New strategies for targeting endometrial cancer disease progression by pathway (de)activation
- Prosjektnummer
- 911871
- Ansvarlig person
- Henrica Maria Johanna Werner
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis
brukermedvirkning har blitt aktuelt innenfor 2 prosjekter 1. Momatec2: her har pasienter bidratt med å gjenskrive samtykkeskjemaer. 2. Intromat: her er pasienter aktivt involvert med å definiere behovet, målsettingen samt intervensjon. De skal seinere også teste intervensjonen
Proteomic profiling of endometrioid endometrial cancer reveals differential expression of hormone receptors and MAPK signaling proteins in obese versus non-obese patients.
Oncotarget 2017 Dec 05;8(63):106989-107001. Epub 2017 okt 31
PMID: 29291005
High visceral fat percentage is associated with poor outcome in endometrial cancer.
Oncotarget 2017 Dec 01;8(62):105184-105195. Epub 2017 okt 19
PMID: 29285243
HER2 expression patterns in paired primary and metastatic endometrial cancer lesions.
Br J Cancer 2018 02 06;118(3):378-387. Epub 2017 nov 23
PMID: 29169184
Preoperative imaging markers and PDZ-binding kinase tissue expression predict low-risk disease in endometrial hyperplasias and low grade cancers.
Oncotarget 2017 Sep 15;8(40):68530-68541. Epub 2017 jul 31
PMID: 28978135
Type of vascular invasion in association with progress of endometrial cancer.
APMIS 2017 Dec;125(12):1084-1091. Epub 2017 okt 4
PMID: 28975668
PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer.
Sci Rep 2017 Aug 31;7(1):10240. Epub 2017 aug 31
PMID: 28860563
Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival.
Oncotarget 2017 Feb 07;8(6):9696-9707.
PMID: 28039471
Preoperative quantitative dynamic contrast-enhanced MRI and diffusion-weighted imaging predict aggressive disease in endometrial cancer.
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PMID: 29137496
Expression of glucocorticoid receptor is associated with aggressive primary endometrial cancer and increases from primary to metastatic lesions.
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PMID: 28927900
In vivo MR spectroscopy predicts high tumor grade in endometrial cancer.
Acta Radiol 2018 Apr;59(4):497-505. Epub 2017 sep 19
PMID: 28927296
Late-week surgical treatment of endometrial cancer is associated with worse long-term outcome: Results from a prospective, multicenter study.
PLoS One 2017;12(8):e0182223. Epub 2017 aug 3
PMID: 28771617
Expression of L1CAM in curettage or high L1CAM level in preoperative blood samples predicts lymph node metastases and poor outcome in endometrial cancer patients.
Br J Cancer 2017 Sep 05;117(6):840-847. Epub 2017 jul 27
PMID: 28751757
Harmonisation of biobanking standards in endometrial cancer research.
Br J Cancer 2017 Aug 08;117(4):485-493. Epub 2017 jun 29
PMID: 28664917
Changes in Chromatin Structure in Curettage Specimens Identifies High-Risk Patients in Endometrial Cancer.
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PMID: 27587790
Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer.
Cancer Epidemiol Biomarkers Prev 2016 Nov;25(11):1503-1510. Epub 2016 aug 22
PMID: 27550749
Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer.
Oncotarget 2016 Oct 25;7(43):69844-69856.
PMID: 27634881
Androgen receptor as potential therapeutic target in metastatic endometrial cancer.
Oncotarget 2016 Aug 02;7(31):49289-49298.
PMID: 27384477
The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis.
Nat Genet 2016 Aug;48(8):848-55. Epub 2016 jun 27
PMID: 27348297
Five endometrial cancer risk loci identified through genome-wide association analysis.
Nat Genet 2016 Jun;48(6):667-74. Epub 2016 mai 2
PMID: 27135401
CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer.
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PMID: 26574572
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.
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PMID: 26621817
The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.
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PMID: 26330482
ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma.
Oncotarget 2015 Sep 29;6(29):28440-52.
PMID: 26308378
Integrative Protein-Based Prognostic Model for Early-Stage Endometrioid Endometrial Cancer.
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PMID: 26224872
PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients.
Mol Oncol 2015 Oct;9(8):1694-703. Epub 2015 mai 16
PMID: 26045339
DNA ploidy in curettage specimens identifies high-risk patients and lymph node metastasis in endometrial cancer.
Br J Cancer 2015 May 12;112(10):1656-64. Epub 2015 apr 21
PMID: 25897678
Preoperative tumor size at MRI predicts deep myometrial invasion, lymph node metastases, and patient outcome in endometrial carcinomas.
Int J Gynecol Cancer 2015 Mar;25(3):459-66.
PMID: 25628109
Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk.
Hum Genet 2015 Feb;134(2):231-45. Epub 2014 des 9
PMID: 25487306
Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients.
Oncotarget 2015 Jan 20;6(2):1327-39.
PMID: 25415225
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
Hum Mol Genet 2015 Mar 1;24(5):1478-92. Epub 2014 nov 6
PMID: 25378557
Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions.
Eur J Cancer 2014 Nov;50(17):3003-10. Epub 2014 sep 30
PMID: 25281525
Current status of molecular biomarkers in endometrial cancer.
Curr Oncol Rep 2014 Sep;16(9):403.
PMID: 25064587
A pan-cancer proteomic perspective on The Cancer Genome Atlas.
Nat Commun 2014;5():3887. Epub 2014 mai 29
PMID: 24871328
Switch in FOXA1 status associates with endometrial cancer progression.
PLoS One 2014;9(5):e98069. Epub 2014 mai 21
PMID: 24849812
Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations.
Gynecol Oncol 2014 Sep;134(3):599-606. Epub 2014 jul 1
PMID: 24995579
- gordon mills Prosjektdeltaker
- Hege Fredriksen Berg Ph.d.-kandidat
- Camilla Krakstad Leder av forskningsgruppe
- Henrica Maria Johanna Werner Prosjektleder
- johanna Pijnenborg Prosjektdeltaker
- Ane Cecilie Dæhli Munk Prosjektdeltaker
- Solveig Kristi Tingulstad Prosjektdeltaker
- Ivar Jostein Tjugum Prosjektdeltaker
- Elisabeth Berge Nilsen Prosjektdeltaker
- gordon b mills Prosjektdeltaker
- Jone Trovik Prosjektdeltaker
- Marie Ellström Engh Prosjektdeltaker
- Ingvild Vistad Prosjektdeltaker
- Stian Knappskog Prosjektdeltaker
- Per Eystein Lønning Prosjektdeltaker
- Gordon B. Mills Prosjektdeltaker
- Line Bjørge Prosjektdeltaker
- Helga Birgitte Salvesen Hovedveileder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest