Pharmacological targeting of leukemic stem cells in human acute myelogenous leukemia
- Prosjektnummer
- 911561
- Ansvarlig person
- Øystein Bruserud
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Blood
- Forskningsaktivitet
- 5. Treatment Developement
Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia.
Blood 2013 Feb 14;121(7):e34-42. Epub 2012 des 12
PMID: 23243270
Inhibition of Mammalian target of rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress.
Bone Marrow Res 2012;2012():329061. Epub 2012 okt 2
PMID: 23082251
High-dose etoposide in allogeneic stem cell transplantation.
Cancer Chemother Pharmacol 2012 Dec;70(6):765-82. Epub 2012 okt 6
PMID: 23053272
Soluble mediators released by acute myeloid leukemia cells increase capillary-like networks.
Eur J Haematol 2012 Dec;89(6):478-90. Epub 2012 okt 26
PMID: 23046151
The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling.
Blood 2012 Jul;120(4):847-57. Epub 2012 jun 12
PMID: 22692509
Targeting of polo-like kinases and their cross talk with Aurora kinases--possible therapeutic strategies in human acute myeloid leukemia?
Expert Opin Investig Drugs 2012 May;21(5):587-603. Epub 2012 mar 17
PMID: 22424119
Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment.
Am J Hematol 2012 Apr;87(4):368-76. Epub 2012 feb 28
PMID: 22374841
Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention.
Br J Haematol 2012 Feb;156(4):468-80. Epub 2011 des 13
PMID: 22150087
Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia.
Leukemia 2012 May;26(5):910-7. Epub 2011 nov 8
PMID: 22064349
The pretransplantation serum cytokine profile in allogeneic stem cell recipients differs from healthy individuals, and various profiles are associated with different risks of posttransplantation complications.
Biol Blood Marrow Transplant 2012 Feb;18(2):190-9. Epub 2011 okt 20
PMID: 22019725
The surface molecule signature of primary human acute myeloid leukemia (AML) cells is highly associated with NPM1 mutation status.
Leukemia 2012 Mar;26(3):557-9. Epub 2011 sep 9
PMID: 21904378
Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia.
Oncogene 2012 Mar;31(12):1533-45. Epub 2011 aug 22
PMID: 21860418
Immunogenic apoptosis in human acute myeloid leukemia (AML): primary human AML cells expose calreticulin and release heat shock protein (HSP) 70 and HSP90 during apoptosis.
Oncol Rep 2011 Jun;25(6):1549-56. Epub 2011 mar 22
PMID: 21431284
Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies.
Bone Marrow Res 2011;2011():570796. Epub 2010 okt 4
PMID: 22046566
Future perspectives: should Th17 cells be considered as a possible therapeutic target in acute myeloid leukemia patients receiving allogeneic stem cell transplantation?
Cancer Immunol Immunother 2011 Dec;60(12):1669-81. Epub 2011 okt 12
PMID: 21989580
The chemokine system in allogeneic stem-cell transplantation: a possible therapeutic target?
Expert Rev Hematol 2011 Oct;4(5):563-76.
PMID: 21939423
Heat shock protein 90 (HSP90) inhibition in acute myeloid leukemia--targeting of disease heterogeneity through direct and indirect antileukemic effects.
Leuk Res 2011 Sep;35(9):1156-8. Epub 2011 jul 30
PMID: 21802728
Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.
J Biomed Biotechnol 2011;2011():104631. Epub 2011 mai 3
PMID: 21629739
Is there a scientific basis for a recommended standardization of collection and cryopreservation of peripheral blood stem cell grafts?
Cytotherapy 2011 Sep;13(8):1013-24. Epub 2011 apr 20
PMID: 21504376
A prospective observational study of the effect of platelet transfusions on levels of platelet-derived cytokines, chemokines and interleukins in acute leukaemia patients with severe chemotherapy-induced cytopenia.
Eur Cytokine Netw 2011 Mar;22(1):52-62.
PMID: 21388914
Current practice and future directions for optimization of platelet transfusions in patients with severe therapy-induced cytopenia.
Blood Rev 2011 May;25(3):113-22. Epub 2011 feb 12
PMID: 21316823
Untangling the intracellular signalling network in cancer--a strategy for data integration in acute myeloid leukaemia.
J Proteomics 2011 Mar;74(3):269-81. Epub 2010 nov 12
PMID: 21075225
The crosstalk between the matrix metalloprotease system and the chemokine network in acute myeloid leukemia.
Curr Med Chem 2010;17(36):4448-61.
PMID: 21062258
The chemokine system in experimental and clinical hematology. Preface.
Curr Top Microbiol Immunol 2010;341():v-vi.
PMID: 20973160
Therapeutic targeting of NF-?B in myelodysplastic syndromes and acute myeloid leukaemia - the biological heterogeneity.
Expert Opin Ther Targets 2010 Nov;14(11):1139-42.
PMID: 20942744
Antivascular combo therapy: up-and-coming.
Blood 2010 Sep;116(9):1389-90.
PMID: 20813902
Hypoxia increases HIF-1a expression and constitutive cytokine release by primary human acute myeloid leukaemia cells.
Eur Cytokine Netw 2010 Sep;21(3):154-64. Epub 2010 aug 20
PMID: 20729179
Heat shock protein 90 (HSP90) inhibition--from experimental to clinical studies.
Leuk Res 2010 Nov;34(11):1422-3. Epub 2010 jul 16
PMID: 20638126
Combination of intensive chemotherapy and anticancer vaccines in the treatment of human malignancies: the hematological experience.
J Biomed Biotechnol 2010;2010():692097. Epub 2010 jun 2
PMID: 20625438
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
BMC Immunol 2010;11():38. Epub 2010 jul 9
PMID: 20618967
Clinical proteomics of myeloid leukemia.
Genome Med 2010;2(6):41. Epub 2010 jun 29
PMID: 20587003
Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia.
Nutr Cancer 2010 Jul;62(5):574-83.
PMID: 20574918
Minor diurnal and activity-induced variations in daytime peripheral blood platelet counts do not have any major impact on platelet yield by platelet apheresis.
Transfus Apher Sci 2010 Aug;43(1):33-6. Epub 2010 jun 16
PMID: 20558109
Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005).
Apoptosis 2010 Aug;15(8):946-55.
PMID: 20467815
The chemokine network in acute myelogenous leukemia: molecular mechanisms involved in leukemogenesis and therapeutic implications.
Curr Top Microbiol Immunol 2010;341():149-72.
PMID: 20376612
The chemokine system in experimental and clinical hematology.
Curr Top Microbiol Immunol 2010;341():3-12.
PMID: 20369318
Early pre-engraftment, functional, in vitro responsiveness of T lymphocytes in allotransplanted, acute leukemia patients: proliferation and release of a broad profile of cytokines, possibly predictive of graft-versus-host disease.
Eur Cytokine Netw 2010 Mar;21(1):40-9.
PMID: 20146989
Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release.
Expert Opin Investig Drugs 2010 Feb;19(2):169-83.
PMID: 20050812
Therapeutic efficacy of platelet transfusion in patients with acute leukemia: an evaluation of methods.
Transfusion 2010 Apr;50(4):766-75. Epub 2009 des 18
PMID: 20030789
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Eur J Haematol 2010 Mar;84(3):239-51. Epub 2009 nov 17
PMID: 19922462
Connexin-based signaling in acute myelogenous leukemia (AML).
Biochim Biophys Acta 2010 Jan;1798(1):1-8. Epub 2009 okt 31
PMID: 19883623
THE PROTEIN KINASE C AGONIST PEP005 (INGENOL 3-ANGELATE) IN THE TREATMENT OF HUMAN CANCER: A BALANCE BETWEEN EFFICACY AND TOXICI
Toxins, 2010
New therapeutic targets in human acute myeloid leukemia
- Disputert:
- mars 2012
- Hovedveileder:
- Øystein Bruserud
Phosphoproteomics in disease stratification and herapy design of acute myeloid leukemia
- Disputert:
- november 2012
- Hovedveileder:
- Bjørn Tore Gjertsen
p53 activating therapy in acute myeloid leukemia
- Disputert:
- august 2012
- Hovedveileder:
- Bjørn Tore Gjertsen
Evaluation of platelet quality and clinical effect of platelet transfusion
- Disputert:
- januar 2010
- Hovedveileder:
- Øystein Bruserud, Tor Hervig
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest