMID: 19400863
Hyperoxic treatment induces mesenchymal-to-epithelial transition in a rat adenocarcinoma model.
PLoS One 2009;4(7):e6381. Epub 2009 jul 28
PMID: 19636430
Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia.
BMC Cancer 2009;9():77. Epub 2009 mar 5
PMID: 19265549
TMPRSS2:ERG fusion transcripts in urine from prostate cancer patients correlate with a less favorable prognosis.
APMIS 2009 Aug;117(8):575-82.
PMID: 19664128
Visualisation of RNA by electron microscopic in situ hybridisation.
Methods Mol Biol 2009;464():403-13.
PMID: 18951197
Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation.
Proc Natl Acad Sci U S A 2009 Mar;106(12):4834-9. Epub 2009 mar 4
PMID: 19261849
Genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis.
PLoS One 2009;4(3):e4687. Epub 2009 mar 5
PMID: 19262738
WDR19 expression is increased in prostate cancer compared with normal cells, but low-intensity expression in cancers is associated with shorter time to biochemical failures and local recurrence.
Clin Cancer Res 2008 Mar;14(5):1397-406.
PMID: 18316561
Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma.
Br J Cancer 2008 May;98(10):1662-9. Epub 2008 mai 13
PMID: 18475299
Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation.
PLoS One 2008;3(10):e3368. Epub 2008 okt 13
PMID: 18852876
Molecular Microbial Diagnostics
In: Molecular Biology and Biotechnology, Chapter 4. 5th Ed. Eds: J.M. Walker and Rapley R. Royal Society of Chemistry. Cambridge UK, 2009
A novel model of stepwise prostate carcinogenesis in culture.
Stem Cell Conference, Singapore, February 12-13, 2009
Genome-wide profiling of histone H3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogen
Chromatin Conference: Histones, Nucleosomes, Chromosomes and Genomes, Singapore, February 9-11, 2009.
Epithelial to mesenchymal transition of a primary prostate cell line before malignant transformation with switches of cell adhes
Proceedings 100th Annual Meeting, Denver, USA, April 17 – 22, 2009
Suppression of heat shock Protein 27 induces long-term dormancy in human breast cancer.
Proceedings 100th Annual Meeting, Denver, USA, April 17 – 22, 2009
Highly infiltrative brain tumors show reduced chemosensitivity associated with a stem cell-like phenotype
Proceedings AACR 100th Annual Meeting, Denver, USA, April 17 – 22, 2009
Genome-wide profiling of histone H3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogen
Proceedings AACR 100th Annual Meeting, Denver, USA, April 17 – 22, 2009
A novel cell culture model and its utility in phenotypic screening of small molecular compounds
SMMU, Shanghai, April 25th 2009
Stathmin is superior to AKT and pAKT staining to detect PI3Kinase activation and aggressive endometrial cancer
10th Bergen Conference on Cancer Research, Solstrand Hotel & Bad 19 - 20 May, 2009
EMT Promotes Malignant Transformation of Prostate Epithelial Cells in Culture.
10th Bergen Conference on Cancer Research, Solstrand Hotel & Bad 19 - 20 May, 2009
Genome-wide profiling of histone H3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogen
10th Bergen Conference on Cancer Research, Solstrand Hotel & Bad 19 - 20 May, 2009
Hyperoxic Treatment induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model
Fifth International Conference on Tumor Microenvironment: Progression, Therapy & PreventionVersailles, France. Progression, Therapy and Prevention, Versailles, France, October 20-24, 2009
Stepwise prostate carcinogenesis in vitro culture
Frontiers in Basic Cancer Research, Boston, USA, October 8 – 12, 2009
Stathmin is superior to AKT and Phospho-AKT staining to detect PI3Kinase activation and aggressive endometrial cancer
Phospho-AKT staining to detect PI3Kinase activation and aggressive endometrial cancer. 16th International Meeting of the European Society of Gynecological Oncology, Belgrade, Serbia, October 11 – 14, 2009
Global profiling of histone and DNA methylation reveals epigenetic-based gene regulation during EMT and transformation in a pros
P.R. China, November 3 – 7, 2009
Global profiling of histone and DNA methylation reveals epigenetic-based gene regulation during EMT and transformation in a pros
Abcam, Chromatin meeting, Costa Rica, November 16 – 19, 2009
ERG and SIM2 transcription factors in prostate cancer
- Disputert:
- februar 2011
- Hovedveileder:
- Karl-Henning Kalland
Gene signatures and prognostic factors in endometrial cancer
- Disputert:
- april 2011
- Hovedveileder:
- Lars A. Akslen
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest