Identifying new therapeutic compounds against cancer using in vitro and in vivo screening models - basic mechanisms and developments towards the clinic
- Prosjektnummer
- 911500
- Ansvarlig person
- Anne Margrete Øyan
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer.
Br J Cancer 2011 Mar;104(6):921-6. Epub 2011 feb 22
PMID: 21343929
Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer.
PLoS One 2011;6(1):e14632. Epub 2011 jan 31
PMID: 21297939
Gene expression patterns related to vascular invasion and aggressive features in endometrial cancer.
Am J Pathol 2011 Feb;178(2):861-71.
PMID: 21281818
Reprogramming of cell junction modules during stepwise epithelial to mesenchymal transition and accumulation of malignant features in vitro in a prostate cell model.
Exp Cell Res 2011 Jan;317(2):234-47. Epub 2010 okt 20
PMID: 20969863
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Eur J Haematol 2010 Mar;84(3):239-51. Epub 2009 nov 17
PMID: 19922462
Stathmin is superior to AKT and phospho-AKT staining for the detection of phosphoinositide 3-kinase activation and aggressive endometrial cancer.
Histopathology 2010 Oct;57(4):641-6.
PMID: 20955391
Global profiling of histone and DNA methylation reveals epigenetic-based regulation of gene expression during epithelial to mesenchymal transition in prostate cells.
BMC Genomics 2010;11():669. Epub 2010 nov 25
PMID: 21108828
TMPRSS2:ERG fusion transcripts in urine from prostate cancer patients correlate with a less favorable prognosis.
APMIS 2009 Aug;117(8):575-82.
PMID: 19664128
Hyperoxic treatment induces mesenchymal-to-epithelial transition in a rat adenocarcinoma model.
PLoS One 2009;4(7):e6381. Epub 2009 jul 28
PMID: 19636430
Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype.
Neuropathol Appl Neurobiol 2009 Aug;35(4):380-93.
PMID: 19508445
Tumour virology--history, status and future challenges.
APMIS 2009 May;117(5-6):382-99.
PMID: 19400863
Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia.
BMC Cancer 2009;9():77. Epub 2009 mar 5
PMID: 19265549
Genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis.
PLoS One 2009;4(3):e4687. Epub 2009 mar 5
PMID: 19262738
Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation.
Proc Natl Acad Sci U S A 2009 Mar;106(12):4834-9. Epub 2009 mar 4
PMID: 19261849
Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators.
Br J Haematol 2009 Jan;144(1):53-68. Epub 2008 okt 30
PMID: 19016730
Loss of GPR30 expression identifies estrogen receptor positive endometrial carcinoma patients with poor outcome.
Proceedings of American Association for Cancer 52: 4169, 2011
Gene expression signature characterized by PI3Kinase activation and Stathmin overexpression validates to identify aggressive dis
Proceedings of American Association for Cancer 52: 330, 2011
A tumor-stroma interaction study in red mammary tumors in green mice with and without enhanced oxygenation.
Proceedings of American Association for Cancer 52: 528, 2011
The role of p63 regulation during epithelial to mesenchymal transition (EMT) and subsequent accumulation of malignant features o
Proceedings of American Association for Cancer 52: 3089, 2011
The transcription factor p63 – regulatory mechanisms and potential counteraction of prostate carcinogenesis.
11th Bergen Conference on Cancer Research, Loen 10-11 May, 2010
Gene expression, phenotypic and karyotypic analyses of stepwise prostate carcinogenesis in vitro
AACR 101th Annual Meeting, Washington, USA, April 17 – 21, 2010
Genome-wide profiling of histone and DNA methylation in prostate cells during EMT and malignant transformation.
AACR 101th Annual Meeting, Washington, USA, April 17 – 21, 2010
Genome-wide profiling of histone H3 lysine4 and lysine27 trimethylation reveals an epigenetic signature in prostate carcinogenes
Proceedings of American Association for Cancer Research 50 (511): 121, 2009
Epithelial to mesenchymal transition of a primary prostate cell line before malignant transformation with switches of cell adhes
Proceedings of American Association for Cancer Research 50 (223): 55, 2009
Suppression of heat shock Protein 27 induces long-term dormancy in human breast cancer.
Proceedings of American Association for Cancer Research 50 (159): 39, 2009
Highly infiltrative brain tumors show reduced chemosensitivity associated with a stem cell-like phenotype.
Proceedings of American Association for Cancer Research 50 (182): 45, 2009
Hyperoxic Treatment induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model.
Tumor Microenvironment: Progression, Therapy and Prevention, Versilles, France, 2009
A novel model of stepwise prostate carcinogenesis in culture
Stem Cell Conference, Singapore, 2009
Genome-wide profiling of H3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis
Stem Cell Conference, Singapore, 2009
Global profilingof histone and DNA methylation reveals epigenetic-based gene regulation during EMT and transformation in a prost
Abcam, Chromatin Meeting; Costa Rica, 2009
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest