The Axl receptor is an essential regulator of breast cancer metastasis and patient survival: Diagnostic and therapeutic development
- Prosjektnummer
- 911559
- Ansvarlig person
- James Lorens
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer.
Cancer Res 2013 Feb 15;73(4):1276-86. Epub 2012 des 10
PMID: 23233739
Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation.
ChemMedChem 2012 Dec;7(12):2134-43. Epub 2012 okt 19
PMID: 23086693
Soluble mediators released by acute myeloid leukemia cells increase capillary-like networks.
Eur J Haematol 2012 Dec;89(6):478-90. Epub 2012 okt 26
PMID: 23046151
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation.
Bioorg Med Chem Lett 2012 Sep;22(17):5579-83. Epub 2012 jul 13
PMID: 22853993
Osteogenic stimulatory conditions enhance growth and maturation of endothelial cell microvascular networks in culture with mesenchymal stem cells.
J Tissue Eng 2012;3(1):2041731412443236. Epub 2012 apr 4
PMID: 22511994
Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines.
Cell Biol Toxicol 2012 Aug;28(4):201-12. Epub 2012 mar 16
PMID: 22422053
Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.
Leukemia 2012 May;26(5):910-7. Epub 2011 nov 8
PMID: 22064349
S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest.
Oral Oncol 2012 Mar;48(3):219-25. Epub 2011 okt 26
PMID: 22032898
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer.
Oncogene 2011 Mar;30(12):1436-48. Epub 2010 nov 8
PMID: 21057535
Efficient in vivo vascularization of tissue-engineering scaffolds.
J Tissue Eng Regen Med 2011 Apr;5(4):e52-62. Epub 2010 sep 23
PMID: 20865694
A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients.
Neuropathol Appl Neurobiol 2011 Feb;37(2):189-205.
PMID: 20819169
Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.
Bioorg Med Chem Lett 2011 Feb;21(4):1167-70. Epub 2010 des 24
PMID: 21273066
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.
Proc Natl Acad Sci U S A 2010 Jan;107(3):1124-9. Epub 2009 des 28
PMID: 20080645
Jakter gener i kappløpet mot kreften
Bergens Tidende 10.02.11
Breaking the code for AXL in metastasis
SciBX (Nature) 3: 4-5 (2010)
Using Nanotechnology in Cancer Research
Research Council of Norway, 29/01/2010; Forskning.no, 02/02/2010; Naturfag.no, 01/09/2010
Studies on the role of the Axl receptor tyrosine kinase in breast cancer
- Disputert:
- juni 2011
- Hovedveileder:
- James Lorens
Improved Retroviral Systems for Gene Function Analysis
- Disputert:
- august 2011
- Hovedveileder:
- James Lorens
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest