Targeting cancer stem cell, drug resistance and malignant traits with Axl receptor inhibitors: A new therapeutic strategy to treat advanced malignancy
- Prosjektnummer
- 911794
- Ansvarlig person
- James Lorens
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
Dette prosjekt har ikke hatt brukermedvirkning pga det er en basalforskningsprosjekt. Oppfølgingen av prosjekt via andre milder inkludere pasient representant.
Microsphere cytometry to interrogate microenvironment-dependent cell signaling.
Integr Biol (Camb) 2017 Feb 20;9(2):123-134.
PMID: 28102399
Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity.
Oncoimmunology 2017;6(2):e1271858. Epub 2017 jan 17
PMID: 28344883
Clear Cell Renal Cell Carcinoma is linked to Epithelial-to-Mesenchymal Transition and to Fibrosis.
Physiol Rep 2017 Jun;5(11).
PMID: 28596300
Association of Warfarin Use With Lower Overall Cancer Incidence Among Patients Older Than 50 Years.
JAMA Intern Med 2017 Dec 01;177(12):1774-1780.
PMID: 29114736
Antiviral Screening of Multiple Compounds against Ebola Virus.
Viruses 2016 Oct 27;8(11). Epub 2016 okt 27
PMID: 27801778
A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics.
Dis Model Mech 2015 Oct 1;8(10):1201-11.
PMID: 26438693
Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis.
Cancer Res 2015 Sep 15;75(18):3699-705. Epub 2015 jul 23
PMID: 26206560
Cellular context-mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis.
Mol Biol Cell 2015 Jul 15;26(14):2698-711. Epub 2015 mai 28
PMID: 26023089
Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function.
Cancer Res 2015 Jun 1;75(11):2349-62. Epub 2015 apr 8
PMID: 25855378
In Vitro Characterization of Valproic Acid, ATRA, and Cytarabine Used for Disease-Stabilization in Human Acute Myeloid Leukemia: Antiproliferative Effects of Drugs on Endothelial and Osteoblastic Cells and Altered Release of Angioregulatory Mediators by Endothelial Cells.
Leuk Res Treatment 2014;2014():143479. Epub 2014 jan 8
PMID: 24527217
Mesenchymal stem cells induce endothelial cell quiescence and promote capillary formation.
Stem Cell Res Ther 2014;5(1):23. Epub 2014 feb 17
PMID: 24533904
Molecular deconstruction, detection, and computational prediction of microenvironment-modulated cellular responses to cancer therapeutics.
Adv Drug Deliv Rev 2014 Apr;69-70():123-31. Epub 2014 feb 26
PMID: 24582543
Age-related dysfunction in mechanotransduction impairs differentiation of human mammary epithelial progenitors.
Cell Rep 2014 Jun 26;7(6):1926-39. Epub 2014 jun 5
PMID: 24910432
Flow cytometry-based functional selection of RNA interference triggers for efficient epi-allelic analysis of therapeutic targets.
BMC Biotechnol 2014;14():57. Epub 2014 jun 21
PMID: 24952598
Akt1 activity regulates vessel maturation in a tissue engineering model of angiogenesis.
Tissue Eng Part A 2014 Oct;20(19-20):2590-603. Epub 2014 aug 21
PMID: 24957363
Contextual compound screening for improved therapeutic discovery.
Chembiochem 2013 Dec 16;14(18):2512-8. Epub 2013 nov 12
PMID: 24222525
Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma.
Blood 2013 Oct 3;122(14):2443-52. Epub 2013 aug 27
PMID: 23982172
Evaluating extracellular matrix influence on adherent cell signaling by cold trypsin phosphorylation-specific flow cytometry.
BMC Cell Biol 2013;14():36. Epub 2013 aug 19
PMID: 23957395
p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model.
PLoS One 2013;8(5):e62547. Epub 2013 mai 1
PMID: 23658742
Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer.
Cancer Res 2013 Feb 15;73(4):1276-86. Epub 2012 des 10
PMID: 23233739
Image-based high-throughput screening for inhibitors of angiogenesis.
Methods Mol Biol 2013;931():139-51.
PMID: 23027002
Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer.
Cancer Res. 2018 Jan 1;78(1):246-255.
Heparin Inhibits Proliferation and Migration of Vascular Cells
British journal of Medicine and Medical Research
Novel anti-human Axl monoclonal antibodies for improved patient biomarker studies
Diagnostoc Pathology, 2016
Adaptive mechanisms of resistance to anti- neoplastic agents
MedChemComm 2016
Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure
Oncoimmunology, 2016
The Immortality Two-Step
Cell Cycle, Dec 2014
Methods for creating and identifying functional RNA interference elements.
US. Patent No 8,735,064 Issued 5/27/14
The Tumor Microenvironment as a Transient Niche: A Modulator of Epigenetic States and Stem Cell Functions
rends in Stem Cell Proliferation and Cancer Research, p463-478
Investigations of the cancer therapeutic and protective effects of warfarin-mediated inhibition of AXL
- Disputert:
- november 2017
- Hovedveileder:
- James Lorens
Mechanisms of AXL mediated cell plasticity and drug resistance
- Disputert:
- september 2017
- Hovedveileder:
- James Lorens
The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor
- Disputert:
- mai 2016
- Hovedveileder:
- James Lorens
The role of Axl signaling in phenotypic plasticity in normal and neoplastic epithelial cells
- Disputert:
- april 2015
- Hovedveileder:
- James Lorens
The Role of the Axl Receptor Tyrosine Kinase in Breast Cancer
- Disputert:
- januar 2014
- Hovedveileder:
- James Lorens
Mural Cell-dependent Contextual Regulation of Endothelial Cell Signaling in Angiogenesis
- Disputert:
- mai 2013
- Hovedveileder:
- James Lorens
- Stefan Hinz Ph.d.-kandidat
- Henriette Christie Ertsås Ph.d.-kandidat
- Stacey Ann D'mello Postdoktor
- Kjersti Davidsen Ph.d.-kandidat
- Gry Sandvik Haaland Ph.d.-kandidat
- Jing Kang Ph.d.-kandidat
- Oddbjørn Straume Prosjektdeltaker
- Lars A. Akslen Leder av forskningsgruppe
- James Lorens Prosjektleder
- Sébastien Bougnaud Postdoktor
- Agnete Engelsen Postdoktor
- Katarzyna Wnup-Lipinska Ph.d.-kandidat
- Katarzyna Wnuk-Lipinska Ph.d.-kandidat
- Crina Elena Tiron Ph.d.-kandidat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest