Target Metabolite Profiling Tailored to Establish Novel Biomarkers of Common Diseases
- Prosjektnummer
- 911733
- Ansvarlig person
- Per Magne Ueland
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 4. Detection and Diagnosis
Markers of vitamin B6 status and metabolism as predictors of incident cancer: the Hordaland Health Study.
Int J Cancer 2015 Jun 15;136(12):2932-9. Epub 2014 nov 26
PMID: 25404109
Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris.
Arterioscler Thromb Vasc Biol 2015 Feb;35(2):455-62. Epub 2014 des 18
PMID: 25524770
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes.
J Nutr 2015 Jan;145(1):87-95. Epub 2014 nov 19
PMID: 25527663
Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread.
Br J Nutr 2015 Feb 14;113(3):445-53. Epub 2015 jan 13
PMID: 25585164
Plasma dimethylglycine, nicotine exposure and risk of low bone mineral density and hip fracture: the Hordaland Health Study.
Osteoporos Int 2015 May;26(5):1573-83. Epub 2015 jan 24
PMID: 25616506
A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk.
J Natl Cancer Inst 2015 Apr;107(4). Epub 2015 feb 23
PMID: 25713165
Glycated hemoglobin and long-term prognosis in patients with suspected stable angina pectoris without diabetes mellitus: a prospective cohort study.
Atherosclerosis 2015 May;240(1):115-20. Epub 2015 feb 28
PMID: 25770690
Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.
J Nutr 2015 Apr;145(4):701-7. Epub 2015 feb 18
PMID: 25833774
Kynurenines as predictors of acute coronary events in the Hordaland Health Study.
Int J Cardiol 2015;189():18-24. Epub 2015 mar 30
PMID: 25885868
Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults.
J Nutr 2015 Jul;145(7):1386-93. Epub 2015 mai 13
PMID: 25972531
Direct and Functional Biomarkers of Vitamin B6 Status.
Annu Rev Nutr 2015;35():33-70. Epub 2015 mai 13
PMID: 25974692
Circulating 25-hydroxyvitamin D3 and survival after diagnosis with kidney cancer.
Cancer Epidemiol Biomarkers Prev 2015 Aug;24(8):1277-81. Epub 2015 mai 28
PMID: 26021552
Circulating B-vitamins and smoking habits are associated with serum polyunsaturated Fatty acids in patients with suspected coronary heart disease: a cross-sectional study.
PLoS One 2015;10(6):e0129049. Epub 2015 jun 3
PMID: 26039046
Increased Tryptophan Catabolism is Associated with Increased Frequency of CD161+Tc17/MAIT Cells, and Lower CD4+ T cell Count in HIV-1 infected Patients on cART after Two Years of Follow-up.
J Acquir Immune Defic Syndr 2015 Jul 11. Epub 2015 jul 11
PMID: 26181815
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
Am J Clin Nutr 2015 Sep;102(3):616-25. Epub 2015 jul 22
PMID: 26201817
Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART.
J Acquir Immune Defic Syndr 2015 Dec 1;70(4):329-37.
PMID: 26258571
Efficacy of fish intake on vitamin D status: a meta-analysis of randomized controlled trials.
Am J Clin Nutr 2015 Oct;102(4):837-47. Epub 2015 sep 9
PMID: 26354531
Biomarkers of Nutrition for Development-Folate Review.
J Nutr 2015 Jul;145(7):1636S-1680S. Epub 2015 jun 3
PMID: 26451605
Increased Tryptophan Catabolism Is Associated With Increased Frequency of CD161+Tc17/MAIT Cells and Lower CD4+ T-Cell Count in HIV-1 Infected Patients on cART After 2 Years of Follow-Up.
J Acquir Immune Defic Syndr 2015 Nov 1;70(3):228-35.
PMID: 26470032
Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease.
Eur J Nutr 2017 Feb;56(1):261-272. Epub 2015 okt 19
PMID: 26482150
Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study.
PLoS One 2015;10(10):e0140677. Epub 2015 okt 27
PMID: 26506437
Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case-control study.
Behav Brain Funct 2015;11(1):36. Epub 2015 nov 5
PMID: 26542774
Cosinor modelling of seasonal variation in 25-hydroxyvitamin D concentrations in cardiovascular patients in Norway.
Eur J Clin Nutr 2016 Apr;70(4):517-22. Epub 2015 nov 25
PMID: 26603883
Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial.
BMC Pediatr 2015;15(1):218. Epub 2015 des 18
PMID: 26678525
Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris.
J Am Heart Assoc 2015;5(1). Epub 2015 des 31
PMID: 26722126
Interactions between plasma concentrations of folate and markers of vitamin B(12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study.
Br J Nutr 2014 Mar 28;111(6):1085-95. Epub 2013 nov 11
PMID: 24229560
Circulating biomarkers of tryptophan and the kynurenine pathway and lung cancer risk.
Cancer Epidemiol Biomarkers Prev 2014 Mar;23(3):461-8. Epub 2013 des 19
PMID: 24357106
Vitamin D status was not associated with 'one-year' progression of coronary artery disease, assessed by coronary angiography in statin-treated patients.
Eur J Prev Cardiol 2014 Jan 30. Epub 2014 jan 30
PMID: 24480878
Folic acid supplementation and interpregnancy interval.
Paediatr Perinat Epidemiol 2014 May;28(3):270-4. Epub 2014 feb 10
PMID: 24506308
One-carbon metabolite levels in mid-pregnancy and risks of conotruncal heart defects.
Birth Defects Res A Clin Mol Teratol 2014 Feb;100(2):107-15. Epub 2014 feb 15
PMID: 24532477
Neonatal genome-wide methylation patterns in relation to birth weight in the Norwegian Mother and Child Cohort.
Am J Epidemiol 2014 Apr 1;179(7):834-42. Epub 2014 feb 20
PMID: 24561991
Plasma choline, smoking, and long-term prognosis in patients with stable angina pectoris.
Eur J Prev Cardiol 2014 Mar 4. Epub 2014 mar 4
PMID: 24595862
Most blood biomarkers related to vitamin status, one-carbon metabolism, and the kynurenine pathway show adequate preanalytical stability and within-person reproducibility to allow assessment of exposure or nutritional status in healthy women and cardiovascular patients.
J Nutr 2014 May;144(5):784-90. Epub 2014 mar 19
PMID: 24647388
Smoking and body fat mass in relation to bone mineral density and hip fracture: the Hordaland Health Study.
PLoS One 2014;9(3):e92882. Epub 2014 mar 25
PMID: 24667849
Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease.
Eur J Prev Cardiol 2015 Jun;22(6):743-52. Epub 2014 mar 26
PMID: 24671904
Maternal smoking and DNA methylation in newborns: in utero effect or epigenetic inheritance?
Cancer Epidemiol Biomarkers Prev 2014 Jun;23(6):1007-17. Epub 2014 apr 16
PMID: 24740201
Evidence for increased catabolism of vitamin B-6 during systemic inflammation.
Am J Clin Nutr 2014 May 7;100(1):250-255. Epub 2014 mai 7
PMID: 24808485
Interferon gamma (IFN-?)-mediated inflammation and the kynurenine pathway in relation to risk of hip fractures: the Hordaland Health Study.
Osteoporos Int 2014 Aug;25(8):2067-75. Epub 2014 mai 10
PMID: 24817202
Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Ann Oncol 2014 Aug;25(8):1609-15. Epub 2014 mai 14
PMID: 24827130
Targeted quantification of C-reactive protein and cystatin c and its variants by immuno-MALDI-MS.
Anal Chem 2014 Jun 17;86(12):5807-14. Epub 2014 mai 28
PMID: 24848523
Interferon-?-induced inflammatory markers and the risk of cancer: the Hordaland Health Study.
Cancer 2014 Nov 1;120(21):3370-7. Epub 2014 jun 19
PMID: 24948355
Low folate levels are associated with reduced risk of colorectal cancer in a population with low folate status.
Cancer Epidemiol Biomarkers Prev 2014 Oct;23(10):2136-44. Epub 2014 jul 25
PMID: 25063522
Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-?-mediated immune activation in the community-based Hordaland Health Study.
Br J Nutr 2014 Oct 14;112(7):1065-72. Epub 2014 aug 8
PMID: 25105221
Circulating 25-hydroxyvitamin D3 in relation to renal cell carcinoma incidence and survival in the EPIC cohort.
Am J Epidemiol 2014 Oct 15;180(8):810-20. Epub 2014 sep 8
PMID: 25205830
Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.
Am J Clin Nutr 2014 Oct;100(4):1069-74. Epub 2014 aug 13
PMID: 25240073
Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine.
Genes Nutr 2014 Nov;9(6):435. Epub 2014 okt 17
PMID: 25322900
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival.
J Natl Cancer Inst 2014 Dec;106(12). Epub 2014 nov 5
PMID: 25376861
Plasma choline, nicotine exposure, and risk of low bone mineral density and hip fracture: the Hordaland health study.
J Bone Miner Res 2014 Jan;29(1):242-50.
PMID: 23794246
Sarcosine and other metabolites along the choline oxidation pathway in relation to prostate cancer--a large nested case-control study within the JANUS cohort in Norway.
Int J Cancer 2014 Jan 1;134(1):197-206. Epub 2013 jul 27
PMID: 23797698
Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements.
Mol Nutr Food Res 2013 Apr;57(4):645-52. Epub 2012 sep 24
PMID: 23001761
Use of folic acid supplements in early pregnancy in relation to maternal plasma levels in week 18 of pregnancy.
Mol Nutr Food Res 2013 Apr;57(4):653-60. Epub 2012 okt 15
PMID: 23065724
Dietary intake and biological measurement of folate: a qualitative review of validation studies.
Mol Nutr Food Res 2013 Apr;57(4):562-81. Epub 2012 okt 15
PMID: 23065735
Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas.
Mol Nutr Food Res 2013 Apr;57(4):698-708. Epub 2012 nov 7
PMID: 23132835
Evaluating iron status and the risk of anemia in young infants using erythrocyte parameters.
Pediatr Res 2013 Feb;73(2):214-20. Epub 2012 nov 20
PMID: 23168578
Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E e4: the Hordaland Homocysteine Study.
Psychosom Med 2013 Jan;75(1):20-9. Epub 2012 des 4
PMID: 23213264
North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
Br J Nutr 2013 Jul;110(2):363-74. Epub 2012 des 11
PMID: 23228223
High-throughput, low-volume, multianalyte quantification of plasma metabolites related to one-carbon metabolism using HPLC-MS/MS.
Anal Bioanal Chem 2013 Feb;405(6):2009-17. Epub 2012 des 13
PMID: 23232958
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Am J Clin Nutr 2013 Feb;97(2):310-7. Epub 2013 jan 2
PMID: 23283502
Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study.
Br J Nutr 2013 Jul 28;110(2):330-6. Epub 2013 jan 9
PMID: 23298754
Neopterin and kynurenine-tryptophan ratio as predictors of coronary events in older adults, the Hordaland Health Study.
Int J Cardiol 2013 Sep 30;168(2):1435-40. Epub 2013 jan 18
PMID: 23336953
Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals.
Lancet 2013 Mar 23;381(9871):1029-36.
PMID: 23352552
Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight.
Pediatr Res 2013 Jun;73(6):783-7. Epub 2013 mar 15
PMID: 23503477
Serum folate and vitamin B12 concentrations in relation to prostate cancer risk--a Norwegian population-based nested case-control study of 3000 cases and 3000 controls within the JANUS cohort.
Int J Epidemiol 2013 Feb;42(1):201-10.
PMID: 23508410
A structural equation modelling approach to explore the role of B vitamins and immune markers in lung cancer risk.
Eur J Epidemiol 2013 Aug;28(8):677-88. Epub 2013 mar 27
PMID: 23532743
Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation.
Nutr Rev 2013 Apr;71(4):239-44. Epub 2013 mar 8
PMID: 23550784
Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine.
Am J Clin Nutr 2013 Jun;97(6):1252-9. Epub 2013 apr 17
PMID: 23595875
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Clin Exp Immunol 2013 Jul;173(1):121-30.
PMID: 23607723
Plasma dimethylglycine and risk of incident acute myocardial infarction in patients with stable angina pectoris.
Arterioscler Thromb Vasc Biol 2013 Aug;33(8):2041-8. Epub 2013 mai 30
PMID: 23723367
The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine.
PLoS One 2013;8(5):e64774. Epub 2013 mai 29
PMID: 23734218
Biochemical signs of impaired cobalamin function do not affect hematological parameters in young infants: results from a double-blind randomized controlled trial.
Pediatr Res 2013 Sep;74(3):327-32. Epub 2013 jun 14
PMID: 23770919
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
Am J Clin Nutr 2013 Sep;98(3):668-76. Epub 2013 jul 3
PMID: 23824729
Quantifying the dose-response relationship between circulating folate concentrations and colorectal cancer in cohort studies: a meta-analysis based on a flexible meta-regression model.
Am J Epidemiol 2013 Oct 1;178(7):1028-37. Epub 2013 jul 17
PMID: 23863758
DNA methylation as a long-term biomarker of exposure to tobacco smoke.
Epidemiology 2013 Sep;24(5):712-6.
PMID: 23867811
Urinary excretion of kynurenine and tryptophan, cardiovascular events, and mortality after elective coronary angiography.
Eur Heart J 2013 Sep;34(34):2689-96. Epub 2013 jul 25
PMID: 23886918
Preeclampsia in healthy women and endothelial dysfunction 10 years later.
Am J Obstet Gynecol 2013 Dec;209(6):569.e1-569.e10. Epub 2013 jul 27
PMID: 23899451
Effect of folic acid supplementation on levels of circulating Monocyte Chemoattractant Protein-1 and the presence of intravascular ultrasound derived virtual histology thin-cap fibroatheromas in patients with stable angina pectoris.
PLoS One 2013;8(7):e70101. Epub 2013 jul 25
PMID: 23936148
Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients.
PLoS One 2013;8(8):e69454. Epub 2013 aug 6
PMID: 23936331
Intraindividual variation in one-carbon metabolism plasma biomarkers.
Cancer Epidemiol Biomarkers Prev 2013 Oct;22(10):1894-9. Epub 2013 aug 15
PMID: 23950212
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
J Nutr 2013 Nov;143(11):1719-27. Epub 2013 aug 21
PMID: 23966327
Substrate product ratios of enzymes in the kynurenine pathway measured in plasma as indicators of functional vitamin B-6 status.
Am J Clin Nutr 2013 Oct;98(4):934-40. Epub 2013 sep 4
PMID: 24004893
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Am J Clin Nutr 2013 Nov;98(5):1233-40. Epub 2013 sep 11
PMID: 24025626
Serial plasma choline measurements after cardiac arrest in patients undergoing mild therapeutic hypothermia: a prospective observational pilot trial.
PLoS One 2013;8(9):e76720. Epub 2013 sep 30
PMID: 24098804
Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two Caucasian populations.
Prostaglandins Leukot Essent Fatty Acids 2013 Oct;89(5):297-303. Epub 2013 sep 18
PMID: 24120123
Plasma cotinine levels and pancreatic cancer in the EPIC cohort study.
Int J Cancer 2012 Aug;131(4):997-1002. Epub 2011 nov 2
PMID: 21953524
Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women.
Br J Nutr 2012 Oct;108(7):1264-71. Epub 2011 des 15
PMID: 22172554
Kinetic modeling of storage effects on biomarkers related to B vitamin status and one-carbon metabolism.
Clin Chem 2012 Feb;58(2):402-10. Epub 2011 des 22
PMID: 22194632
Self-reported smoking status and plasma cotinine concentrations among pregnant women in the Norwegian Mother and Child Cohort Study.
Pediatr Res 2012 Jul;72(1):101-7. Epub 2012 mar 22
PMID: 22441375
Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris.
Am J Clin Nutr 2012 May;95(5):1072-8. Epub 2012 apr 4
PMID: 22492365
Increased yet iron-restricted erythropoiesis in postpartum mothers.
Ann Hematol 2012 Sep;91(9):1435-41. Epub 2012 apr 18
PMID: 22526367
Maternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia.
Obstet Gynecol 2012 Jun;119(6):1243-50.
PMID: 22617590
Homocysteine and cardiovascular risk: the perils of reductionism in a complex system.
Clin Chem 2012 Dec;58(12):1623-5. Epub 2012 mai 23
PMID: 22623744
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study.
Br J Nutr 2012 May. Epub 2012 mai 1
PMID: 22717142
Vitamin B6 status and interferon-?-mediated immune activation in primary hyperparathyroidism.
J Intern Med 2012 Dec;272(6):583-91. Epub 2012 aug 5
PMID: 22757621
450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy.
Environ Health Perspect 2012 Oct;120(10):1425-31. Epub 2012 jul 25
PMID: 22851337
Metabolic profiling in Maturity-onset diabetes of the young (MODY) and young onset type 2 diabetes fails to detect robust urinary biomarkers.
PLoS One 2012;7(7):e40962. Epub 2012 jul 30
PMID: 22859960
Relative importance of risk factors for coronary heart disease - The Hordaland Homocysteine Study.
Scand Cardiovasc J 2012 Dec;46(6):316-23. Epub 2012 sep 10
PMID: 22881391
B-vitamin and iron status during infancy
- Disputert:
- januar 2015
- Hovedveileder:
- Anne Lise Bjørke Monsen
Determinants of circulating kynurenines and related markers of inflammation.
- Disputert:
- februar 2015
- Hovedveileder:
- Simone Eussen
Determination of folate species and degradation products in fresh and stored samples by liquid chromatography-tandem mass spectr
- Disputert:
- februar 2012
- Hovedveileder:
- Per Magne Ueland
- Per Magne Ueland Prosjektleder
- Anne Lise Bjørke Monsen Prosjektdeltaker
- Grethe Seppola Tell Prosjektdeltaker
- Stein Emil Vollset Prosjektdeltaker
- Ottar Nygård Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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