Novel approaches in the treatment of AML: Nanoparticles as a delivery tool for both promising drug candidates and conventional drugs
- Prosjektnummer
- 911463
- Ansvarlig person
- Lars Herfindal
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskerutdanning - postdoc
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia.
Eur J Pharm Biopharm 2014 Sep;88(1):186-93. Epub 2014 apr 18
PMID: 24747809
New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities.
Bioorg Chem 2014 Dec;57():108-15. Epub 2014 sep 26
PMID: 25305721
Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.
Mar Drugs 2014 Apr;12(4):2036-53. Epub 2014 apr 3
PMID: 24705501
Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds.
J Enzyme Inhib Med Chem 2014 Apr 3. Epub 2014 apr 3
PMID: 24697298
4-Methylproline guided natural product discovery: co-occurrence of 4-hydroxy- and 4-methylprolines in nostoweipeptins and nostopeptolides.
ACS Chem Biol 2014 Nov 21;9(11):2646-55. Epub 2014 sep 25
PMID: 25203327
Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression.
Biochem Biophys Res Commun 2014 Jul 4;449(3):357-63. Epub 2014 mai 17
PMID: 24845383
Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.
PLoS One 2014;9(4):e94926. Epub 2014 apr 16
PMID: 24740327
Anti-microbial and cytotoxic 1,6-dihydroxyphenazine-5,10-dioxide (iodinin) produced by Streptosporangium sp. DSM 45942 isolated from the fjord sediment.
Appl Microbiol Biotechnol 2014 Jan;98(2):603-10. Epub 2013 okt 26
PMID: 24158735
Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets.
Biochem Biophys Res Commun 2013 Aug 9;437(4):603-8. Epub 2013 jul 12
PMID: 23850619
Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen.
BMC Cancer 2013;13():341. Epub 2013 jul 11
PMID: 23841896
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.
Cell Death Dis 2013;4():e516. Epub 2013 feb 28
PMID: 23449452
Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from Streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells.
Mar Drugs 2013;11(2):332-49. Epub 2013 jan 30
PMID: 23364682
The lipopeptide toxins anabaenolysin A and B target biological membranes in a cholesterol-dependent manner.
Biochim Biophys Acta 2012 Dec;1818(12):3000-9. Epub 2012 jul 25
PMID: 22842546
Anabaenolysins, novel cytolytic lipopeptides from benthic Anabaena cyanobacteria.
PLoS One 2012;7(7):e41222. Epub 2012 jul 19
PMID: 22829929
Nostocyclopeptide-M1: a potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1.
Mol Pharm 2011 Apr;8(2):360-7. Epub 2011 jan 24
PMID: 21214185
The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity.
J Ind Microbiol Biotechnol 2011 Apr;38(4):489-501. Epub 2010 aug 6
PMID: 20689978
Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes.
Mar Drugs 2010;8(10):2659-72. Epub 2010 okt 14
PMID: 21116413
A novel cyanobacterial nostocyclopeptide is a potent antitoxin against microcystins.
Chembiochem 2010 Jul;11(11):1594-9.
PMID: 20575133
Adenosine content and growth in the diatom Phaeodactylum tricornutum (Bacillariophyceae): effect of salinity...
Diatom Research, 2014
Nanokolloidar som verkty for å betra distribusjon av legemiddel
Naturen, 2012, vol 3, s. 103-110
Development and in vitro efficacy of liposomes carrying anthracyclines and emetine for enhanced therapeutic effect
27th GTRV scientific meeting, Paris, 3-5. Dec. 2012
Bioactive compounds from culturable marine microorganisms
Bioprosp 2011, Tromsø
Liver specific transporters of microcystins as a tool to find novel inhibitors of OATP1B1 and OATP1B3
35th FEBS Congress: Molecules of Life; 2010-06-26 - 2010-07-01
- Andrea Trentani Prosjektdeltaker
- Lene Elisabeth Myhren Prosjektdeltaker
- Stein Ove Døskeland Leder av forskningsgruppe
- Nina Lied Larsen Prosjektdeltaker
- Lars Herfindal Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest