Translational Optical Imaging Unit
- Prosjektnummer
- 911789
- Ansvarlig person
- Emmet Martin Mc Cormack
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Other
- Forskningsaktivitet
- 4. Detection and Diagnosis
The project was for the purchase of a preclinical optical imaging system. While the specific projects using the system have user involvement in their design and execution, the funding of the system has not.
JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.
Blood 2017 08 10;130(6):789-802. Epub 2017 jun 15
PMID: 28619982
Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma.
J Control Release 2017 01 10;245():70-80. Epub 2016 nov 18
PMID: 27871988
Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia.
Cell Death Dis 2016 Dec 01;7(12):e2497. Epub 2016 des 1
PMID: 27906185
A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer.
J Control Release 2016 Dec 10;243():172-181. Epub 2016 okt 12
PMID: 27744037
Proceedings from the 1st Insights in Hematology Symposium, Cluj-Napoca, Romania March 11-12, 2016.
Rom J Intern Med 2016 Sep 01;54(3):157-160.
PMID: 27658163
The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer.
PLoS One 2016;11(6):e0158208. Epub 2016 jun 28
PMID: 27352023
Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes.
Biomaterials 2016 Jul;95():11-21. Epub 2016 apr 6
PMID: 27108402
Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying ?-secretase Inhibitors.
Mol Ther 2016 May;24(5):926-36. Epub 2016 feb 26
PMID: 26916284
Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia.
Oncotarget 2016 Feb 16;7(7):8105-18.
PMID: 26812881
Xenograft Models of Primary Acute Myeloid Leukemia for the Development of Imaging Strategies and Evaluation of Novel Targeted Therapies.
Curr Pharm Biotechnol 2016;17(1):42-51.
PMID: 26278528
Establishment of a bioluminescence model for microenvironmentally induced oral carcinogenesis with implications for screening bioengineered scaffolds.
Head Neck 2016 Apr;38 Suppl 1():E1177-87. Epub 2015 aug 14
PMID: 26275210
Role of Hyperplasia of Gingival Lymphatics in Periodontal Inflammation.
J Dent Res 2017 Apr;96(4):467-476. Epub 2017 jan 12
PMID: 28081372
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
J Clin Invest 2016 Sep 01;126(9):3389-402. Epub 2016 aug 15
PMID: 27525437
Impaired lymphatic function accelerates cancer growth.
Oncotarget 2016 Jul 19;7(29):45789-45802.
PMID: 27329584
Multimodal Imaging of Orthotopic Mouse Model of Endometrial Carcinoma.
PLoS One 2015;10(8):e0135220. Epub 2015 aug 7
PMID: 26252891
Determination of lymph flow in murine oral mucosa using depot clearance of near-infrared-labeled albumin.
J Immunol Methods 2015 Oct;425():97-101. Epub 2015 jul 2
PMID: 26141254
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.
J Exp Med 2015 Jun 29;212(7):991-9. Epub 2015 jun 15
PMID: 26077718
Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging.
PLoS One 2015;10(6):e0131037. Epub 2015 jun 25
PMID: 26110789
A Novel Nanoprobe for Multimodal Imaging Is Effectively Incorporated into Human Melanoma Metastatic Cell Lines.
Int J Mol Sci 2015;16(9):21658-80. Epub 2015 sep 8
PMID: 26370983
Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells.
Oncoscience 2014;1(8):529-39. Epub 2014 aug 6
PMID: 25594060
SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute Myeloid Leukemia stem cells.
Cell Stem Cell 2014 Oct 2;15(4):431-46.
PMID: 25280219
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia.
Mol Cancer 2014;13():116. Epub 2014 mai 21
PMID: 24885082
First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma.
PLoS One 2014;9(3):e89527. Epub 2014 mar 4
PMID: 24594904
Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft.
Mol Imaging Biol 2014 Feb;16(1):53-62.
PMID: 23877869
Efficacy of multi-functional liposomes containing daunorubicin and emetine for treatment of acute myeloid leukaemia.
Eur J Pharm Biopharm 2014 Sep;88(1):186-93. Epub 2014 apr 18
PMID: 24747809
Akt1 activity regulates vessel maturation in a tissue engineering model of angiogenesis.
Tissue Eng Part A 2014 Oct;20(19-20):2590-603. Epub 2014 aug 21
PMID: 24957363
A Physiological Perspective on the Use of Imaging to Assess the In Vivo Delivery of Therapeutics.
Ann Biomed Eng 2013 Sep 10. Epub 2013 sep 10
PMID: 24018607
Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases.
J Control Release 2013 Dec 28;172(3):812-22. Epub 2013 okt 29
PMID: 24161382
Automated tracking of nanoparticle-labeled melanoma cells improves the predictive power of a brain metastasis model.
Cancer Res 2013 Apr 15;73(8):2445-56. Epub 2013 feb 19
PMID: 23423977
Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema.
Arterioscler Thromb Vasc Biol 2013 Feb;33(2):266-74. Epub 2013 jan 3
PMID: 23288156
Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors.
Cancer Immunol Immunother 2013 Apr;62(4):773-85. Epub 2012 des 22
PMID: 23263452
Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia.
Blood 2013 Feb 14;121(7):e34-42. Epub 2012 des 12
PMID: 23243270
Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer.
Cancer Res 2013 Feb 15;73(4):1276-86. Epub 2012 des 10
PMID: 23233739
Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival.
Oncotarget 2013 Sep;4(9):1527-46.
PMID: 24127551
Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling.
Cancer Res 2013 Dec 1;73(23):7090-100. Epub 2013 okt 7
PMID: 24101153
In vivo bioluminescence imaging validation of a human biopsy-derived orthotopic mouse model of glioblastoma multiforme.
Mol Imaging 2013 May;12(3):161-72.
PMID: 23490442
Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.
Cell Death Dis 2013;4():e516. Epub 2013 feb 28
PMID: 23449452
Expression of TP53 isoforms p53ß or p53? enhances chemosensitivity in TP53(null) cell lines.
PLoS One 2013;8(2):e56276. Epub 2013 feb 11
PMID: 23409163
MiR-182 and miR-203 induce mesenchymal to epithelial transition and self-sufficiency of growth signals via repressing SNAI2 in prostate cells.
Int J Cancer 2013 Aug 1;133(3):544-55. Epub 2013 feb 27
PMID: 23354685
Functionalized scaffolds for bone tissue engineering.
IADR, Seoul, 2016 (Oral)
Development of a novel scaffold stimulating stem cells growth, differentiation and bone regeneration
Bergen stem cell consortium, Norway 2015 (Oral)
Luciferase expressing dysplastic oral keratinocytes - new 'screening sensors' for tumourigenesis
2nd CCBIO Symbosium Norway 2014
Fluorescence intensity measurements of nano-capsules in Wnt1-induced breast cancer
Master in Pharmacy thesis, University of Bergen, (2015).
Towards novel chemotherapies against acute myeloid leukaemia
Institut Galien, Univeristy of Paris 11 (sud), Chatenay-Malabry. 2014
In vivo biodistribution of fluorescent nanocolloids intended for drug delivery
Master in pharmacy thesis, University of Bergen, (2012).
A new role of the interstitium and lymphatics in the development of hypertension
Acta Physiologica, vol 215, issue supplement S706, p36, 2015
High salt diet results in a hypertonic skin microenvironment.
Acta Physiologica, vol 215, issue supplement S706, p41, 2015
Salt accumulation due to high salt diet enhances lymph drainage in rat's skin
Conference "Bridging Nordic Imaging", Turku, Finland, August, 2015.
Synthetic studies towards nitroreductase-activated fluorescent probes
World Molecular Imaging Congress Honolulu, Hawaii, 2015
Synthetic studies towards nitroreductaseactivated fluorescent probes
MedViz Conference, Bergen, Norway, 2015
Synthesis of CytoCy5S and its active esters for optical imaging
0th European Molecular Imaging Meeting Tu¨bingen, Germany, 2015
Synthesis of CytoCy5S and its NHS ester for optical imaging
30th Organic Chemistry Winter Meeting Skeikampen, Norway, 2015
Gadolinium-incorporated mesoporous silica nanoparticles for MR imaging: long playing contrast agents.
ISMRM, Toronto, Canada, 2015
Sonoporation: From the lab to human clinical trials
Ultrasonics Symposium (IUS), 2014 IEEE International
Evaluation of the effects of clinical diagnostic ultrasound in combination with ultrasound contrast agents on cell stress
Ultrasonics Symposium (IUS), 2014 IEEE International
REPURPOSING PHENOTHIAZINE CHLORPROMAZINE IN THERAPEUTIC TARGETING OF LEUKEMIC STEM CELLS
HAEMATOLOGICA, 2014
CLONAL EVOLUTION IN PRIMARY RESISTANT AML ASSESSED BY GENETIC AND MOLECULAR PROFILING, SINGLE CELL SIGNALLING PROFILING
HAEMATOLOGICA, 2014
Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia
Chemotherapy, 2014
Novel pre-clinical models of myelodysplastic syndrome (MDS)
Experimental Hematology, 2014
PANOBINOSTAT/CARBOPLATIN DELAY POSTSURGICAL RELAPSE OF OVARIAN CARCINOMA IN AN ORTHOTOPIC MOUSE MODEL
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2014
A Novel Model: Microenvironmentally-induced Carcinogenesis For Screening Bone Regeneration Scaffolds
Annual Meeting of the IADR Continental European Division, 2013
A novel model: Microenvironmentally-induced carcinogenesis for screening bone regeneration scaffolds
Poster Abstract 110, CED-IADR, Florence, Italy, September 2013.
Treatment evaluation in AML xenograft models applying multiplexed mAbs and time-domain optical imaging
Abstract Book, 5th National PhD Conference in Medical Imaging 2013, Rica Ishavshotell Tromsø, 2013
PET/CT evaluation of small molecule inhibitors in Patient derived xenograft models of AML with 18F FLT
Abstract Book, 5th National PhD Conference in Medical Imaging 2013, Rica Ishavshotell Tromsø, 2013
Elacytarabine Is More Effective Preclinically Than Cytarabine In Combination With Daunorubicin In AML
Abstract 3958, ASH, New Orleans, 2013
Single Cell Analysis Of Protein Phosphorylation In Chronic Myeloid Leukemia
Abstract 1492, ASH, New Orleans, 2013
Inhibition Of SIRT1 With Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI Treatment
Abstract 2685 ASH, New Orleans, 2013
Molecular Imaging of a Novel Xenograft Model of Myelodysplastic Syndromes (MDS)
Abstract Book, 5th National PhD Conference in Medical Imaging 2013, Rica Ishavshotell Tromsø, 2013
Valproic acid and Hydroxyurea synergize in AML and reveal CHK1-Short as potential biomarker of combination treatment response
Cancer Pharmacogenomics and Targeted Therapies Conference, Wellcome Trust Conference Centre, Hinxton, Cambridge, UK, 2013
Role of integrin a11 in oral carcinogenesis. In vitro and in vivo studies
- Disputert:
- april 2016
- Hovedveileder:
- Daniela Elena Costea
Bioactive copolymer scaffolds for bone tissue engineering. Efficacy and host response
- Disputert:
- desember 2015
- Hovedveileder:
- Kamal Babikeir Eln Mustafa
Ovarian Cancer: A Clinical Challenge Requiring Basic Answers
- Disputert:
- mai 2014
- Hovedveileder:
- Line Bjørge
- Emmet Martin Mc Cormack Prosjektleder
- Emmet Mc Cormack Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest