Metabolic homeostasis and obesity. The role of cyclic AMP-dependent signaling.
- Prosjektnummer
- 911406
- Ansvarlig person
- Gunnar Mellgren
- Institusjon
- Universitetet i Bergen
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Metabolic and Endocrine
- Forskningsaktivitet
- 2. Aetiology
The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss.
Int J Obes (Lond) 2012 Sep;36(9):1195-202. Epub 2011 des 6
PMID: 22143616
Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome.
J Biol Chem 2011 Aug;286(32):28382-95. Epub 2011 jun 16
PMID: 21680746
cAMP-mediated regulation of HNF-4alpha depends on the level of coactivator PGC-1alpha.
Biochim Biophys Acta 2010 Sep;1803(9):1013-9. Epub 2010 jun 4
PMID: 20670916
Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells.
Endocrinology 2010 May;151(5):2151-61. Epub 2010 mar 16
PMID: 20233795
Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss.
PLoS One 2010;5(6):e11033. Epub 2010 jun 9
PMID: 20543949
A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation.
Biochim Biophys Acta 2009 Nov;1791(11):1076-83. Epub 2009 jul 3
PMID: 19577662
Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats.
Biochim Biophys Acta 2009 Apr;1791(4):254-62. Epub 2009 jan 31
PMID: 19416649
POSTMan (POST-translational modification analysis), a software application for PTM discovery.
Proteomics 2009 Mar;9(5):1400-6.
PMID: 19253288
Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase.
Endocrinology 2008 Sep;149(9):4336-45. Epub 2008 mai 22
PMID: 18499756
Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes.
Mol Cell Biol 2008 Jun;28(11):3804-16. Epub 2008 apr 7
PMID: 18391018
Cyclic nucleotide analogs as probes of signaling pathways.
Nat Methods 2008 Apr;5(4):277-8.
PMID: 18376388
Low Omental Expression of Fat Loss-Associated Homeobox Transcription Factors in Morbid Obesity.
International Congress of Obesity 2010; 2010-07-11
From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery
Endocrine journal 2010 ;Volum 57. s. S429-S429
Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissue in Morbid Obesity and after Profound Fat Loss
ENDO 2010; 2010-06-19
Bariatric surgery dramatically alters global gene expression in adipose tissue
Norsk Selskap for endokrinologi, Årsmøte, 2009
The role of PKA and CREB in regulation of the steroid receptor coactivator GRIP1/SRC-2
EMBO Conference on nuclear receptors; 2009
Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells.
J Proteomics Bioinform 2, 244-254
Fish Protein Hydrolysate Elevates Plasma Bile Acids and Induces Abdominal Adipose Tissue Expression of Genes Involved in Fatty A
Biochmica et Biophysica Acta, Accepted for publication
cAMP/PKA exerts differential effects on GRIP1- and PGC-1A-mediated HNF-4A transcriptional activity in HepG2 and COS-1 cells
ENDO 2008
cAMP-mediated regulation of HNF-4alpha depends on the level coactivator PGC-1alfa
18th International Symposium of the Journal of Steroid Biochemistry & Molecular Biology, Austria, 2008
Adipose tissue transcriptomics. Integrative search for obesity candidate genes
- Disputert:
- juni 2011
- Hovedveileder:
- Gunnar Mellgren
Cotranslational Phosphorylation - Mechansism and Role in cAMP signaling
- Disputert:
- april 2009
- Hovedveileder:
- Stein Ove Døskeland
Regulation of nuclear receptor coactivator GRIP1 by cAMP-dependent signaling
- Disputert:
- oktober 2008
- Hovedveileder:
- Gunnar Mellgren
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest